Leukocytes Decreased: Causes & Reasons

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Possible Causes for Leukocytes Decreased

Leukopenia

(decreased white blood cells in blood) Leukopenia not chemotherapy or radiation related Leukopenia, not chemotherapy or radiation related Applies To Decreased leukocytes, [icd9data.com]

Code Applicable To Decreased leukocytes, unspecified Leukocytopenia, unspecified Leukopenia Type 1 Excludes malignant leukopenia ( D70.9 ) basophilic D72.818 ICD-10-CM Diagnosis [icd10data.com]

This results in the decrease in the level of leukocytes. [hxbenefit.com]

Chédiak-Higashi Syndrome

This rare autosomal recessive disorder is characterized by partial oculocutaneous albinism, decreased leukocyte chemotaxis, susceptibility to infection, and death in childhood [ncbi.nlm.nih.gov]

Partial albinism, pan-leukocytic giant granules, and profoundly decreased NK-cell activity were compatible with childhood CHS, but apparently normal neutrophil function prolonged [ncbi.nlm.nih.gov]

Rebuck skin windows showed a decreased accumulation of leukocytes at an inflammatory site. [jci.org]

Acute Alcohol Intoxication

and decreased platelet function. [medical-dictionary.thefreedictionary.com]

Intoxication depresses leukocyte movement into areas of inflammation, depresses platelet function, and leads to fibrinogen and clotting factor deficiency, thrombocytopenia [medical-dictionary.thefreedictionary.com]

Niemann-Pick Disease

Acid sphingomyelinase activities of peripheral blood leukocytes were significantly decreased (4.05-21.9 nmol/h/mg protein, normal range 216.1-950.9 nmol/h/mg protein). [ncbi.nlm.nih.gov]

Mean annual decreases in platelet count and leukocyte count were 7 × 10 3 and 0.2 × 10 3 per mm 3, respectively. [pediatrics.aappublications.org]

On laboratory testing, there is a decrease in high-density lipoprotein (HDL)- cholesterol, elevated triglycerides, and an increase in LDL-cholesterol. [step2.medbullets.com]

Agranulocytosis

[…] in the number of neutrophilic leukocytes in the blood 288.0 Excludes Applies To Decreased Absolute Neutrophil Count (ANC) Use Additional Use additional code for any associated [icd9data.com]

[…] white blood cell count, unspecified 2016 2017 2018 2019 Billable/Specific Code Applicable To Decreased leukocytes, unspecified Leukocytopenia, unspecified Leukopenia Type [icd10data.com]

Clinical Information A deficiency in the number of granulocytes, a type of white blood cell An abnormal decrease in the number of neutrophils, a type of white blood cell Decrease [icd9data.com]

Lymphopenia

After complete parasite clearance a significant rise in total leukocyte count and lymphocyte count and a significant decrease in NLCR was observed. [ncbi.nlm.nih.gov]

D72.8 Other specified disorders of white blood cells D72.81 Decreased white blood cell count D72.810 Lymphocytopenia D72.818 Other decreased white blood cell count D72.82 [icd10data.com]

[…] neutropenia D70.9 Neutropenia, unspecified D71 Functional disorders of polymorphonuclear neutrophils D72 Other disorders of white blood cells D72.0 Genetic anomalies of leukocytes [icd10data.com]

Isovaleric Acidemia

[…] blood leukocyte number Low white blood cell count [ more ] 0001882 Pancytopenia Low blood cell count 0001876 Thrombocytopenia Low platelet count 0001873 Vomiting Throwing [rarediseases.info.nih.gov]

[…] hypocellularity Bone marrow failure 0005528 Coma 0001259 Dehydration 0001944 Hyperglycinuria High urine glycine levels 0003108 Ketoacidosis 0001993 Lethargy 0001254 Leukopenia Decreased [rarediseases.info.nih.gov]

Toxoplasmosis

During treatment with pyrimethamine, leukocyte and platelet counts should be monitored weekly. [en.wikipedia.org]

"Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: a phase I pilot study". [en.wikipedia.org]

Folinic acid protects against the decrease in platelets and white blood cells induced by pyrimethamine. [en.wikipedia.org]

Acute Promyelocytic Leukemia

During ATO treatment, both patients' plasma PA activity and uPAR on leukocytes gradually increased, annexin II on leukocytes increased initially and decreased afterwards, [ncbi.nlm.nih.gov]

[…] from WBC consumption of O2, coined “leukocyte larceny” by Dr. [errolozdalga.com]

[…] bleeding Nosebleed [ more ] 0000421 Exertional dyspnea 0002875 Fatigue Tired Tiredness [ more ] 0012378 Fever 0001945 Gingival bleeding Bleeding gums 0000225 Leukopenia Decreased [rarediseases.info.nih.gov]

Propionic Acidemia

OTC deficiency was diagnosed on the basis of: 1) decreased enzyme activity in leukocytes;2) hyperammonemia in response to protein intakes in excess of 2.0 g/kg/day; 3) orotic [ncbi.nlm.nih.gov]

OTC deficiency was diagnosed on the basis of:1) decreased enzyme activity in leukocytes; 2) hyperammonemia in response to protein intakes in excess of 2.0 g/kg/day; 3) orotic [academic.oup.com]

Within a week of antibiotic therapy, the CSF leukocyte count decreases and the differential count shifts back to lymphocytes and monocytes. [mbtshoeswomen.us]

Cyclic Neutropenia

[…] normal leukocyte count.[5] Berardinis and Reiman in 1949 suggested the cause to be an autosomal dominant inheritance which was later confirmed by Morley et al. in 1967. [ijabmr.org]

There are additionally many other causes for the decrease of leukocytes (4-11 mm3) in the blood. [elsevier.es]

D72.8 Other specified disorders of white blood cells D72.81 Decreased white blood cell count D72.818 Other decreased white blood cell count Reimbursement claims with a date [icd10data.com]

Pernicious Anemia

Decreased numbers and immaturity of white blood cells ( leukocytes ) and blood platelets (thrombocytes) may also occur. [diagnose-me.com]

Leukemia

Some combinations of 6-mercaptopurine with other chemotherapy drugs have produced results such as decrease in organ size and increase or normalization of platelet and leukocyte [web.archive.org]

The drug was well tolerated, and responses were rapid as judged by the decrease in the leukocyte count. [web.archive.org]

Acute Myeloid Leukemia

Conclusions : There is significant improvement of hemoglobin, trombocytes and decrease of leukocytes level during chemotherapy. The mean survival time was 273.2 days. [apjpch.com]

Myelodysplasia

CD10 on neutrophils in MDS; (5) changes in a variety of leukocyte activation antigens, including FcRI, FcRII, and FcRIII, in MDS; (6) greater variability in the expression [wiki.clinicalflow.com]

For prognostic follow up, the increase expression of CD33, CD34, CD13, HLA-DR/human leukocyte antigen-DR and decreased reactivity for CD11b in the bone marrow have been associated [intechopen.com]

myeloblasts may be increased but < 20% of nonerythroid cells (or is defined as AML); abnormally localized immature precursors (ALIP), neutrophils with decreased secondary [pathologyoutlines.com]

Aplastic Anemia

Improving the success rate and decreasing the complication of BMT depends on finding the best human leukocyte-associated antigens (HLA) match. [my.clevelandclinic.org]

Systemic Mastocytosis

[…] blood leukocyte number Low white blood cell count [ more ] 0001882 Osteoporosis 0000939 Skin rash 0000988 Thrombocytopenia Low platelet count 0001873 5%-29% of people have [rarediseases.info.nih.gov]

0001903 Generalized osteosclerosis 0005789 Impaired temperature sensation Abnormality of temperature sensation Loss of temperature sensation [ more ] 0010829 Leukopenia Decreased [rarediseases.info.nih.gov]

Systemic Lupus Erythematosus

It decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability. 11. [slideshare.net]

Decreased IL-12 production by polymorphonuclear leukocytes in patients with active systemic lupus erythematosus. Immunol Invest 2002;31:177–89 106. [journals.lww.com]

Congenital AIDS

[…] chemotaxis that results in decreased phagocyte activity Etiology Autosomal recessive inheritance Absence of the ß2-integrin leukocyte adhesion surface molecule LFA-1 (CD18 [amboss.com]

Hypergammaglobulinemia Genotyping is confirmatory Treatment Leukocyte adhesion deficiency type 1 (LAD1) Definition: : genetic condition characterized by a defect in the leukocytic [amboss.com]

[…] respiratory burst in neutrophils Recurrent, severe infections with catalase-positive organisms Anemia and lymphadenopathy Possible skin granulomas Abnormal DHR test: absent or decreased [amboss.com]

Hypersplenism

As a disorder, hypersplenism typically involves a distended spleen (splenomegaly), decreased levels of leukocytes, erythrocytes and platelets, shorter platelet and erythrocyte [symptoma.com]

and platelets, resulting in mild-to-moderate decreases in some or all of these cell lines. [emedicine.medscape.com]

[30] In patients with cirrhosis, abnormalities of cytokine production may contribute to the cytopenias noted. [20] As the spleen enlarges, it can sequester erythrocytes, leukocytes [emedicine.medscape.com]

Pseudomonas Pneumonia

[…] protease inhibitor and antimicrobial protein, is decreased with advanced age. [anesthesiology.pubs.asahq.org]

J Respir Crit Care Med 2001; 164:464–8Palmer, L Albulak, K Fields, S Filkin, A Simon, S Smaldone, G Shugars DC, Watkins CA, Cowen HJ: Salivary concentration of secretory leukocyte [anesthesiology.pubs.asahq.org]

Gaucher Disease

However, an enzyme panel will demonstrate decreased or absent activity of the characteristic lysosomal β-glucosidase (glucocerebrosidase) in leukocytes, whereas enzyme activity [archivesofpathology.org]

All patients were diagnosed with GD based on decreased GBA activity in peripheral leukocytes or on genetic testing. [ncbi.nlm.nih.gov]

[…] measurement of Glucocerebrosidase activity in peripheral blood leukocytes. [slideshare.net]

Pulmonary Sarcoidosis

Similar to the AUF1 protein, we observed the decreased expression of HuR protein in our patients with sarcoidosis. [journals.plos.org]

In the healthy lung and in leukocytes, RBPs are more highly expressed than microRNAs and even than transcription factors, possibly indicating the importance of RBPs in monitoring [journals.plos.org]

Acquired Immunodeficiency Syndrome

[…] expression of the homing markers in the GALT is decreased because there is damage to its integrity; the damage results in bacterial translocation which causes a systemic [radiopaedia.org]

Reasons for this are: spread of the HIV-1 to the thymus and/or bone marrow affects the rate of differentiation of T cells and other leukocytes resulting in pan-leukocytopaenia [radiopaedia.org]

Paroxysmal Nocturnal Hemoglobinuria

[…] red blood cells Folate/Iron Supplementation (see Folate, [[Folate]] and Iron, [[Iron]]) Usually Required Prednisone (see Prednisone, [[Prednisone]]) Decreases Complement [mdnxs.com]

[…] patient’s complement-sensitive red blood cells) Measures to Minimize Risk of Hemolysis with Red Blood Cell Transfusion Use washed red blood cells Use packed red blood cells Leukocyte-deplete [mdnxs.com]

B-Cell Acute Lymphoblastic Leukemia

The white blood cell count varies from decreased to sharply increased (7). [jbpml.org.br]

Remission duration and overall survival have decreased in almost every adult ALL trial as the ages of the patient groups have increased. [cancernetwork.com]

Both the proportion of patients receiving radiation and the dose of radiation administered has decreased over the last 2 decades. [cancer.gov]

Hepatitis B

From individual peptide level to the human leukocyte antigen I (HLA-I)-restricted population level, we elucidated that the mutations in these well-defined HLA-I-restricted [ncbi.nlm.nih.gov]

T-cell epitopes significantly decreased antiviral activity-specific CTLs and were positively associated with clinical parameters and disease progression in HBV-infected patients [ncbi.nlm.nih.gov]

Chronic Myelomonocytic Leukemia

After the start of vaccination, the leukocyte and monocyte counts (13,780/microL and 1930/microL, respectively) gradually decreased to within the normal range in association [ncbi.nlm.nih.gov]

Leukocyte and platelet counts remained stable, but anemia persisted, necessitating repeated packed cell transfusions. [dovepress.com]

Serum creatinine level subsequently decreased to 1.93 mg/dL. The patient’s clinical condition steadily improved and fever subsided. [dovepress.com]

Sideroblastic Anemia

No deletion could be detected in mtDNA of leukocytes from her mother and young brother, indicating the sporadic occurrence of this deletion. [doi.org]

[…] of CSF leukocyte count at 36 and 60 months (p = 0.0026 and 0.0076) Hoffman et al. 2012 [58] Open-label rilonacept 101 CAPS (FCAS or MWS) 18 Mean key symptom score at week [ncbi.nlm.nih.gov]

Leukocytes and platelets are normal. Bone marrow shows erythroid hyperplasia with a maturation arrest. [en.wikipedia.org]

Dengue Fever

[…] of leukocytes and platelets. [ncbi.nlm.nih.gov]

[…] bitten by mosquitoes, a 60-year-old Japanese female exhibited positive serologic tests of immunoglobulin M and G enzyme immunoassays for dengue viral infection along with a decrease [ncbi.nlm.nih.gov]