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Glioblastoma Multiforme
Leptomeningeal metastasis and dissemination were diagnosed with magnetic resonance imaging. … Spinal MRI with gadolinium enhancement is the current investigation of choice for leptomeningeal metastasis. … Because of the diffuse nature of the disease, leptomeningeal metastasis is often unsuitable for surgical decompression.[1]
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Leukemia
Leptomeningeal Metastasis
Leukemia is cancer of the blood forming tissues that also affects the bone marrow and the lymphatic system. Such a type of cancer causes abnormal development of cells that gradually enter the bloodstream.
Symptoms of leukemia vary with the type. The common symptoms of the disease include the following: Undue…[2]
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Acute Leukemia
Leptomeningeal Metastasis
Both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are an acute form of leukemia characterized by proliferation of early lymphoid/myeloid precursor cells which replace the normal hematopoietic cells of the bone marrow.
Patients with ALL and AML may present with symptoms related to either…[3]
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Acute Myelocytic Leukemia
Leptomeningeal Metastasis
Acute myelocytic leukemia is a myeloproliferative disorder characterized by the accumulation of abnormal myeloid precursors in the bone marrow. The disease may be associated with end organ dysfunction resulting from an infiltration with leukemic cells, but mortality is most commonly due to the consequences of bone…[4]
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Acute Monocytic Leukemia
Leptomeningeal Metastasis
You are here Acute monocytic leukemia. These lesions are rarely found in chronic leukemia but are a common finding in acute forms. They appear as erythematous infiltrations of the skin, forming papules, macules, and plaques. Pruritus may be present. Revision Last Reviewed 5/20/2016 by Todd Gersten, MD,…[5]
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Leptomeningeal Metastasis
The spread of malignancies to the central nervous system may either result in a single leptomeningeal metastasis, multiple secondary tumors or parenchymal brain lesions. … Accordingly, patients may develop a single leptomeningeal metastasis (LM) or present with multiple secondary tumors to be encountered in pia mater and arachnoid mater. … Consequently, few patients present with a single leptomeningeal metastasis (LM) - the majority of affected individuals suffer from several metastases that interfere with brain[6]
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Peritoneal Carcinomatosis
Metastatic Cancer ; National Cancer Institute (US) Clarke JL ; Leptomeningeal metastasis from systemic cancer. … Walbert T, Groves MD ; Known and emerging biomarkers of leptomeningeal metastasis and its response to Future Oncol. 2010 Feb 6(2):287-97. … Rudnicka H, Niwinska A, Murawska M ; Breast cancer leptomeningeal metastasis--the role of multimodality treatment.[7]
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Carcinomatosis
Metastatic Cancer ; National Cancer Institute (US) Clarke JL ; Leptomeningeal metastasis from systemic cancer. … Walbert T, Groves MD ; Known and emerging biomarkers of leptomeningeal metastasis and its response to Future Oncol. 2010 Feb 6(2):287-97. … Rudnicka H, Niwinska A, Murawska M ; Breast cancer leptomeningeal metastasis--the role of multimodality treatment.[8]
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Small Cell Carcinoma of the Lung
Chamberlain MC Current concepts in leptomeningeal metastasis. … Chamberlain MCCorey-Bloom J Leptomeningeal metastasis: indium-DTPA CSF flow studies. … Chamberlain MCSandy APress GA Leptomeningeal metastasis: a comparison of gadolinium-enhanced MR and contrast-enhanced CT of the brain.[9]
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Procarbazine
in situ of the cervix maternity or breastfeeding Evidence of active infection within 2 weeks prior to study Previous treatment with procarbazine and/or CCNU Evidence of leptomeningeal … metastasis Unable to comply with the study protocol Choosing to participate in a study is an important personal decision.[10]