Possible Causes for Leucine Decreased in USA

  • Huntington's Disease
    Leucine Decreased

    Huntington disease (Huntington's chorea) is an incurable, neurodegenerative, autosomal dominant inherited disorder caused by an elongated CAG repeat on the short arm of chromosome 4p16.3 in the Huntingtine gene. The signs and symptoms of the disease consist of motor, cognitive and psychiatric disturbances. The…[1]

  • Hepatic Encephalopathy
    Leucine Decreased

    Hepatic encephalopathy (HE) is a pathological condition defined by the spectrum of neuropsychiatric abnormalities which result from a liver dysfunction. It is known in the scientific community with a number of different names, such as portosystemic encephalopathy, liver encephalopathy or hepatic coma. HE…[2]

  • Maple Syrup Urine Disease
    Leucine Increased

    The classic MSUD would present the earliest among neonates from first to second week of life. They may present with lethargy, vomiting, irritability, abnormal movements, poor feeding habits and poor weight gain which are eminently the offshoot of the neurological effects of leucine accumulation in the brain and…[3]

  • Obesity
    Leucine Increased

    In the United States, 36% of the population are clinically obese as of 2010. Obesity remains to be a looming major health crisis internationally where its prevalence rate is increasing rapidly especially in the first world countries worldwide. Obesity is technically defined as having a BMI of more than 30. BMI is an index…[4]

  • Multiple Carboxylase Deficiency
    Leucine Increased

    Multiple carboxylase deficiency is a form of metabolic disorder involving failures of carboxylation enzymes. The deficiency can be in biotinidase or holocarboxylase synthetase. These conditions respond to biotin. Forms include: Holocarboxylase synthetase deficiency - neonatal; Biotinidase deficiency - late onset; If…[5]

  • HMG-CoA Lyase Deficiency
    Leucine Increased

    HMG-CoA lyase deficiency is a rare genetic disorder characterized by the deficiency of an enzyme that is necessary for the synthesis of ketone bodies and metabolism of leucine, an essential amino acid. Thus, patients present with severe and potentially life-threatening hypoglycemia, ketotic acidosis, hyperammonemia,…[6]

  • Isovalericacidemia
    Leucine Increased

    Isovalericacidemia (IVA) is a rare metabolic disorder that is classified under the category of organic acidemias and is characterized by an inborn deficiency of the isovaleryl-CoA dehydrogenase (IVD) enzyme, which mediates leucine catabolism. IVA is usually diagnosed in children and manifests with two types - acute and…[7]

  • Viral Hepatitis
    Leucine Increased

    Viral hepatitis is an inflammatory liver condition that most commonly arises from hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). The prevalence of these viruses varies geographically. The clinical picture of acute viral hepatitis is variable…[8]

  • DiGeorge Syndrome
    Calcium Decreased

    DiGeorge syndrome (DGS) belongs to a group of phenotypically similar disorders which share a microdeletion at band 22q11.2. One of the most common reasons to suspect DGS is the presence of a conotruncal cardiac anomaly. Neonatatal hypocalcemia will also bring about suspicion of this syndrome especially in cases…[9]

  • Mandragora Officinarum
    Decreased Sweating

Further symptoms

References

  1. Huntington's Disease, Symptoma
  2. Hepatic Encephalopathy, Symptoma
  3. Maple Syrup Urine Disease, Symptoma
  4. Obesity, Symptoma
  5. Wikipedia: Multiple carboxylase deficiency, CC-BY-SA-3.0
  6. HMG-CoA Lyase Deficiency, Symptoma
  7. Isovalericacidemia, Symptoma
  8. Viral Hepatitis, Symptoma
  9. DiGeorge Syndrome, Symptoma