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1,218 Possible Causes for Leukocytosis, Splenomegaly

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Leukocytosis is a common feature of infectious mononucleosis and absence of this should suggest an alternative diagnosis.[symptoma.com] Pfeiffer‘s glandular fever in lab Significant lab results for infectious mononucleosis are: Absolute und relative leukocytosis ( 4000/ml and 50% of leukocytes) with 10% atypical[lecturio.com]

  • Upper Respiratory Infection

    Approximately half of EBV mononucleosis cases involve generalized adenopathy or splenomegaly. An enlarged liver may also be palpable.[emedicine.medscape.com]

  • Malignant Neoplasm

    Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs). We report a case of colorectal carcinoma as a SMN, following treatment for rhabdomyosarcoma. The patient was[…][ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Fatigue, generalized lymphadenopathy and splenomegaly are its typical features.[symptoma.com] A 60-year-old male patient presented with obvious leukocytosis and progressive weakness.[ncbi.nlm.nih.gov] A baseline F-FDG PET/CT scan in a patient with mantle cell lymphoma showed diffuse minimally FDG-avid lymphadenopathy and splenomegaly.[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    […] in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] During multivariable analysis, leukocytosis 15 109/l, palpable splenomegaly and grade 1 BM reticulin fibrosis remained significant.[ncbi.nlm.nih.gov] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).[ncbi.nlm.nih.gov] Although SI provided a high rate of palliation for patients with symptomatic splenomegaly, the responses were transient.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] The 3 HCL-v patients had leukocytosis and received chemotherapy with variable outcome.[ncbi.nlm.nih.gov] It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly. Lymphadenopathy is usually not seen.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] Her disease was managed during pregnancy using interferon-α alone despite persistent leukocytosis.[ncbi.nlm.nih.gov] One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov]

  • Splenic Infarction

    On admission, he had a low-grade fever and was grossly anaemic; examination revealed splenomegaly.[ncbi.nlm.nih.gov] A post hoc analysis demonstrated that single infarcts were more likely to be associated with fever (20% vs. 63%, p 0.05) and leukocytosis (75% vs. 33%, P 0.06) The clinical[ncbi.nlm.nih.gov] Physical examination on admission revealed a palpable splenomegaly.[ncbi.nlm.nih.gov]

  • Visceral Larva Migrans

    Follow-up showed increased physical activity, improved respiratory status, and resolution of splenomegaly.[ncbi.nlm.nih.gov] Clinical findings were pain, fever, anorexia, dizziness, dyspnea, weight loss, cough, hepatomegaly, splenomegaly and lymphadenopathy.[ijph.tums.ac.ir] A 44-year-old man presented with chills, eruptions, marked leukocytosis (31,400/microlitter), and eosinophilia (eosinophil, 72%).[ncbi.nlm.nih.gov]

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