Create issue ticket

243 Possible Causes for Leptin Receptor Deficiency

  • Metabolic Syndrome

    In lipodystrophy, insulin resistance is a direct consequence of leptin deficiency, and thus leptin replacement reverses metabolic syndrome abnormalities, including diabetes[ncbi.nlm.nih.gov] We present 3 cases of extreme syndromic insulin resistance: lipodystrophy, autoantibodies to the insulin receptor, and mutations in the insulin receptor gene, with accompanying[ncbi.nlm.nih.gov] The insulin "receptoropathies," including autoantibodies to the insulin receptor and insulin receptor gene mutations, are characterized by extreme insulin resistance and ovarian[ncbi.nlm.nih.gov]

  • Insulin Resistance

    In lipodystrophy, insulin resistance is a direct consequence of leptin deficiency, and thus leptin replacement reverses metabolic syndrome abnormalities, including diabetes[ncbi.nlm.nih.gov] First, this view is not inconsistent with the fact that severe obesity results from mutations that disable leptin or its receptor.[doi.org] We present 3 cases of extreme syndromic insulin resistance: lipodystrophy, autoantibodies to the insulin receptor, and mutations in the insulin receptor gene, with accompanying[ncbi.nlm.nih.gov]

  • Obesity

    Clinical Phenotypes Associated with Leptin and Leptin Receptor Deficiency The clinical phenotypes associated with congenital leptin and leptin receptor deficiencies are similar[doi.org] Genetically obese, leptin receptor deficient rodents have impaired performance on spatial memory tasks 24 and long term potentiation of neurons in the hippocampus. 25 C reactive[dx.doi.org] A mutation in the leptin receptor gene is responsible for the obese phenotype of dbldb mice.[doi.org]

  • Arthritis

    Both leptin-deficient ob/ob mice and leptin receptor-deficient db/db mice reveal increased adiposity together with decreased BMD, suggesting an association between adiposity[doi.org] Insulin deficiency or resistance as well as hyperglycemia in patients with diabetes are known risk factors for metabolic bone diseases, including osteoporosis [29].[doi.org]

  • Asthma

    […] adipokine imbalance has been associated with increased systemic oxidative stress, and it also occurs in the airways, as shown in a study by Holguin et al. ( 18 ), in which obese leptin-receptor-deficient[oadoi.org] […] mice ( db / db ) had significantly larger concentration of leptin and reduced adiponectin in the BAL fluid, compared with wild-type lean mice.[oadoi.org]

  • Lafora Disease

    Nature, 389, 374 – 377. 17 ( 2014 ) Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr.[doi.org] Nature , 389 , 374 – 377 . 17 ( 2014 ) Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes . Curr.[academic.oup.com] We demonstrate here that mice that were deficient for both laforin and leptin receptor showed a reduction in the glycogen level, Lafora bodies and gliosis in the brain, and[ncbi.nlm.nih.gov]

  • Familial Hypercholesterolemia

    Deficiency 6 Obesity, Morbid, Due to Leptin Receptor Deficiency 6 Obsessive-Compulsive Disorder 1 Occipital Horn Syndrome 2 Occult Macular Dystrophy 2 Ocular Albinism, Type[preventiongenetics.com] […] levels and leptin receptor abnormalities have been reported in childhood cancer survivors. 367,368 Radiation exposure to the hypothalamic-pituitary axis in children can result[doi.org] Myelomonocytic Leukemia 4 Noonan-Like Syndrome With Loose Anagen Hair 4 Norrie Disease 4 Norum Disease 1 Nystagmus 6, Congenital, X-Linked 2 Obesity 3 Obesity, Morbid, Due to Leptin[preventiongenetics.com]

  • Arteriosclerosis

    This in vivo observation is substantiated by experimental findings showing that the number of Treg is increased in leptin-deficient ( ob/ob ) and leptin receptor-deficient[physrev.physiology.org] Yet, leptin deficiency causes marked hypercholesterolemia and lesions of ob / ob LDLr / mice appear to be much smaller than those usually observed in mice of similar age ([physrev.physiology.org]

  • Familial Isolated Dilated Cardiomyopathy

    receptor gene deficiency Rare endocrine disease 1 1 0 Early-onset autosomal dominant Alzheimer disease Rare neurologic disease 2 0 0 Early-onset autosomal dominant Alzheimer[mousebook.org] 0 Muir-Torre syndrome Rare gastroenterologic disease Rare skin disease Rare eye disease Rare oncologic disease Rare gynecologic or obstetric disease 1 0 0 Obesity due to leptin[mousebook.org]

  • Zinc Deficiency

    With the discovery of leptin receptors in reproductive tissues ( Barash et al. 1996 ), a reduction in leptin levels due to zinc deficiency may help explain why certain specific[jn.nutrition.org] Dysregulation of leptin during zinc deficiency has the potential to affect both central and peripheral physiology, in that leptin receptors have been identified within reproductive[jn.nutrition.org] Reductions in leptin during zinc deficiency likely provide the basis for a new hypothesis relating zinc deficiency to reproductive dysfunction.[jn.nutrition.org]

Further symptoms