Possible Causes for Leucine Increased in USA

  • Maple Syrup Urine Disease
    Leucine Increased

    The classic MSUD would present the earliest among neonates from first to second week of life. They may present with lethargy, vomiting, irritability, abnormal movements, poor feeding habits and poor weight gain which are eminently the offshoot of the neurological effects of leucine accumulation in the brain and…[1]

  • Obesity
    Leucine Increased

    In the United States, 36% of the population are clinically obese as of 2010. Obesity remains to be a looming major health crisis internationally where its prevalence rate is increasing rapidly especially in the first world countries worldwide. Obesity is technically defined as having a BMI of more than 30. BMI is an index…[2]

  • HMG-CoA Lyase Deficiency
    Leucine Increased

    HMG-CoA lyase deficiency is a rare genetic disorder characterized by the deficiency of an enzyme that is necessary for the synthesis of ketone bodies and metabolism of leucine, an essential amino acid. Thus, patients present with severe and potentially life-threatening hypoglycemia, ketotic acidosis, hyperammonemia,…[3]

  • Multiple Carboxylase Deficiency
    Leucine Increased

    Multiple carboxylase deficiency is a form of metabolic disorder involving failures of carboxylation enzymes. The deficiency can be in biotinidase or holocarboxylase synthetase. These conditions respond to biotin. Forms include: Holocarboxylase synthetase deficiency - neonatal; Biotinidase deficiency - late onset; If…[4]

  • Isovalericacidemia
    Leucine Increased

    Isovalericacidemia (IVA) is a rare metabolic disorder that is classified under the category of organic acidemias and is characterized by an inborn deficiency of the isovaleryl-CoA dehydrogenase (IVD) enzyme, which mediates leucine catabolism. IVA is usually diagnosed in children and manifests with two types - acute and…[5]

  • Viral Hepatitis
    Leucine Increased

    Viral hepatitis is an inflammatory liver condition that most commonly arises from hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). The prevalence of these viruses varies geographically. The clinical picture of acute viral hepatitis is variable…[6]

  • Huntington's Disease
    Leucine Decreased

    Huntington disease (Huntington's chorea) is an incurable, neurodegenerative, autosomal dominant inherited disorder caused by an elongated CAG repeat on the short arm of chromosome 4p16.3 in the Huntingtine gene. The signs and symptoms of the disease consist of motor, cognitive and psychiatric disturbances. The…[7]

  • Hepatic Encephalopathy
    Leucine Decreased

    Hepatic encephalopathy (HE) is a pathological condition defined by the spectrum of neuropsychiatric abnormalities which result from a liver dysfunction. It is known in the scientific community with a number of different names, such as portosystemic encephalopathy, liver encephalopathy or hepatic coma. HE…[8]

  • Hepatic Veno-Occlusive Disease
    Bilirubin Increased

    Hepatic veno-occlusive disease is a life-threatening condition in which toxic substances (either chemotherapeutic drugs or pyrrolizidine alkaloids found in various herbal remedies) cause severe damage to the endothelial cells of sinusoidal vessels in the liver, resulting in massive fibrosis and blood flow obstruction.…[9]

  • Primary Biliary Cirrhosis
    Bilirubin Increased

    Primary biliary cirrhosis (PBC) is a chronic and progressive disease of the liver which involves destruction of the interlobular bile ducts. In many cases, primary biliary cirrhosis causes no symptoms. However, in certain percentage of individuals this disease is known to cause the following signs and symptoms: Dry…[10]

Further symptoms

Similar symptoms


  1. Maple Syrup Urine Disease, Symptoma
  2. Obesity, Symptoma
  3. HMG-CoA Lyase Deficiency, Symptoma
  4. Wikipedia: Multiple carboxylase deficiency, CC-BY-SA-3.0
  5. Isovalericacidemia, Symptoma
  6. Viral Hepatitis, Symptoma
  7. Huntington's Disease, Symptoma
  8. Hepatic Encephalopathy, Symptoma
  9. Hepatic Veno-Occlusive Disease, Symptoma
  10. Primary Biliary Cirrhosis, Symptoma