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29 Possible Causes for Lethargy, Loss of Axillary Hair, Midline Defects

  • Panhypopituitarism

    Characteristic signs of the disorder are failure to lactate, amenorrhea (in females), weakness, cold intolerance, lethargy, and loss of libido and of axillary and pubic hair[] CONCLUSION: These data demonstrate that homozygous HESX1 mutation causing an R160H substitution can result in panhypopituitarism without midline defects.[] Nonspecific symptoms are most frequently seen in the form of exercise intolerance, abdominal pain, loss of axillary and pubic hair weakness or fatigue, Increase in weight,[]

  • Hypothyroidism

    A 75-year-old man experienced neurologic symptoms including memory impairment, ataxic gait, sensory polyneuropathy and myopathy, lethargy, and edema of the face and lower[] defects of the brain, should alert the physician to suspect the diagnosis of septo-optic dysplasia.[] Physical signs of hypothyroidism include the following: Weight gain Slowed speech and movements Dry skin Jaundice Pallor Coarse, brittle, straw-like hair Loss of scalp hair[]

  • Anterior Pituitary Hypofunction

    Assess for lassitude, lethargy, fatigue, and muscular weakness. C. Check out any gastrointestinal (GI) disturbances, nausea, diarrhea, and anorexia. D.[] It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects.[] […] of pubic and axillary hair Atrophy of breast and Testis What are the steps in evaluating anterior pituitary hypofunction?[]

  • Hypogonadism

    […] associated with decreased insulin sensitivity, central obesity, hyperlipidemia, hypertension, osteoporosis, muscle weakness and decreased strength, cognitive impairment, lethargy[] Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[] Other signs of low testosterone include depressive symptoms, a decrease in cognitive abilities, irritability and lethargy or loss of energy.[]

  • Luteinizing Hormone Deficiency

    […] deepen (larynx underdeveloped) Gynecomastia (breast development) Poor growth (height) surge Adulthood Mood changes (low mood and irritability) Poor concentration Low energy (lethargy[] There was no anosmia, midline defects or gynaecomastia. He had scanty pubic hair which came only after testosterone injection (Tanner stage 2) but no axillary hair.[] Weakness, hypoglycemia, weight loss, and decreased axillary and pubic hair suggest the diagnosis.[]

  • Hypopituitarism

    A 67-year-old Japanese man presented to our hospital with generalized weakness, lethargy, and weight loss.[] , eye anomalies, and midline/ventral defects).[] […] of axillary and pubic hair In women: cessation of menstruation (amenorrhea), breast atrophy, vaginal dryness, absence of milk production in new mothers (Sheehan’s syndrome[]

  • Iatrogenic or Traumatic Pituitary Deficiency

    In view of history of pregnancy and significant blood loss during surgery and long history of lethargy, asthaenia and generalised anasarca, the patient was evaluated for Sheehan's[] Head injury (may have occurred up to several years before). [ 4 ] Congenital: Kallmann's syndrome (congenital hypogonadotropic hypogonadism with midline defects such as anosmia[] […] of libido, infertility, testicular atrophy, loss of facial, axillary and/or pubic hair, gynecomastia TSH deficiency : weight gain, cold intolerance, lethargy, constipation[]

  • Suprasellar Tumor

    The next frequent symptoms were headache and generalized lethargy.[] However, the field defect in tilted-disc syndrome is unchanging and does not respect the vertical midline, whereas the field defects in chiasm-compressive lesions are progressive[] Physical examination revealed axillary and groin hair loss, hypogonadism, orthostatic hypotension, and a possible mild bitemporal visual field deficit.[]

  • Congenital Isolated ACTH Deficiency

    In cases arising from loss of function caused by an expanding silent mass lesion, the onset of symptoms is insidious, typically occurring with mild headaches, lethargy, fatigue[] Neonates who have congenital defects of the pituitary or hypothalamus may have hypoglycemia (which also can occur in older children), midline defects (eg, cleft palate), or[] […] and decreased axillary and pubic hair.[]

  • Hypogonadotropic Hypogonadism Type 22

    […] development decreased testicular size enlarged breasts Symptoms of adult-onset hypogonadism include: erectile dysfunction low sperm count depressed mood decreased libido lethargy[] There was no anosmia or midline defects. A CT scan showed empty sella turcica.[] The proband (Subject III-3 in Figure 1 ) was seen at the age of 16 days because of vomiting, lethargy, dehydration, hyponatremia, and hyperkalemia.[]

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