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40 Possible Causes for Leukocyte Alkaline Phosphatase Decreased, Peripheral Neuropathy

  • Infectious Mononucleosis

    Neurologic complications are rare but may include encephalitis, seizures, Guillain-Barré syndrome, peripheral neuropathy, viral meningitis, myelitis, cranial nerve palsies[merck.com] A diagnosis of acute symmetrical sensorimotor peripheral neuropathy (Guillain-Barré syndrome) was made. The results of CSF cultures were negative.[dx.doi.org] Of note, some of the medications used in the patient's conditioning regimen are potentially nerotoxic: fludarabine can cause mild peripheral neuropathy, encephalopathy, seizures[dx.doi.org]

  • Bronchogenic Carcinoma

    neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net] Neuro-myopathic: Lamber-eaton syndrome (pre-synaptic voltage gated calcium channel antibodies; SOX protein antibody; SCLC associated; treated with 3,4-diaminopyridine), Peripheral[epomedicine.com] neuropathy, superior vena cava syndrome (compression/invasion of SVC causes venous congestion, circulatory compromise, dusky head, arm edema) Spread and classification Spreads[pathologyoutlines.com]

  • Renal Cell Carcinoma

    Patients with irreversible toxicity that is not reasonably expected to be exacerbated by the IMP may be included e.g. hearing loss, peripheral neuropathy etc.[clinicaltrials.gov]

  • Leukemia

    Peripheral neuropathyPeripheral neuropathy, or numbness, tingling or pain in the hands and feet, can last months after therapy with agents such as Oncovin.[hopkinsmedicine.org]

  • Cecal Adenocarcinoma

    Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] […] sensorial neuropathy (12.4% grade 3).[cancer.gov] .023).[ 26 ][ Level of evidence: 1iiA ] Patients treated with FOLFOX-4 experienced more frequent toxic effects consisting mainly of neutropenia (41% grade 3) and reversible peripheral[cancer.gov]

  • Pancreatic Adenocarcinoma

    The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com] Of patients with grade 3 peripheral neuropathy, 44% were able to resume treatment at a reduced dose within a median of 23 days after onset of a grade 3 event.[cancer.gov] Scripture CD, Figg WD, Sparreboom A (2006) Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives. Curr Neuropharmacol 4 : 165–172.[nature.com]

  • Malignant Neoplasm of Pancreas

    […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org] Radiation-induced polyneuropathy, ICD-10-CM Code G62.82, occurs in approximately 1-5% of those receiving radiation therapy. [29] [28] Depending upon the irradiated zone, late effect neuropathy[en.wikipedia.org]

  • Gastric Adenocarcinoma

    neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk] The main toxicities of this regimen were neutropenia, peripheral neuropathy and anaphylaxic reactions.[annonc.oxfordjournals.org]

  • Chronic Lymphocytic Leukemia

    I had bad peripheral neuropathy of the legs after using a small dose of vincristine in 2007; Dr.[clldiary.blogspot.com]

  • Acute Myelocytic Leukemia

    Sleep Better to Feel Better: Tips You Can Use Helping Teachers and Educators Support Siblings of Children with Cancer Understanding Peripheral Neuropathy Survivors Too: Family[cancercare.org]

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