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947 Possible Causes for Leukocytosis, Metabolic Acidosis

  • Pneumonia

    Tissue hypoxia leads to anaerobic metabolism, which causes metabolic acidosis.[] Empyema is potentially more serious and presents as the persistence of fever and leukocytosis after 4-5 days of appropriate antibiotic therapy.[] As the patient’s respiratory rate increases to compensate for metabolic acidosis, excess CO2 is eliminated. Normal end-tidal CO2 level is between 35 and 45 mm Hg.[]

  • Adrenal Insufficiency

    The patient presented after birth with cardiopulmonary instability, hyponatremia, hyperkalemia, hypoglycemia and metabolic acidosis.[] […] vasoconstrictors Opposition to increases in capillary permeability Inhibition of interleukin-2 (IL-2) production by macrophages Stimulation of polymorphonuclear neutrophil (PMN) leukocytosis[] ; with normal saline to treat hypotension ; and hyponatremia Correct hypoglycemia , hyperkalemia , and metabolic acidosis .[]

  • Neuroleptic Malignant Syndrome

    Laboratory testing revealed metabolic acidosis and increased prothrombin and partial thromboplastin times.[] Agitation, rigidity, elevation in creatine kinase, and leukocytosis were associated findings. NMS was suspected on postoperative day 10.[] , metabolic acidosis, generalized rigidity, rhabdomyolysis, and hyperthermia.[]

  • Addisonian Crisis

    Eventually, they will receive critical VBG results that indicate a mild metabolic acidosis, hyperkalemia, and hyponatremia.[] […] vasoconstrictors Opposition to increases in capillary permeability Inhibition of interleukin-2 (IL-2) production by macrophages Stimulation of polymorphonuclear neutrophil (PMN) leukocytosis[] Pathophysiologically, there is significant hyponatremia and hyperkalemia, often associated with metabolic acidosis, hypoglycemia, and (every so often) hypercalcemia.[]

  • Addison's Disease

    Signs and symptoms include low blood pressure, nausea and vomiting, syncope, hypoglycemia, hyponatremia, hyperkalemia, a metabolic acidosis, lethergy, confusion, and convulsions[] Limited laboratory studies revealed anemia, leukocytosis, and hyponatremia.[] Eosinophilia and lymphocytosis (increased number of eosinophils or lymphocytes, two types of white blood cells) Metabolic acidosis (increased blood acidity), also is due to[]

  • Acute Pancreatitis

    Though the symptoms were rapidly relieved after initiation of treatment, severe hyperglycemia (575 mg/dL), severe metabolic acidosis (pH 6.9), and ketonuria developed at four[] Imaging showed a left-sided pleural effusion and persistent leukocytosis.[] The notion that these might be useful prognostic markers is based partially on the observation that metabolic acidosis (characterized by reduced pH, bicarbonate and base excess[]

  • Disseminated Intravascular Coagulation

    In light of developing fluctuant subgaleal fluid associated with pallor, anemia, metabolic acidosis, and respiratory distress, immediate blood transfusion is warranted.[] By day 10, the patient’s coagulation profile, liver enzymes, and leukocytosis normalized, and renal function significantly improved.[] A comprehensive metabolic panel can help assess renal function, underlying liver synthetic dysfunction, and evaluate for ongoing hemolysis and underlying acidosis.[]

  • Sepsis

    The patient had severe metabolic acidosis with elevated lactate upon arrival to the emergency department.[] […] ascendant and descendant thoracic aortic aneurysm, presenting 7 years after thoracic endovascular aneurysm repair with thoracic pain, fever, inflammatory indexes increase, leukocytosis[] The degree of metabolic acidosis correlated with reduced NETosis (p 0.001), and this was replicated when neutrophils from healthy donors were incubated in acidotic media.[]

  • Renal Infarction

    Metabolic acidosis, hyperkalemia, and hypocalcemia may be encountered.[] The majority of reported cases have presented with laboratory abnormalities, most notably leukocytosis and elevated lactate dehydrogenase (LDH).[] Leukocytosis ( 10 10(9)/L) and elevated lactate dehydrogenase levels ( 620 IU/L) were the most prominent laboratory findings.[]

  • Heat Stroke

    The associated hyperkalemia and metabolic acidosis may lead to an acute renal, cardiac, and hemostatic failure.[] […] as ongoing dehydration occurs ATN causing renal failure atraumatic rhabdomyolysis electrolyte abnormalities: hyperglycaemia, low phosphate, high CK INVESTIGATIONS FBC – leukocytosis[] After several hours, the situation changes from a mixed picture of acidosis and alkalosis to predominant metabolic acidosis because of sustained tissue damage.[]

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