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850 Possible Causes for Leukocytosis, Splenomegaly

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Sprunt, Frank Alexander Evans (1889-1956): Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis).[whonamedit.com] Pfeiffer‘s glandular fever in lab Significant lab results for infectious mononucleosis are: Absolute und relative leukocytosis ( 4000/ml and 50% of leukocytes) with 10% atypical[lecturio.com]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Reticulocytosis of 15 to 30% and leukocytosis are common.[merckmanuals.com] It also results in leukocytosis and thrombocytosis. On peripheral blood smear, spherocytes are unchanged or may even increase.[medcaretips.com]

  • Primary Myelofibrosis

    Abstract We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Abstract Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).[ncbi.nlm.nih.gov] Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] a Philadelphia (Ph) chromosome without DNA breakpoints in the M-bcr region; (3) the spontaneous loss of detectable Ph-positive cells, 5 years after the first finding of leukocytosis[ncbi.nlm.nih.gov] Leukocytosis is also found in patients with essential thrombocythemia (primary thrombocythemia).[medindia.net]

  • Adult-Onset Still Disease

    […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] […] systemic inflammatory disease which presents with cardinal symptoms of spiking fever, arthralgia, and characteristic non pruritic evanescent salmon pink rash and neutrophilic leukocytosis[ncbi.nlm.nih.gov] Arthritis (OR, 8.6; 95% confidence interval [CI], 1.5-49.1; p 0.014), pharyngitis (OR, 6.9; 95% CI, 1.5-30.2; p 0.010), splenomegaly (OR, 5.4; 95% CI, 1.1-26.7; p 0.039),[ncbi.nlm.nih.gov]

  • Infective Endocarditis

    This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation[ncbi.nlm.nih.gov] CASE PRESENTATION: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis.[ncbi.nlm.nih.gov] Additional findings may include splenomegaly, gallop or arrhythmia, pericardial or pleural rubs, rales, pallor, acute septic monoarticular arthritis or delirium.[symptoma.com]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] During multivariable analysis, leukocytosis 15 10 9 /l, palpable splenomegaly and grade 1 BM reticulin fibrosis remained significant.[ncbi.nlm.nih.gov] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[ncbi.nlm.nih.gov]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] Evaluation Step 0: Leukocytosis ( White Blood Cell Count 11,000/mm3) Confirmed with a second Complete Blood Count with differential No other obvious cause for Leukocytosis[fpnotebook.com] Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly.[icd9data.com]

  • Splenic Infarction

    On admission, he had a low-grade fever and was grossly anaemic; examination revealed splenomegaly.[ncbi.nlm.nih.gov] A post hoc analysis demonstrated that single infarcts were more likely to be associated with fever (20% vs. 63%, p 0.05) and leukocytosis (75% vs. 33%, P 0.06) CONCLUSIONS[ncbi.nlm.nih.gov] Physical examination on admission revealed a palpable splenomegaly.[ncbi.nlm.nih.gov]

  • Splenic Rupture

    Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to[omicsonline.org] (see differential diagnoses below) References: [3] Diagnostics Laboratory tests : low Hb, leukocytosis, and thrombocytosis ; crossmatch for blood transfusion if needed In[amboss.com] On investigations her haemoglobin was 7.2 g% with thrombocytopenia (platelet count of 42,000 per cu mm) and marked leukocytosis (total leukocyte count of 25,000 per cu mm)[tropicalgastro.com]

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