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548 Possible Causes for Leukemia, Macrocytic Anemia

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Therapy-related leukemia (myelodysplasia and acute myeloid leukemia-t-MDS/AML) is a well-known complication of conventional chemoradiotherapy used to treat a variety of primary[ncbi.nlm.nih.gov] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[symptoma.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] […] chromosomal abnormalities involving chromosome bands 13q12 to 13q14 (13q12q14) are frequently found in various hematologic malignancies, including chronic lymphoblastic leukemia[ncbi.nlm.nih.gov] […] tur·nal he·mo·glo·bi·nu·ri·a an infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia[medical-dictionary.thefreedictionary.com]

  • Primary Myelofibrosis

    A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia[ncbi.nlm.nih.gov] The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined.[ncbi.nlm.nih.gov] Transformation of primary myelofibrosis (PMF) to basophilic leukemia is very rare. We report the case of a 44-year-old man who had had PMF for 6 years.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    MACROCYTIC anemia with anisocytosis 2. THROMBOCYTOPENIA with variations in PLT size. 3. WBCs may be N/H/L 4.[quizlet.com] There are two big categories of leukemias: acute leukemias and chronic leukemias.[pathologystudent.com] M3 leukemias were rather low in CD11a expression.[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    , may have basophils, platelets Anemia, leukocytosis, or nl platelets platelets, often abnormal Dimorphic RBC, platelets Macrocytic anemia, or nl platelets Marrow Myeloids[surgpathcriteria.stanford.edu] To date, this case is the first description of a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia, presenting with[ncbi.nlm.nih.gov] However, there were also cells indicating hairy cell leukemia.[ncbi.nlm.nih.gov]

  • Systemic Mastocytosis

    anemia and thrombocytopenia.[cedars-sinai.edu] Leukemia 2007; [Epub ahead of print] Google Scholar 12.[link.springer.com] Herein, we report a case of 14-year-old girl with SM associated with acute myeloid leukemia with maturation with t(8;21).[ncbi.nlm.nih.gov]

  • Acute Erythroblastic Leukemia

    : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] This report describes two elderly patients with acute leukemia in which blast cells were undifferentiated with conventional light microscopy (L.M.) and cytochemistry.[ncbi.nlm.nih.gov] An excellent example was case 352 Image 1D , a 20-year-old man who had jaundice and severe macrocytic anemia.[academic.oup.com]

  • Cartilage Hair Hypoplasia

    Laboratory studies will reveal transient macrocytic anemia, lymphopenia with a decreased CD4 /CD8 T-cell count, and neutropenia.[symptoma.com] The leukemia and lymphoma risk comes from the impaired immune system and it’s only about 9% that get leukemia or lymphoma.[recapo.com] In 11 patients, anemia developed before five months of age; one patient developed aplastic anemia at 2.5 years of age, 10 patients had normocytic anemia, but two had macrocytic[jpediatricsreview.com]

  • Pyruvate Kinase Deficiency

    Clinical evaluation of blood from patients with PKLR deficiency will show normocytic anemia (sometimes macrocytic) which is reflective of the reticulocytosis that is invariably[themedicalbiochemistrypage.org] A congenital erythrocyte pyruvate kinase (PK) deficiency was found in a 72-year old female patient with chronic myelomonocytic leukemia (CMML).[ncbi.nlm.nih.gov] Acute macrocytic hemolytic anemia occurring following administration of sulfadiazine. 3. Lab. G? Clin. Med., 29: 347-351, 1944. MANCHESTER,R. C.[kundoc.com]

  • Hereditary Spherocytosis

    There are several reports of polycythemia vera which occurred in patients with macrocytic anemia after treatment with vitamin B12, folic acid, or liver extract. 1-7 We are[jamanetwork.com] Abstract Hereditary spherocytosis (HS) and Chronic myelocytic leukemia (CML) are both life threatening hemotologic diseases.[degruyter.com] MCHC, MCV and RDW aren’t elevated in all anemias…they are different in different anemias.[pathologystudent.com]

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