174 Possible Causes for Leucine Increased

  • Maple Syrup Urine Disease

    Metabolic consequences include: Increased ketoacids - ketosis, metabolic acidosis Increased glucose utilization - ketosis Increased leucine - brain toxicity Acute Presentation[newenglandconsortium.org] Only samples with both increased total leucine and increased alloisoleucine would lead to further metabolic workup.[clinchem.aaccjnls.org] Lab reports documenting signs of increased leucine, isoleucine, allioleucine and valine. There may also be ketosis and acidosis.[secure.ssa.gov]

  • Isovaleric Acidemia

    Isovaleric acid accumulates in the blood during periods of increased amino acid metabolism. Coma and death may occur.[medical-dictionary.thefreedictionary.com] Normal or certainly excessive protein ingestion may produce a similar increase in leucine.[newenglandconsortium.org] […] oral intake and reducing leucine intake by using leucine-free formula or powders for nutrition.[journals.lww.com]

  • HMG-CoA Lyase Deficiency

    This results in increased utilization of glucose with hypoglycemia and accumulation of toxic metabolites.[medicalhomeportal.org] . — Leucine pathway showing different enzymatic blocks and the amino acids that increase as a result of the block.[pediatricneuro.com] Metabolic acidosis with increased anion-gap is typically present, and plasma branch-chain amino acids (leucine, isoleucine, and valine) are seen. Hypoglycemia may occur.[genico.ch]

  • Multiple Carboxylase Deficiency

    . — Leucine pathway showing different enzymatic blocks and the amino acids that increase as a result of the block.[pediatricneuro.com] Amino acids including Leucine degradation produce energy in the form of ketones bodies.[path.upmc.edu] These nonleucine pathway involvements produce: (1) lactic acidosis with an increased lactate-to-pyruvate ratio due to a defect in pyruvate metabolism, (2) propionic acidemia[pediatricneuro.com]

  • Obesity

    Obesity News Prevention Research Matters-Communities Working to Improve Physical Activity - 20-MAR-2018 Details Dr. Sandy Slater, a researcher with the University of Illinois, Chicago Prevention Research Center, discusses how a park improvement project in Chicago helped engage communities to improve areas for play[…][phpartners.org]

  • Viral Hepatitis

    Viral hepatitis is liver inflammation due to a viral infection . ". Rev Prat (in French). 40 (18): 1656–9. PMID 2164704 . Chau TN, Lee KC, Yao H, et al. (February 2004). "SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases". Hepatology . 39 (2): 302–10. doi : 10.1002/hep.20111 . PMID[…][en.wikipedia.org]

  • Juvenile Paget Disease

    […] blood level of alkaline phosphatase * Increased urine level of leucine-amino acid peptidase * Increased urine level of uric acid * Increased blood level of uric acid * Increased[checkorphan.org] […] blood level of leucine-aminopeptidase * Incrdased blood level of hydroxyproline Causes - Juvenile Paget disease The disease occurs worldwide, but is more common in Europe[checkorphan.org] * Enlarged bone ends * Broadened bone shafts * Bowed bone shafts * Pigeon breast * Kyphoscoliosis * Short stature * Walking difficulty * Enlarged head * Dental caries * Increased[checkorphan.org]

  • Diamond-Blackfan Anemia

    Several preclinical studies with DBA lymphocytes exposed to various L-leucine doses, have demonstrated that protein synthesis can be increased by using high doses L-leucine[clinicaltrials.gov] Recent clinical data on L-leucine therapeutic use have demonstrated increase the hemoglobin level and transfusion independence in patients with DBA and 5q-syndrom.[clinicaltrials.gov] These data support the rationale for clinical trial on L-leucine use as a therapeutic agent for DBA patients.[clinicaltrials.gov]

  • Fructose-1,6-Diphosphatase Deficiency

    In the serum alanine was excessive, but also phenylalanine, lysine, proline, valine, threonine, leucine, serine and other amino acids were increased.[dspace.library.uu.nl] Serum methionine was moderately increased, but a striking cystathioninuria was present and once even homocystine was traced in the urine.[dspace.library.uu.nl]

  • Methohexital

    Results After methohexital, significant dose ( 26 μg mL 1 ) as well as duration of exposure–dependent ( 30 min) increases in histidine, isoleucine, leucine, valine, methionine[journals.cambridge.org]

Further symptoms