86 Possible Causes for Lesch Nyhan Syndrome in USA

  • Gouty Tophus

    hypoxanthine-guanine phosphoribosyl transferase deficiency [HGPRT]) Secondary gout (10%): increased nucleic acid turnover due to leukemia/lymphoma, chronic renal disease, HGPRT deficiency Lesch-Nyhansyndrome: rare; men with HGPRT deficiency causing hyperuricemia, severe neurologic deficits with developmental disabilities, self mutilation, gouty arthritis ( OMIM: Lesch-NyhanSyndrome; LNS ) Arthritis: synovial fluid is poorer solvent for sodium urate than plasma, so with hyperuricemia, urates in joint fluid crystallize, particularly in ankle[1]

  • Olecranon Bursitis

    Ischemic necrosis of femoral / humeral heads Bone infarction Coexisting disorders: Psoriasis Glycogen storage disease Type I Hypo- and hyperparathyroidism Down’s syndrome Lesch-Nyhansyndrome (choreoathetosis, spasticity, mental retardation, self-mutilation of lips fingertips) Treatment Colchicine, allopurinol (effective treatment usually does not change[2]

  • Lesch Nyhan Syndrome

    Lesch Nyhan syndrome (LNS) is a hereditary disorder of purine metabolism which consists in a severe form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency … Lesch Nyhan Syndrome (LNS) is a genetic disorder which is characterized by three major symptoms, as indicted previously: a characteristic overproduction of uric acid, combined … Lesch Nyhan syndrome (LNS) is a genetic disorder which consists in a disruption of the normal mechanism to build and break down purines, one of the components of DNA and RNA[3]

  • Hyperuricemia

    Other cases where allopurinol is indicated include the inherited enzyme deficiency disorders, such as Lesch-Nyhan Syndrome and Kelley-Seegmiller syndromes, as well as the … The overproduction type of hyperuricemia is seen in conditions like Lesch-Nyhan Syndrome, where there is deficiency of the hypoxanthine guanine phosphoribosyl transferase … The Lesch-Nyhan syndrome is also associated with extremely high levels of uric acid.[4] [5]

  • Allopurinol

    Lesch-Nyhan syndrome). … spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including LeschNyhansyndrome; glucose 6-phosphatase including glycogen storage disease; phosphoribosyl pyrophosphate synthetase, phosphoribosyl pyrophosphate amidotransferase; adenine phosphoribosyltransferase[6] [7]

  • Tongue Ulcer

    even be the initial manifestation of neurological diseases such as familial dysautonomia (Riley-Day syndrome), congenital autonomic dysfunction with universal pain loss, or Lesch-Nyhansyndrome. 2–6 Domingues-Cruz et al. 6 proposed a classification based on age at onset and associated diseases.[8]

  • Dementia

    Information Page Lateral Medullary Syndrome Information Page Learning Disabilities Information Page Leigh's Disease Information Page Lennox-Gastaut Syndrome Information Page Lesch-NyhanSyndrome Information Page Leukodystrophy Information Page Levine-Critchley Syndrome Information Page Lewy Body Dementia Information Page Lipid Storage Diseases Information[9]

  • Hereditary Spherocytosis

    Bacteria By Disease / Model By Focus Area By Tissue Cell Lines Human Primary Cells Browse by: Cystic Fibrosis Down Syndrome Ehlers-Danlos Syndrome Hereditary Spherocytosis Lesch-NyhanSyndrome Marfan Syndrome Peritonitis Rhinopharyngitis Trachoma Ulcerative Balanitis Vaginitis Vesicular Stomatitis Cervicitis Conjunctivitis Encephalomyocarditis Gastroenteritis[10]

  • Megaloblastic Anemia

    Combined folate and vitamin B12 deficiency Tropical sprue Gluten-sensitive enteropathy Inherited disorders of DNA synthesis Orotic aciduria; Lesch-Nyhan syndrome; Thiamine … malabsorption Dihydrofolate reductase deficiency N 5 -methyl tetrahydrofolate - Homocysteine methyltransferase deficiency Other inborn errors Hereditary orotic aciduria Lesch-Nyhansyndrome Thiamine-responsive megaloblastic anemia - This condition is an autosomal recessive disorder with features that include megaloblastic anemia, deafness, and diabetes[11] [12]

  • Fluphenazine

    His firm has also tested the drug as a treatment for pathological gambling and for self-injurious behaviors associated with Lesch-Nyhan syndrome.[13]

Similar symptoms

References

  1. Pathology Outlines - Gout and gouty arthritis, http://www.pathologyoutlines.com/topic/jointsgout.html
  2. LearningRadiology - gout, olecranon, bursitis, http://learningradiology.com/notes/bonenotes/bu…
  3. Lesch Nyhan Syndrome, https://www.symptoma.com/en/info/lesch-nyhan-sy…
  4. Hyperuricemia, https://www.symptoma.com/en/info/hyperuricemia
  5. Hyperuricemia, https://en.wikipedia.org/wiki/Hyperuricemia
  6. Allopurinol, https://en.wikipedia.org/wiki/Allopurinol
  7. Buy Puricos (Allopurinol) Online Without Prescription, http://generalhealthmeds.org/puricos/
  8. Tongue Ulcer in a 7-Month-Old Infant, http://www.actasdermo.org/en/tongue-ulcer-in-7-…
  9. All Disorders | National Institute of Neurological Disorders and Stroke, http://www.ninds.nih.gov/disorders/dementias/de…
  10. Hereditary Spherocytosis Page 1, http://www.atcc.org/Products/Cells%20and%20Micr…
  11. Megaloblastic Anemia - Medicine lecture Notes, https://sites.google.com/site/medicinelectureno…
  12. Macrocytic - Megaloblastic Anemia, http://enotes.tripod.com/anemia-macrocytic.htm
  13. AAN: Old Drug Safe in Tourette, New Drug Relieves Tics, http://www.medpagetoday.com/MeetingCoverage/AAN…