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41 Possible Causes for Leukocyte Alkaline Phosphatase Increased, Polycythemia Vera

  • Myeloproliferative Disease

    Abstract A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a[ncbi.nlm.nih.gov] Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor.[ncbi.nlm.nih.gov] Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. See Workup for more detail.[emedicine.com]

  • Polycythemia Vera

    How is polycythemia vera treated?[symptoma.com] Symptoms Many people with polycythemia vera don't have signs or symptoms.[mayoclinic.com] Polycythemia vera is a rare chronic myeloproliferative disorder. An increase in red cell mass is the primary feature of polycythemia vera (PV).[symptoma.com]

  • Primary Myelofibrosis

    CONTEXT: Megakaryocytes are the "hallmark" of Philadelphia chromosome-negative myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera, and primary[ncbi.nlm.nih.gov] RATIONALE: This case report describes the progression of primary myelofibrosis (PMF) to polycythemia vera (PV), and discuss its potential mechanisms.[ncbi.nlm.nih.gov] Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    For instance, polycythemia vera may be inherited in an autosomal dominant manner and predisposes to myelofibrosis.[symptoma.com] On the one hand, it may be triggered by radiation, infection, and hematological diseases like polycythemia vera, essential thrombocythemia, and leukemia.[symptoma.com] It may be triggered by radiation, pathogens like mycobacteria, human immunodeficiency virus, and fungi, but myelofibrosis may also arise from polycythemia vera, essential[symptoma.com]

  • Leukoerythroblastic Anemia

    The leukocyte alkaline phosphatase score is normal or increased, and the karyotype of remaining normal marrow cells is intact.[medtextfree.wordpress.com] vera; PMF primary myelofibrosis; ET essential thrombocythemia Hematolymphoid Disorders with Thrombocytosis CML PV PMF, Cellular Phase ET RARS-T 5q- Tyrosine kinase ABL p230[surgpathcriteria.stanford.edu] vera; protracted x-ray treatment followed by a myelosclerotic syndrome. ( 14932790 ) ROSELSEN E....OHLSEN S. 1952 16 Metastases in bone marrow and myelophthisic anemia from[malacards.org]

  • Leukemoid Reaction

    Unlike CML, leukocyte alkaline phosphatase is increased and the bcr/abl translocation is absent.[wakemedicine.wordpress.com] vera, and Hodgkin's disease, in active regeneration of the bone marrow, massive hemorrhage, granulocytopenia, diseases of the bone and bone marrow, malignant metastases,[cancerres.aacrjournals.org] The leukemoid reaction is distinguished from chronic myelogenous leukemia by an increased leukocyte alkaline phosphatase, and generally, lack of thrombocytopenia.[pancreas.imedpub.com]

  • Myelodysplasia

    Vera , Fibrotic Phase History of PV / JAK2 Essential Thrombocythemia , Fibrotic Phase (rare) History of ET / may be JAK2 CML , Fibrotic Phase History of CML / BCR-ABL1 MDS[surgpathcriteria.stanford.edu] ICD-10-CM Codes › C00-D49 Neoplasms › D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes › D46- Myelodysplastic syndromes › Myelodysplastic[icd10data.com] Differential Diagnosis Other hematolymphoid disorders Non-neoplastic simulators Hematolymphoid Disorders with Marrow Fibrosis (overview) Disorder Distinguishing Feature(s) Polycythemia[surgpathcriteria.stanford.edu]

  • Essential Thrombocythemia

    Granulocytes from patients with myeloproliferative disorders were previously shown to be functionally activated, as indicated by increased values for leukocyte alkaline phosphatase[dx.doi.org] This review provides our current management strategy of patients with polycythemia vera and ET. Copyright 2016 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov] vera.[doi.org]

  • Acute Erythroblastic Leukemia

    . : Acute erythermic myelosis as a terminal stage of polycythemia vera. Acta path, microbiol. scand. 50 , 156 (1960).[link.springer.com] Three patients had a previous diagnosis of myeloproliferative disorder (one patient with polycythemia vera, one with essential thrombocythemia and one with both polycythemia[doi.org] PubMed CrossRef Google Scholar Eastman , P. , Wallerstein , R.O. , Schrier , S.L. : Conversion of polycythemia vera to chronic Di Guglielmo’s syndrome. J. Amer. med.[link.springer.com]

  • Chronic Lymphocytic Leukemia

    The association of chronic lymphocytic leukemia with polycythemia vera is a rare event with only a few cases of coexistence ever reported.[ncbi.nlm.nih.gov] Polycythemia vera is a Philadelphia chromosome-negative myeloproliferative neoplasm. Chronic lymphocytic leukemia is a monoclonal expansion of a CD5 CD19 B lymphocytes.[ncbi.nlm.nih.gov]

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