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436 Possible Causes for Leukemia, Macrocytic Anemia

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Therapy-related leukemia (myelodysplasia and acute myeloid leukemia-t-MDS/AML) is a well-known complication of conventional chemoradiotherapy used to treat a variety of primary[ncbi.nlm.nih.gov] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[symptoma.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] It may be associated with aplastic anemia, myelodysplastic syndrome, or acute myelogenous leukemia. Risk factors, except for prior aplastic anemia, are not known.[nlm.nih.gov] Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption); Anemia - intrinsic factor; Anemia[mclaren.org]

  • Primary Myelofibrosis

    A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia[ncbi.nlm.nih.gov] Transformation of primary myelofibrosis (PMF) to basophilic leukemia is very rare. We report the case of a 44-year-old man who had had PMF for 6 years.[ncbi.nlm.nih.gov] The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined.[ncbi.nlm.nih.gov]

  • Acute Erythroblastic Leukemia

    : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] This report describes two elderly patients with acute leukemia in which blast cells were undifferentiated with conventional light microscopy (L.M.) and cytochemistry.[ncbi.nlm.nih.gov] Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome[books.google.de]

  • Idiopathic Refractory Anemia

    Macrocytic anemia is usually caused by vitamin d eficiencies, alcohol use, medication s or thyroid.[seer.cancer.gov] Attention is paid to the hematological changes prior to leukemia development.[link.springer.com] Thrombocytopenia ; with impaired primary hemostasis petechial bleeding Hepatosplenomegaly (uncommon) References: [4] Diagnostics CBC with peripheral smear Normocytic or macrocytic[amboss.com]

  • Anemia

    Macrocytic anemia Possible causes of macrocytic anemia include vitamin B-12 deficiency, folate deficiency, liver disease, and hypothyroidism.[emedicine.medscape.com] Toyama K, Ohyashiki K, Yoshida Y, Abe T, Asano S, Hirai H, Hirashima K, Hotta T, Kuramoto A, Kuriya S Leukemia : official journal of the Leukemia Society of America, Leukemia[web.archive.org] The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis.[ncbi.nlm.nih.gov]

  • Diamond-Blackfan Anemia

    Diamond Blackfan anemia (DBA) and myelodysplastic syndrome (MDS) with isolated del(5q) are severe macrocytic anemias; although both are associated with impaired ribosome assembly[ncbi.nlm.nih.gov] Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.[ncbi.nlm.nih.gov] The median survival was 56 years, and the cumulative incidence of solid tumor/leukemia was approximately 20% by age 46 years.[ncbi.nlm.nih.gov]

  • Vitamin B12 Deficiency

    Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[doi.org] […] biopsies are not frequently performed as part of the diagnostic workup and can demonstrate morphologic features that overlap with myelodysplastic syndrome (MDS) and acute leukemia[ncbi.nlm.nih.gov] Chronic myelogenous leukemia, promyelocytic leukemia, polycythemia vera and hypereosinophilic syndrome have all been associated with high B12 levels ( 25 ).[dietvsdisease.org]

  • Refractory Megaloblastic Anemia

    Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.de] Toyama K, Ohyashiki K, Yoshida Y, Abe T, Asano S, Hirai H, Hirashima K, Hotta T, Kuramoto A, Kuriya S Leukemia : official journal of the Leukemia Society of America, Leukemia[atlasgeneticsoncology.org] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com]

  • Severe Aplastic Anemia

    He was then treated with induction therapy using cytosine arabinoside and daunomycin for acute myeloid leukemia, but he succumbed due to infection and refractory leukemia.[ncbi.nlm.nih.gov] The SAA may also recur or a pre-leukemia condition may develop months or years later.[leukemiabmtprogram.com] It is not a cancer although in rare circumstances, it may develop into myelodysplastic syndrome or acute myeloid leukemia.[leukemiabmtprogram.org]

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