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565 Possible Causes for Leukocytosis, Pediatric Disorder, Splenomegaly

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Sprunt, Frank Alexander Evans (1889-1956): Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis).[whonamedit.com] […] optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder.[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] The 2003 Healthcare Cost and Utilization Project (HCUP) Kids’ Inpatient Database (KID), a robust and widely used measure of pediatric disorders, has estimated that the number[touchoncology.com] Reticulocytosis of 15 to 30% and leukocytosis are common.[merckmanuals.com]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] […] oncologist at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.[theguardian.com] Evaluation Step 0: Leukocytosis ( White Blood Cell Count 11,000/mm3) Confirmed with a second Complete Blood Count with differential No other obvious cause for Leukocytosis[fpnotebook.com]

  • Acute Myelocytic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] Webb, Acute Myeloid Leukemia and Myelodysplastic Disorders, Pediatric Hematology and Oncology, (95-108), (2010).[doi.org] Thus, the bone marrow and peripheral blood are characterized by leukocytosis with a predominance of immature cells, primarily blasts.[ncbi.nlm.nih.gov]

  • Splenic Rupture

    Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to[omicsonline.org] (see differential diagnoses below) References: [3] Diagnostics Laboratory tests : low Hb, leukocytosis, and thrombocytosis ; crossmatch for blood transfusion if needed In[amboss.com] On investigations her haemoglobin was 7.2 g% with thrombocytopenia (platelet count of 42,000 per cu mm) and marked leukocytosis (total leukocyte count of 25,000 per cu mm)[tropicalgastro.com]

  • Acute Lymphoblastic Leukemia

    Splenomegaly and thrombocytopenia were frequently observed more in CD200 patients. Increased frequency of CD34 was associated with CD200 and CD56 patients.[ncbi.nlm.nih.gov] Author information 1 Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, 450 Brookline Avenue, D3-106, Boston, MA, 02450, USA.[ncbi.nlm.nih.gov] , hematological, and immunocytological) parameters pointed towards a diagnosis of Wilms tumor in our case, the subsequent development of thrombocytopenia and lymphocytic leukocytosis[ncbi.nlm.nih.gov]

  • Acute Infectious Lymphocytosis

    .  Splenomegaly is found in 50% of cases and hepatomegaly in approximately 10% of patients.  Rash is present in 20% of cases.  Complications are pneumonitis, meningoencephalitis[slideshare.net] In pediatric ages up to 14 years old, acute infectious lymphocytosis is a clinical disorder, suspected to be of enterovirus-Coxsackie A subgroup that may have upper respiratory[questdiagnostics.com] Leukocytosis Leukocytosis :Significance of Monocytosis vs Lymphocytosis Monocytosis (monocyte count greater than or equal to 10x10 9 ) may indicate : - an underlying malignancy[tcd.ie]

  • Pediatric Chronic Granulomatous Disease

    Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, cytopenias, splenomegaly, and hemophagocytosis by macrophages activated by high cytokine levels.[ncbi.nlm.nih.gov] Seattle Children’s has a long history of successfully caring for children and teens with this and other immune system disorders.[seattlecca.org] […] nitro blue tetrazolium test (almost always positive) Clinically, patients have recurrent lymphadenitis, hepatosplenomegaly, skin rash, pulmonary edema Laboratory Anemia, leukocytosis[pathologyoutlines.com]

  • Sickle Cell Disease

    In two mouse SCD models, Berkeley and SAD, inhibition of red blood cell dehydration and sickling was achieved with correction of hematological parameters, splenomegaly, and[ncbi.nlm.nih.gov] Elder and Jeremie Heath Estepp, Hematologic Disorders of the Eye, The Eye in Pediatric Systemic Disease, 10.1007/978-3-319-18389-3_11, (295-325), (2017).[doi.org] Leukocytosis or erythema does not accompany the swelling.[emedicine.medscape.com]

  • Visceral Larva Migrans

    Follow-up showed increased physical activity, improved respiratory status, and resolution of splenomegaly.[ncbi.nlm.nih.gov] Epidemiology of allergic disorders in early childhood. Pediatr. Pulmonol. Suppl. 16 : 69. 58. 59. Tost, F., A. Hellman, and G. Ockert. 1998 . Toxocara canis infection.[doi.org] Epidemiology of allergic disorders in early childhood. Pediatr. Pulmonol. Suppl. 16 : 69. 58. 59. Tost, F., A. Hellman, and G. Ockert. 1998. Toxocara canis infection.[doi.org]

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