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347 Possible Causes for Leukocytosis, Limb Pain, Splenomegaly

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).[ncbi.nlm.nih.gov] After 26 years of follow-up, the patient reported onset of acute pain at the proximal region of the left upper limb.[ncbi.nlm.nih.gov]

  • Infective Endocarditis

    This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation[ncbi.nlm.nih.gov] CASE PRESENTATION: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis.[ncbi.nlm.nih.gov] PATIENT CONCERN: A 42-year-old woman was admitted to our hospital because of fever, abdominal pain, headache, and right limb weakness.[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] During multivariable analysis, leukocytosis 15 10 9 /l, palpable splenomegaly and grade 1 BM reticulin fibrosis remained significant.[ncbi.nlm.nih.gov] […] change in your PV: • Persistent changes in vision or difficulty with speech • Weakness or numbness on one side of the body • Chest discomfort or difficulty breathing • Severe pain[cancercare.org]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] a Philadelphia (Ph) chromosome without DNA breakpoints in the M-bcr region; (3) the spontaneous loss of detectable Ph-positive cells, 5 years after the first finding of leukocytosis[ncbi.nlm.nih.gov] Leukocytosis is also found in patients with essential thrombocythemia (primary thrombocythemia).[medindia.net]

  • Subacute Bacterial Endocarditis

    Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission.[ncbi.nlm.nih.gov] Laboratory studies may show anemia, leukocytosis, elevated erythrocyte sedimentation rate (ESR), and microscopic hematuria.[symptoma.com] Findings compatible with both SBE and marantic endocarditis due to a B-cell lymphoproliferative disorder included an elevated ESR, and splenomegaly.[ncbi.nlm.nih.gov]

  • Acute Myelocytic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] Thus, the bone marrow and peripheral blood are characterized by leukocytosis with a predominance of immature cells, primarily blasts.[ncbi.nlm.nih.gov] Additional karyotype abnormalities evolved increasingly, and leukocytosis with blasts with more complex karyotypic abnormalities appeared 5 months later.[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia

    Splenomegaly and thrombocytopenia were frequently observed more in CD200 patients. Increased frequency of CD34 was associated with CD200 and CD56 patients.[ncbi.nlm.nih.gov] , hematological, and immunocytological) parameters pointed towards a diagnosis of Wilms tumor in our case, the subsequent development of thrombocytopenia and lymphocytic leukocytosis[ncbi.nlm.nih.gov] We report a case of a 3 years old boy who presented with prolonged fever, nausea, vomiting and increasing lower limbs pain.[ncbi.nlm.nih.gov]

  • Bacterial Endocarditis

    The condition is characterized by heart murmur, prolonged fever, bacteremia, splenomegaly, and embolic phenomena.[medical-dictionary.thefreedictionary.com] These tests may reveal leukocytosis, anemia, elevated ESR, and positive RF.[symptoma.com] […] weakness in the face or limbs suggestive of a stroke.[ahajournals.org]

  • Familial Myelofibrosis

    Amelioration of splenomegaly and anaemia was also observed in mice treated with Elo and Rom than Rom alone.[jshem.or.jp]

  • Sickle Cell Disease

    In two mouse SCD models, Berkeley and SAD, inhibition of red blood cell dehydration and sickling was achieved with correction of hematological parameters, splenomegaly, and[ncbi.nlm.nih.gov] Leukocytosis or erythema does not accompany the swelling.[emedicine.medscape.com] We describe an adolescent boy presenting with limb pain, difficulty in mobilisation, with progressive loss of motor function and later bulbar weakness.[ncbi.nlm.nih.gov]

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