Possible Causes for LEOPARD Syndrome in USA

  • Malignant Neoplasm
    Malabsorption Syndrome
  • Noonan Syndrome
    Turner Syndrome

    some common facial features and mental retardation Other RASopathies, particularly: Costello syndrome Legius syndrome Noonan Syndrome with Multiple Lentigines, as known as LEOPARD […] syndrome, a related disorder caused by mutations in PTPN11 that are catalytically inactivating.[1]

  • Shwachman Syndrome
    Malabsorption Syndrome

    Shwachman–Diamond syndrome (SDS) or Shwachman–Bodian–Diamond syndrome is a rare congenital disorder characterized by exocrine pancreatic insufficiency, bone marrow dysfunction, skeletal abnormalities, and short stature. After cystic fibrosis (CF), it is the second most common cause of exocrine pancreatic…[2]

  • Short Bowel Syndrome
    Malabsorption Syndrome

    Short bowel syndrome is a complication of intestinal resection that leads to severe malabsorption, dehydration and profuse diarrhea. The diagnosis can be made by clinical criteria and patient history that includes bowel surgery. Treatment principles depend on the severity of symptoms but fluid administration,…[3]

  • Zollinger Ellison Syndrome
    Malabsorption Syndrome

    Zollinger–Ellison Syndrome is caused by a gastrin-secreting tumor and characterized by severe peptic ulceration, gastric hypersecretion and elevated serum gastrin. Individuals with Zollinger Ellison syndrome exhibit the following signs and symptoms: Pain in the abdomen is present in about 75% of the cases Diarrhea is…[4]

  • Cronkhite-Canada Syndrome
    Malabsorption Syndrome

    Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by generalized gastrointestinal polyps, alopecia, nail changes and hyperpigmentation. In many cases, the symptoms appear in the following order: Gastrointestinal symptoms Weight loss Weakness Edema Ectodermal changes The ectodermal changes occur…[5]

  • Blind Loop Syndrome
    Malabsorption Syndrome

    Blind loop syndrome is a complication of Billroth II gastrectomy and gastroenterostomy or other end-to-end or end-to-side bowel anastomosis consisting of dilatation of a bypassed intestinal loop, that becomes excluded from normal intestinal transit. This can lead to stasis, bacterial population overgrowth, mucosal…[6]

  • Malignant Carcinoid Syndrome
    Malabsorption Syndrome

    Carcinoids are neuroendocrine tumors most commonly originating from the midgut. Primary tumors and possibly existing metastases produce a variety of hormones and hormone-like mediators that provoke systemic symptoms like flushing, diarrhea and cardiac insufficiency - the entirety of these symptoms is referred to…[7]

  • Klippel-Feil Syndrome
    Turner Syndrome

    Klippel Feil syndrome is a very rare medical disorder that presents with a triad of short webbed neck, limited range of motion of the cervical spine and a low hair line. The disorder may be isolated but it can also present in association with numerous other syndromes. The clinical presentation of patients with…[8]

  • Acquired Immunodeficiency Syndrome
    Malabsorption Syndrome

    Acquired immunodeficiency syndrome (AIDS) is considered to be the most severe stage of human immunodeficiency virus (HIV) infection. It is life-threatening if therapy is not initiated immediately. Patients present with constitutional symptoms of variable severity, wasting, and numerous AIDS-defining illnesses. Clinical…[9]

Further symptoms

Similar symptoms


  1. Wikipedia: Noonan syndrome, CC-BY-SA-3.0
  2. Wikipedia: Shwachman–Diamond syndrome, CC-BY-SA-3.0
  3. Short Bowel Syndrome, Symptoma
  4. Zollinger Ellison Syndrome, Symptoma
  5. Cronkhite-Canada Syndrome, Symptoma
  6. Blind Loop Syndrome, Symptoma
  7. Malignant Carcinoid Syndrome, Symptoma
  8. Klippel-Feil Syndrome, Symptoma
  9. Acquired Immunodeficiency Syndrome, Symptoma