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11 Possible Causes for Leukocytosis, Sensorineural Hearing Loss May Be Presenting Feature

  • Cryopyrin-Associated Periodic Syndrome

    Characteristically Muckle-Wells syndrome is associated with the early development of progressive sensorineural hearing loss.[dermnetnz.org] Diagnostic methods Diagnosis is based on clinical manifestations and on laboratory findings revealing generalized leukocytosis and neurophilia along with others elevated acute[orpha.net] The clinical features of the acute attacks of Muckle-Wells syndrome may include: Fever – not present in all cases, but when present is usually higher than in FCAS (39-40C)[dermnetnz.org]

  • CINCA Syndrome

    The CNS manifestations include chronic aseptic meningitis leading to brain atrophy, mental delay and sensorineural hearing loss.[ncbi.nlm.nih.gov] He also was found to have a mild iron deficiency anemia with a leukocytosis.[healio.com] Laboratory findings reveal slight elevations of inflammatory parameters such as C-reactive protein and erythrocyte sedimentation rate (ESR), together with anemia and leukocytosis[symptoma.com]

  • Muckle-Wells Syndrome

    Characteristically Muckle-Wells syndrome is associated with the early development of progressive sensorineural hearing loss.[dermnetnz.org] Other blood tests could be taken and analyzed as well to see if a patient has leukocytosis (an increase in the number of white cells in the blood), anemia (a deficiency of[raregenomics.org] The clinical features of the acute attacks of Muckle-Wells syndrome may include: Fever – not present in all cases, but when present is usually higher than in FCAS (39-40C)[dermnetnz.org]

  • Familial Spontaneous Pneumothorax

    Mild spondyloepiphyseal dysplasia may also be present, and the hearing loss may be conductive and sensorineural.[nature.com] Antibiotics are often administered if bacterial infection is suspected clinically or because of leukocytosis, neutropenia, or hypoxemia.[aafp.org] The presence of some clinical features—including retinal detachment, cataract, sensorineural hearing loss, early-onset degenerative joint disease, and certain skeletal abnormalities—is[nature.com]

  • Ductus Arteriosus Aneurysm

    Mild spondyloepiphyseal dysplasia may also be present, and the hearing loss may be conductive and sensorineural.[nature.com] The results of laboratory tests were as follows: leukocytosis with a significant shift to the left and normal cerebrospinal fluid. The cerebral tomography was normal.[scielo.br] The presence of some clinical features—including retinal detachment, cataract, sensorineural hearing loss, early-onset degenerative joint disease, and certain skeletal abnormalities—is[nature.com]

  • Pure Autonomic Failure

    The CNS manifestations include chronic aseptic meningitis leading to brain atrophy, mental delay and sensorineural hearing loss.[ojrd.biomedcentral.com] Test Findings Blood tests increased white blood cells ( leukocytosis ) – mild neutrophilia elevated markers of inflammation: erythrocyte sedimentation rate ( ESR ) C-reactive[dermnetnz.org] Chronic polyarthritis and alteration of the growth cartilage also may be present.[ojrd.biomedcentral.com]

  • Citrullinemia

    The CNS manifestations include chronic aseptic meningitis leading to brain atrophy, mental delay and sensorineural hearing loss.[ojrd.biomedcentral.com] Test Findings Blood tests increased white blood cells ( leukocytosis ) – mild neutrophilia elevated markers of inflammation: erythrocyte sedimentation rate ( ESR ) C-reactive[dermnetnz.org] Chronic polyarthritis and alteration of the growth cartilage also may be present.[ojrd.biomedcentral.com]

  • Classic Autosomal Dominant Optic Atrophy

    Twenty per cent develop sensorineural hearing loss; other features are less common. 22. Behr syndrome Inheritance is AR; heterozygotes may have mild features.[slideshare.net] (sensitivity 93.5%, specificity 91%) o Labs: ESR 50 (sensitive but not specific) (ULN: men age/2, women age 10/2), CRP: together 97% sensitivity; anemia, thrombocytosis, leukocytosis[quizlet.com] Presentation is in early childhood with reduced vision. Optic atrophy is diffuse. Prognosis is variable, with moderate to severe visual loss and nystagmus.[slideshare.net]

  • Cataract - Ataxia - Deafness

    Fechtner’s syndrome, which is also reported as a variant of AS, shares with the latter the triad of nephritis, sensorineural hearing loss, and eye abnormalities, and presents[entokey.com] Laboratory studies showed leukocytosis in the upper limits of normal, mildly elevated erythrocyte sedimentation rate, and non-reactive syphilis serologies.[webeye.ophth.uiowa.edu] […] the additional features of macrothrombocytopenia and polymorphonuclear inclusions (called Döhle-like bodies).[entokey.com]

  • Familial Progressive Hyper- and Hypopigmentation

    Mild spondyloepiphyseal dysplasia may also be present, and the hearing loss may be conductive and sensorineural.[nature.com] It is characterized by skin lesions, fever, malaise, and leukocytosis. About 20% of patients have an associated hematopoietic malignancy.[bobbybukamd.com] The presence of some clinical features—including retinal detachment, cataract, sensorineural hearing loss, early-onset degenerative joint disease, and certain skeletal abnormalities—is[nature.com]

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