Leukocytosis: Causes & Reasons

Possible Causes for Leukocytosis

We conclude that physicians should consider the diagnosis of tubo-ovarian abscess in the differential diagnosis of abdominal pain, fever and leukocytosis after ovum retrieval [ncbi.nlm.nih.gov]

Laboratory data, including blood count and electrolytes, showed leukocytosis and azotemia. [ncbi.nlm.nih.gov]

[…] using a copper IUD for contraception with poorly controlled type II diabetes mellitus was admitted for suspected tubo-ovarian abscess on the basis of abdominopelvic pain, leukocytosis [ncbi.nlm.nih.gov]

Ascending Cholangitis

Laboratory evaluation is notable for a leukocytosis and a total bilirubin of 6.4 mg/dL. What is the diagnosis in this patient? [medbullets.com]

There is usually a leukocytosis, and the alkaline phosphatase and bilirubin levels are generally elevated. [ncbi.nlm.nih.gov]

A complete blood count (CBC) will almost always show leukocytosis, whereas inflammatory parameters - C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen [symptoma.com]

Schnitzler Syndrome

Monoclonal gammopathy, lymphadenopathy, leukocytosis, and elevated serum inflammatory markers are also seen.2 Patient 1 demonstrated both of the major diagnostic criteria, [jddonline.com]

[…] least two of the following components: fever, arthralgia or arthritis, bone pain, hepato- and/or splenomegaly, lymphadenopathy, elevated erythrocyte sedimentation rate, leukocytosis [jhu.pure.elsevier.com]

[…] least two additional minor symptoms (arthralgia, bone pain, fever of uncertain origin, hepato- or splenomegaly, lymphadenopathy, increased erythrocyte sedimentation rate, leukocytosis [ncbi.nlm.nih.gov]

Primary Myelofibrosis

Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD). [ncbi.nlm.nih.gov]

62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia and leukocytosis [ncbi.nlm.nih.gov]

She has a normal platelet count of 189,000 and she has leukocytosis with a white-blood cell count of 19,000. [targetedonc.com]

Myeloproliferative Disease

Leukocytosis is also found in patients with essential thrombocythemia (primary thrombocythemia). [medindia.net]

Mice developed a completely penetrant myeloproliferative syndrome characterized by leukocytosis with normal maturation of myeloid lineage cells; myeloid hyperplasia in bone [ncbi.nlm.nih.gov]

[…] abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis [icd9data.com]

Chorioamnionitis

[…] clinical criteria for chorioamnionitis found in preterm or term women include maternal fever combined with 2 or more findings of maternal tachycardia, fetal tachycardia, leukocytosis [ncbi.nlm.nih.gov]

This value exceeds the 80th percentile for normal leukocytosis in pregnancy. [clinicaladvisor.com]

Thirteen days after the diagnosis of PPROM (28 weeks and four days) she developed chills, abdominal pain, sub febrile fever, tachycardia, leukocytosis and fetal tachycardia [ncbi.nlm.nih.gov]

Adult-Onset Still Disease

Salmon-colored and usually on the trunk – Leukocytosis: Present in 72-91%. PMN predominant. – Arthralgias: With or without synovitis. Occurs in 72-95% of patients. [utswim.wordpress.com]

[…] systemic inflammatory disease which presents with cardinal symptoms of spiking fever, arthralgia, and characteristic non pruritic evanescent salmon pink rash and neutrophilic leukocytosis [ncbi.nlm.nih.gov]

AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy, and a neutrophilic leukocytosis [ncbi.nlm.nih.gov]

Systemic Juvenile Idiopathic Arthritis

In both children and adults the clinical picture includes arthritis, fever, fatigue, rash, leukocytosis, adenopathy, and hepatosplenomegaly. [medscape.com]

Blood cell count for improvement in leukocytosis and thrombocytosis. [clinicaladvisor.com]

On the basis of this diagnosis, the patient began receiving prednisone, 20 mg twice daily; joint inflammation, fatigue, fever, anemia, leukocytosis, and thrombocytosis rapidly [medscape.com]

Sweet Syndrome

Sweet, contemporary Brit. physician] A febrile illness with raised painful plaques on the limbs, face, and neck; neutrophilic leukocytosis; and dense neutrophilic infiltrates [medical-dictionary.thefreedictionary.com]

[…] disease characterized by dark-red and slowly growing painful papules and plaques particularly on the face and the extremities accompanied by high fever and neutrophilic leukocytosis [dermis.net]

Both diagnoses are characterized by an acute onset of fever, leukocytosis, and tender, erythematous infiltrated plaques. [ncbi.nlm.nih.gov]

Polycythemia Vera

[…] the leukocytosis. [onclive.com]

During multivariable analysis, leukocytosis ⩾15 × 10 9 /l, palpable splenomegaly and ⩾grade 1 BM reticulin fibrosis remained significant. [ncbi.nlm.nih.gov]

Usually, the presence of splenomegaly or leukocytosis or thrombocytosis establishes the diagnosis. [jhu.pure.elsevier.com]

Subcutaneous Abscess

Complementary exams showed leukocytosis. Septic arthritis and bacteraemia was suspected and administration of antibiotic was started after blood culture. [clinmedjournals.org]

[…] immunocompromised states from diabetes, AIDS, asplenia, or blood dyscrasias; recurrent cases of abscess and cellulitis; and systemic signs and symptoms of infection such as fever or leukocytosis [emedicine.medscape.com]

Complementary tests showed leukocytosis and trombocitopenia, liver and canalicular enzymes were above normal limits. HBV, HCV and HIV serologies were negatives. [clinmedjournals.org]

Leukemoid Reaction

Leukocytosis, unspecified, leukocytosis (diagnosis), leukocytosis, Leucocytosis NOS, Leukocytosis, Leukocytosis NOS, Leukocytosis [Disease/Finding], leucocytosis, leukocytoses [fpnotebook.com]

o Neutrophilic leukocytosis is commonly seen in infection, stress, smoking, pregnancy, and following exercise. [errolozdalga.com]

Leukocytosis Leukocytosis : Leukemoid Reactions A leukemoid reaction is a reactive neutrophilia that occurs in response to an infection, inflammatory process, or malignancy [tcd.ie]

Leukostasis

A more recent article on leukocytosis is available. [aafp.org]

o Neutrophilic leukocytosis is commonly seen in infection, stress, smoking, pregnancy, and following exercise. [errolozdalga.com]

This leukocytosis, which was much more pronounced than any of the reported cases of HCL with leukocytosis, was associated with leukostasis in the cerebral vasculature and [ncbi.nlm.nih.gov]

Chronic Phase of Chronic Myeloid Leukemia

Ten months later, he presented with fevers and leukocytosis (WBC, 109.7 × 10 9 /L), with >20% blasts. [bloodjournal.org]

[…] and hypercellular marrow Peripheral blood leukocytosis Granulocytes at all stages of maturation Two peaks: segmented neutrophils and myelocytes Basophilia Eosinophilia (frequent [surgpathcriteria.stanford.edu]

Important diagnostic features are severe leukocytosis (up to > 500,000/μl ), basophilia, and extreme splenomegaly. [amboss.com]

Familial Myelofibrosis

A correlation between leukocytosis and risk of acute leukemia has been recently reported in patients with PV. 24 These data indicate that PV patients with leukocytosis are [bloodjournal.org]

Leukocytosis, anemia, thrombocytopenia, tear drop cells, nucleated RBCs, and myeloblasts were observed in both complete blood cell counts and peripheral blood smears. [koreamed.org]

In conclusion, leukocytosis at diagnosis of PV is a risk factor for evolution in post-PV MF. [bloodjournal.org]

Phlegmon

[…] phlegmon had a higher incidence of severe pancreatitis as defined by Ranson's criteria, presence of an abdominal mass, as well as a longer duration of fever, abdominal pain and leukocytosis [uthscsa.influuent.utsystem.edu]

Elevation of the tongue, difficulty in eating and swallowing, edema of the glottis, fever, rapid breathing, and moderate leukocytosis are the most common symptoms. 3, record [btb.termiumplus.gc.ca]

[…] here is also called Ludwig’s angina) dental pain fatigue ear pain confusion swelling of tongue and neck difficulty breathing Pancreas fever increase in white blood cells (leukocytosis [healthline.com]

Toxic Megacolon

Presented is a middle-aged male who developed a fulminant case of antibiotic-associated pseudomembranous colitis characterized by leukocytosis, hypoalbuminemia, ascites, and [ncbi.nlm.nih.gov]

A 72-year-old woman without significant medical history was admitted with abdominal pain, high fever, leukocytosis, bloody diarrhea and marked dilation of the transverse, [ncbi.nlm.nih.gov]

[…] tachycardia, fatigue, dehydration, ↓ bowel sounds, tympany, rebound tenderness, hypotension Contributing factors Laxatives, opiate use, anticholinergics, hypopotassemia Lab Leukocytosis [medical-dictionary.thefreedictionary.com]

Essential Thrombocythemia

leukocytosis. [scilit.net]

Vascular events were significantly more common in the patients with leukocytosis (leukocyte count >10 x [10.sup.9] [L.sup.-1]) than in those without leukocytosis (leukocyte [go.gale.com]

[…] with leukocytosis (24%, 54/224), the patients with low thrombocytosis (27%, 71/266), and the patients with both low thrombocytosis and leukocytosis (34%, 20/59). [ashpublications.org]

Embolic Mesenteric Infarction

Laboratory values are notable for a leukocytosis and a lactic acid of 6.8 mmol/L. An ECG is shown in Figure A. What is the next best step in diagnosis? [medbullets.com]

Nonspecific laboratory findings include leukocytosis, elevated lactate, hemoconcentration, and metabolic acidosis. [acgcasereports.gi.org]

[…] classically, +/- abd bruit Hypovolemia, possible shock +/- signs of obstruction (abd distension, tympani& borborygmi) Labs/Tests No single lab test can aid in diagnosis CBC (+/- leukocytosis [fprmed.com]

Appendicitis

Blood test results revealed leukocytosis. [ncbi.nlm.nih.gov]

Although early phase of acute appendicitis cannot induce systemic inflammatory responses, it may induce proliferation immature granulocyte before leukocytosis is occurred. [ncbi.nlm.nih.gov]

On admission, the patient was in septic shock with leukocytosis and elevation of C-reactive protein. Among other diagnoses, necrotizing fasciitis was suspected. [ncbi.nlm.nih.gov]

Splenic Infarction

A post hoc analysis demonstrated that single infarcts were more likely to be associated with fever (20% vs. 63%, p < 0.05) and leukocytosis (75% vs. 33%, P = 0.06) CONCLUSIONS [ncbi.nlm.nih.gov]

Patients who are having a sickle cell crisis may have an associated marrow response (leukocytosis, reticulocytosis). [cmaj.ca]

Associated symptoms, leukocytosis or increased serum lactate dehydrogenase occurred inconsistently (∼25% each). [ncbi.nlm.nih.gov]

CINCA Syndrome

Laboratory: BSG: 50/110, CRP 65 mg/l, neutrophil leukocytosis, lymphopenia, erythrocyturia, discrete serum amyloid A elevation. [altmeyers.org]

Relevant laboratory findings included mild leukocytosis, iron resistants hypochromic anemia of chronic disease, elevated ESR and no detectable autoimmune profile. [jacionline.org]

[…] or climate regularly causes systemic inflammatory reaction Fever Cold urticaria (About 7 hours after cold exposure) Conjunctival redness (in eyes) Significant joint pain Leukocytosis [bindevevssykdommer.no]

Renal Infarction

The majority of reported cases have presented with laboratory abnormalities, most notably leukocytosis and elevated lactate dehydrogenase (LDH). [ncbi.nlm.nih.gov]

Leukocytosis (>10 × 10(9)/L) and elevated lactate dehydrogenase levels (>620 IU/L) were the most prominent laboratory findings. [ncbi.nlm.nih.gov]

At presentation, 20 patients (86.9%) had elevated serum lactate dehydrogenase (LDH), 18 patients (78.2%) had leukocytosis, and 16 patients (69.5%) had microscopic hematuria [ncbi.nlm.nih.gov]

Alcoholic Hepatitis

Although a leukocytosis of 15,000-18,000 cells/mm(3) is frequently seen in AH, LRs are rare in this context. [ncbi.nlm.nih.gov]

However, treatment of leukocytosis that causes cytokinemia and hepatic inflammation in patients via granulocytapheresis and leukocytapheresis showed promising results in a [ncbi.nlm.nih.gov]

Laboratory data showed leukocytosis with a predominance of polymorphonuclear leukocytes, and a decline in coagulability. [ncbi.nlm.nih.gov]

Acute Promyelocytic Leukemia

The dynamic changes in leukocytosis showed a single peak wave in all the patients, and the median time to peak was 10 (range 2-26) days. [ncbi.nlm.nih.gov]

Moreover, nine of the 37 patients (24.3%) who presented with leukocytosis at their baseline had complete p15 gene methylation as well (p < 0.05). [ncbi.nlm.nih.gov]

RAS is characterized by unexplained fever, dyspnea, pulmonary infiltrate, leukocytosis and nephropathy. [ncbi.nlm.nih.gov]

Renal Abscess

Renal abscesses must be suspected in children with loin pain, fever and leukocytosis. They may heal even without hospitalization and drainage. [ncbi.nlm.nih.gov]

Fever, loin pain, and leukocytosis were common presenting features, but less than half of all abscesses were associated with either an abnormal urinalysis or a positive urine [ncbi.nlm.nih.gov]

Laboratory studies revealed leukocytosis and thrombocytopenia in 2/3 of the patients. [ncbi.nlm.nih.gov]

Blast Phase of Chronic Myeloid Leukemia

Patients with leukocytosis should be closely monitored. [ncbi.nlm.nih.gov]

Ten months later, he presented with fevers and leukocytosis (WBC, 109.7 × 10 9 /L), with >20% blasts. [bloodjournal.org]

Ten months later, he presented with fevers and leukocytosis (WBC, 109.7 × 109/L), with >20% blasts. [imagebank.hematology.org]

Colonic Diverticulosis

Abscess formation should be suspected when fever, leukocytosis, or both persist despite an adequate trial of appropriate antibiotics. [aafp.org]

Diverticulitis Perforation of diverticulum with pericolic abscess of varying size; not simply inflammation of a tic Clinical Findings Pain and tenderness, mass in LLQ Fever, leukocytosis [learningradiology.com]

Fever and leukocytosis generally are present. Other commonly associated symptoms include nausea, vomiting, and constipation or diarrhea. [aafp.org]

Chronic Myeloid Leukemia

Her disease was managed during pregnancy using interferon-α alone despite persistent leukocytosis. [ncbi.nlm.nih.gov]

One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly. [ncbi.nlm.nih.gov]

It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. [icd9data.com]

Pyelonephritis

Other diagnostic findings are leukocytosis, CVAT or flank pain, and WBC casts in the urine. [getthediagnosis.org]

In urine analyse, pyuria was positive in 6 patients (46.15%) and leukocytosis was detected in one patient (7.7%). [ncbi.nlm.nih.gov]

Clinical symptoms of XGN are non-specific and vary: fever, dysuria, pyuria, leukocytosis, and flank pain. [jbsr.be]