Question

    116 Possible Causes for Lesch Nyhan Syndrome in USA

    • Bruxism
      Lesch Nyhan Syndrome
    • Nephrolithiasis
      Lesch Nyhan Syndrome

      Rare congenital disorders of purine metabolism, such as Lesch-Nyhan syndrome, are associated with uric acid stones, hyperuricosuria, and hyperuricemia.[1]

    • Arthralgia
      Lesch Nyhan Syndrome
    • Lesch Nyhan Syndrome

      Lesch-Nyhan Syndrome Registry. … A woman is at risk of being a carrier if she has a son with Lesch-Nyhan syndrome or someone in her family has Lesch-Nyhan syndrome. … Lesch-Nyhan Syndrome Definition Lesch-Nyhan syndrome, which is also known as HPRT deficiency or Kelley-Seegmiller syndrome, is a rare genetic disorder that affects males.[2]

    • Gouty Tophus

      syndrome: rare; men with HGPRT deficiency causing hyperuricemia, severe neurologic deficits with developmental disabilities, self mutilation, gouty arthritis ( OMIM: Lesch-Nyhan … […] hypoxanthine-guanine phosphoribosyl transferase deficiency [HGPRT]) Secondary gout (10%): increased nucleic acid turnover due to leukemia/lymphoma, chronic renal disease, HGPRT deficiency Lesch-NyhanSyndrome; LNS ) Arthritis: synovial fluid is poorer solvent for sodium urate than plasma, so with hyperuricemia, urates in joint fluid crystallize, particularly in ankle[3]

    • Dementia

      Information Page Lateral Medullary Syndrome Information Page Learning Disabilities Information Page Leigh's Disease Information Page Lennox-Gastaut Syndrome Information Page Lesch-NyhanSyndrome Information Page Leukodystrophy Information Page Levine-Critchley Syndrome Information Page Lewy Body Dementia Information Page Lipid Storage Diseases Information[4]

    • Hyperuricemia

      Other cases where allopurinol is indicated include the inherited enzyme deficiency disorders, such as Lesch-Nyhan Syndrome and Kelley-Seegmiller syndromes, as well as the … The overproduction type of hyperuricemia is seen in conditions like Lesch-Nyhan Syndrome, where there is deficiency of the hypoxanthine guanine phosphoribosyl transferase … The Lesch-Nyhan syndrome is also associated with extremely high levels of uric acid.[5] [6]

    • Olecranon Bursitis

      Ischemic necrosis of femoral / humeral heads Bone infarction Coexisting disorders: Psoriasis Glycogen storage disease Type I Hypo- and hyperparathyroidism Down’s syndrome Lesch-Nyhansyndrome (choreoathetosis, spasticity, mental retardation, self-mutilation of lips fingertips) Treatment Colchicine, allopurinol (effective treatment usually does not change[7]

    • Allopurinol

      Lesch-Nyhan syndrome). … […] spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including LeschNyhansyndrome; glucose 6-phosphatase including glycogen storage disease; phosphoribosyl pyrophosphate synthetase, phosphoribosyl pyrophosphate amidotransferase; adenine phosphoribosyltransferase[8] [9]

    • Tongue Ulcer

      […] even be the initial manifestation of neurological diseases such as familial dysautonomia (Riley-Day syndrome), congenital autonomic dysfunction with universal pain loss, or Lesch-Nyhansyndrome. 2–6 Domingues-Cruz et al. 6 proposed a classification based on age at onset and associated diseases.[10]

    Further symptoms

    Similar symptoms

    References

    1. Nephrolithiasis, http://www.clevelandclinicmeded.com/medicalpubs…
    2. Lesch-Nyhan syndrome | definition of Lesch-Nyhan syndrome by Medical dictionary, http://medical-dictionary.thefreedictionary.com…
    3. Pathology Outlines - Gout and gouty arthritis, http://www.pathologyoutlines.com/topic/jointsgout.html
    4. All Disorders | National Institute of Neurological Disorders and Stroke, http://www.ninds.nih.gov/disorders/dementias/de…
    5. Hyperuricemia, https://en.wikipedia.org/wiki/Hyperuricemia
    6. Hyperuricemia, https://www.symptoma.com/en/info/hyperuricemia
    7. LearningRadiology - gout, olecranon, bursitis, http://learningradiology.com/notes/bonenotes/bu…
    8. Buy Puricos (Allopurinol) Online Without Prescription, http://generalhealthmeds.org/puricos/
    9. Allopurinol, https://en.wikipedia.org/wiki/Allopurinol
    10. Tongue Ulcer in a 7-Month-Old Infant, http://www.actasdermo.org/en/tongue-ulcer-in-7-…