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3,031 Possible Causes for Leukocyte Alkaline Phosphatase Increased, Splenomegaly, Wide Space Between the First and Second Toe

  • Non-Hodgkin Lymphoma

    Computed tomography scan of the chest and abdomen showed paratracheal and subcarinal lymphadenopathy and splenomegaly, with the findings being compatible with lymphoma.[ncbi.nlm.nih.gov] Splenomegaly. Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info] Splenomegaly is observed in approximately 40% of patients; the spleen is rarely the only involved site at presentation.[emedicine.medscape.com]

    Missing: Wide Space Between the First and Second Toe
  • Portal Cirrhosis

    Liver cirrhosis: Liver cirrhosis with an inhomogeneous liver with irregular contour and ascites and splenomegaly Liver cirrhosis: Liver cirrhosis with an irregular liver contour[ultrasoundcases.info] Splenomegaly (enlarged spleen) e. Hepatic encephalopathy (drowsiness or confusion due to inability of the liver to break down toxins in the blood) f.[singhealth.com.sg] DIAGNOSIS Can be asymptomatic for decades History Physical findings: Hepatomegaly, jaundice, ascites, spider angioma, splenomegaly, palmar erythema, fetor hepaticus, purpura[slideshare.net]

    Missing: Wide Space Between the First and Second Toe
  • Leukoerythroblastic Anemia

    leukocyte alkaline phosphatase: 100 score; increased vitmain B12 900 pg/mL or B12 binding protein 2200 pg/mL Treatment of polycythemia vera phlebotomy to reduce hyperviscosity[memorize.com] Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases.[merckmanuals.com] alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com]

    Missing: Wide Space Between the First and Second Toe
  • Down Syndrome

    Ultrasound features indicative of TAM included hepatomegaly splenomegaly (79.5%), hydrops fetalis (30.8%), pericardial effusion (23.1%) and aberrant liquor volume (15.4%).[ncbi.nlm.nih.gov] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Tc1 mice have macrocytic anaemia, and older animals show splenomegaly with increased megakaryopoiesis and erythropoiesis, but they do not develop acute leukaemia, even when[doi.org]

  • Myeloproliferative Disease

    A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a 64-yr-old[ncbi.nlm.nih.gov] CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] Leukocyte alkaline phosphatase ( 100 units in the absence of fever or infection). There is no staging system for this disease.[northshore.org]

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  • Primary Myelofibrosis

    alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov]

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  • Polycythemia Vera

    leukocyte alkaline phosphatase , increased vit.B12 level, decreased folic acid level, elevated alk.phosphatase & conjungated bilirubin, hypercalcemia.[enotes.tripod.com] […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] JAK2 V617F is the basis for many of the phenotypic and biochemical characteristics of PV, such as elevation of the leukocyte alkaline phosphatase (LAP) score and increased[theoncologyinstitute.com]

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  • Chronic Lymphocytic Leukemia

    One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[symptoma.com] Patients may sometimes present with hepatomegaly, splenomegaly or both and/or hemolytic anemia.[radiopaedia.org]

    Missing: Wide Space Between the First and Second Toe
  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and[ncbi.nlm.nih.gov] Rare splenomegaly Prominent splenomegaly Does not meet criteria for MDS or PV Commonly multilineage dysplasia and increased blasts History of polycythemia vera Myelofibrosis[surgpathcriteria.stanford.edu]

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  • Septicemia

    Septicemia due to Pasteurella (Mannheimia) haemolytica is a rare occurrence. We report a fatal case of M. haemolytica septicemia in a seven-month-old infant who presented with prolonged fever, sepsis, and pneumonitis without discernable preceding history of animal bites or contact. Rare cases of systemic Mannheimia[…][ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe

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