Leukonychia: Causes & Reasons

Possible Causes for Leukonychia

[…] and vesiculopustular variants are rare Nikolski sign may be positive 1/3 of cases are sporadic Healing accompanied by hyperpigmentation, but scarring is rare Longitudinal leukonychia [pathologyoutlines.com]

Patients with Hailey-Hailey disease may also have nail manifestation called ‘longitudinal leukonychia’ which are longitudinal white bands on the fingernails. [aocd.org]

[…] images Images hosted on other servers: Hailey-Hailey in right axilla Hyperpigmented plaques over groin Hailey-Hailey lesions on left groin Figure 2b: Showing longitudinal leukonychia [pathologyoutlines.com]

Alopecia Areata

Red spotted lunulae, onycholysis, and punctate leukonychia were other reported findings. [ncbi.nlm.nih.gov]

Nail examination revealed severe onychodystrophy of all 20 nails, including onycholysis, onychorrhexis and leukonychia (fig. 1 b). [karger.com]

T-cell lymphoma, accompanied by patches of hypopigmentation on the parietotemporal areas of the scalp. b Severe nail deformity, including onycholysis, onychorrhexis and leukonychia [karger.com]

Hepatitis C

Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV). In the majority of cases, hepatitis C follows a mildly symptomatic, chronic course. But because of the risk of progression to cirrhosis and hepatocellular carcinoma, which can both be life-threatening, the timely diagnosis of infection is[…] [symptoma.com]

Thallium Poisoning

Heavy metals pose significant morbidity and mortality threats to humans in connection with both acute and chronic exposure. The often-delayed manifestations of some toxic effects and the wide-spectrum of symptoms caused by heavy metal poisoning may perplex the clinical diagnosis and, when involved in crimes,[…] [ncbi.nlm.nih.gov]

Subungual Fibroma

[…] onychomadesis, onychorrhexis, paronychia Trichinosis Splinter hemorrhages, leukonychia Tuberculosis Leukonychia partialis, yellow nail syndrome Typhoid fever Leukonychia, [musculoskeletalkey.com]

It is associated with lymphoedema, pleural effusion, and (usually) ascites White nail discolouration - leukonychia (images 38-44) Minor trauma - a common cause, and tends [pcds.org.uk]

[…] ulcer with hemorrhage ( K26.0 ) acute gastritis with bleeding ( K29.01 ) ulcerative enterocolitis with rectal bleeding ( K51.01 ) nail L60.8 (subungual) subungual L60.8 Leukonychia [icd10data.com]

Selenosis

Paradise Nut Paradox: Alopecia Due to Selenosis from a Nutritional Therapy Subramanian Senthilkumaran1, Namasivayam Balamurugan2, Rais Vohra3, Ponniah Thirumalaikolundusubramanian4 1 Department of Emergency and Critical Care Medicine, Sri Gokulam Hospitals and Research Institute, Salem, India 2 Neurosciences, Manipal[…] [ijtrichology.com]

Congenital Leukonychia

Some of the more serious variations of leukonychia partialis may lead to leukonychia totalis.[5] Leukonychia striata[edit] Leukonychia striata, transverse leukonychia, or [en.wikipedia.org]

Leukonychia refers to a white discoloration of the nails. [ncbi.nlm.nih.gov]

Unna classified leukonychia based on distribution of whiteness into the following - leukonychia punctata, leukonychia striata, leukonychia totalis and leukonychia partialis [ijdvl.com]

Nail Dystrophy

Muehrcke lines Muehrcke lines are a double band of leukonychia in renal disease. [dermnetnz.org]

It is associated with lymphoedema, pleural effusion, and (usually) ascites White nail discolouration - leukonychia (images 38-44) Minor trauma - a common cause, and tends [pcds.org.uk]

White lines across the nail ( leukonychia striata, or transverse leukonychia) may be Mees' lines or Muehrcke's lines. [en.wikipedia.org]

Hereditary Koilonychia

More Leukonychia Leukonychia striata is one variant of leukonychia, it may be of hereditary, traumatic or systemic origin. [dermatologyoasis.net]

Leukonychia refers to the white discoloration of nail. [idoj.in]

L60.3 Nail dystrophy Or: 2015/16 ICD-10-CM L60.4 Beau's lines Or: 2015/16 ICD-10-CM L60.8 Other nail disorders Applies To Dystrophia unguium Hypertrophy of nail Koilonychia Leukonychia [icd9data.com]

Lowry-Wood Syndrome

Leukonychia can be a true leukonychia involving the nail plate. [e-ijd.org]

@article{Yamamoto1995MultipleED, title={Multiple epiphyseal dysplasia with small head, congenital nystagmus, hypoplasia of corpus callosum, and leukonychia totalis: a variant [semanticscholar.org]

He also had hypoplasia of the corpus callosum and leukonychia totalis, which were not described in the previous cases. [ncbi.nlm.nih.gov]

Onychia

[…] and loss of the nail … Useful english dictionary -onychia — noun combining form ( s) Etymology: New Latin, from onych + ia : condition of the nails of the fingers or toes leukonychia [medicine.academic.ru]

White lines across the nail ( leukonychia striata, or transverse leukonychia) may be Mees' lines or Muehrcke's lines. [en.wikipedia.org]

Small white patches are known as leukonychia punctata. Dark nails are associated with B 12 deficiency. [en.wikipedia.org]

Leukonychia Totalis

Leukonychia can be a true leukonychia involving the nail plate. [e-ijd.org]

[…] white spots or patches under the nails, of unknown cause; the decoloration may be total or in the form of lines (striate or transverse leukonychia) or dots (punctate leukonychia [medical-dictionary.thefreedictionary.com]

Idiopathic acquired true leukonychia totalis. [e-ijd.org]

Hutchinson's Teeth

PMID: 4960377 Hutchinson's incisors in congenital syphilis R A Schwalb. Bull Union Cty Dent Soc. 1967 Feb. No abstract available Similar articles Hutchinson's triad in a 9-year-old girl. Williams J, Kanniappan VK, Manickavasagan T. Williams J, et al. Int J STD AIDS. 1992 Jul-Aug;3(4):295-6. doi: 10.1177/095646249200300415. Int J[…] [pubmed.ncbi.nlm.nih.gov]

Onycholysis

Nails with leukonychia have pale, white marks all over the nail. [sharecare.com]

[…] hands, using detergent-based shampoos or soaps).[5][6][7] Patients with hepatocellular dysfunction may develop hair-thinning or hair loss and nail changes such as clubbing, leukonychia [en.wikipedia.org]

Anonychia Congenita Totalis

Leukonychia punctata Also known as "true" leukonychia, this is the most common form of leukonychia, in which small white spots appear on the nails. [en.academic.ru]

[…] shows (a) melanonychia, (b) onycholysis, (c) paronychia with onychodystrophy, (d) leukonychia, (e) blue chromonychia, (f) onychomadesis Click here to view True leukonychia [tjmrjournal.org]

Punctate Leukonychia Children usually are affected by true leukonychia that occurs due to trauma to the distal matrix. [karger.com]

Pili Torti

A patient with both pili torti and leukonychia had a family history indicating dominant inheritance for the nail changes. However, no relatives had hair abnormalities. [ncbi.nlm.nih.gov]

( White Nails,) Ectrodactyly ectodermal Dysplasia cleft Syndrome (30 %) ( Eec Syndrome, Split Hand split Foot ectodermal Dysplasia cleft Syndrome,) White Nails (30 %) ( Leukonychia [gulfdoctor.net]

Acta Dermato-Venereologica 53(5): 385-392, 1973 Association of pili torti and leukonychia. Cutis 35(6): 533-534, 1985 [eurekamag.com]

Trachonychia

International Classification of Diseases, Tenth Revision, Clinical Modification.L60.3 Nail dystrophy and Trachonychia L60.1 Photoonycholysis (disorder) L60.8 Acquired striate leukonychia [averbis.com]

[…] secondary infection Common secondary infection of repeat picking of paronychia associated with OCD and LSC Trachonychia (Rough nails) Can be see with psoriasis Punctate leukonychia [quizlet.com]

Congenital Onychodysplasia

Convert to ICD-10-CM : 757.5 converts approximately to: 2015/16 ICD-10-CM Q84.3 Anonychia Or: 2015/16 ICD-10-CM Q84.4 Congenital leukonychia Or: 2015/16 ICD-10-CM Q84.5 Enlarged [icd9data.com]

* i.e. goes away w pressure multiple transverse leukonychia bands parallel to lunula in the setting of hypoalbuminemia (liver disease, nephrotic syndrome, malnutrition) partial [quizlet.com]

(Fig 5-7) Leukonychia totalis, multiple sebaceous cysts and renal calculi9 Hereditary leukonychia associated with duodenal ulcer and gallstones10 Keratitis, ichthyosis, and [sites.google.com]

Peeling Skin Syndrome Type 1

Entry H00737 Disease Name Peeling skin syndrome Subgroup Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) Description Peeling skin [genome.jp]

Green Green List (high evidence) CAST 2 reviews 1 green BIALLELIC, autosomal or pseudoautosomal Sources Expert Review Green Research Phenotypes Peeling skin with leukonychia [panelapp.genomicsengland.co.uk]

McLean WH, Wang H, Feng C, Duo L, Zhou EY, Ren Y, Dai L, Chen Y, Zhang J, Xu X, O'Toole EA, Kelsell DP, Yang Y Title Loss-of-function mutations in CAST cause peeling skin, leukonychia [genome.jp]

Other keratitis

DFNB-1A, Hystrix-like ichthyosis with deafness, keratitis-ichthyosis-deafness syndrome, autosomal dominant, keratoderma palmoplantar, deafness, Knuckle pads, deafness AND leukonychia [databases.lovd.nl]

[…] syndrome; Deafness, autosomal dominant 3a 2 0 0 0 0 0 2 Knuckle pads, deafness AND leukonychia syndrome 2 0 0 0 0 0 2 Nonsyndromic Deafness 0 0 2 0 0 0 2 Progressive sensorineural [clinvarminer.genetics.utah.edu]

BPS is an autosomal dominant disorder characterized by sensorineural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, It shows considerable phenotypic [abcam.com]

Tricho-Retino-Dento-Digital Syndrome

ORPHA:1028 Heimler Syndrome 1 Enamel hypoplasia, Leukonychia, Amelogenesis imperfecta OMIM:234580 Heimler Syndrome 2 Dental crowding, Beau's lines, Leukonychia, Amelogenesis [mousephenotype.org]

[…] totalis Leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome Limb-mammary syndrome Limited cutaneous systemic sclerosis Limited systemic sclerosis [se-atlas.de]

[…] associated with multiple organ system abnormalities Isologous chimera Johanson-Blizzard syndrome Kenny syndrome Klippel-Trenaunay-Weber syndrome Knuckle pads, deafness AND leukonychia [emedcodes.com]

Peeling Skin Syndrome

Entry H00737 Disease Name Peeling skin syndrome Subgroup Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) Description Peeling skin [genome.jp]

Peeling skin in association with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK). [rarediseases.org]

Congenital Alopecia

[…] totalis syndrome. ( 26370416 ) Wang H....Yang Y. 2015 2 Exome sequencing reveals mutation in GJA1 as a cause of keratoderma-hypotrichosis-leukonychia totalis syndrome. [malacards.org]

Acronym PPKCA1 Synonyms Keratoderma-hypotrichosis-leukonychia totalis syndrome PPKCA, Stevanovic type Keywords Disclaimer Any medical or genetic information present in this [uniprot.org]

[…] of the digits, and pseudoainhum formation. (104100) MalaCards based summary : Palmoplantar Keratoderma and Congenital Alopecia 1, also known as keratoderma-hypotrichosis-leukonychia [malacards.org]

Peeling Skin Syndrome Type 3

Peeling skin in association with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK). [rarediseases.org]

acral punctate keratoses, cheilitis, and knuckle pads, 616295 OMIM:#616295 Peeling skin HP:0040189 Leukonychia HP:0001820 Punctate palmoplantar hyperkeratosis HP:0007530 [panelapp.genomicsengland.co.uk]

Knuckle Pads

knuckle pads, and leukonychia, It shows considerable phenotypic variability. [malacards.org]

Definition An autosomal dominant disorder characterized by sensorineural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, It shows considerable phenotypic [uniprot.org]

447562003~MAPGROUP~3 900000000000497000~MAPTARGET~N2371 900000000000509007~ACCEPTABILITYID~900000000000548007 447562003~MAPRULE~IFA 1271009 | Knuckle pads, deafness AND leukonychia [bioportal.bioontology.org]

Gorlin-Bushkell-Jensen Syndrome

Fig. 1 Trauma-induced punctate true leukonychia Pseudo-leukonychia also often presents as punctate leukonychia. [springermedizin.de]

Leukonychia striae. Arch Dermatol. 1976;112(8):1147. Article CAS Google Scholar Howard SR, Siegfried EC. A case of leukonychia. [link.springer.com]

References: Bushkell LL. et al "Leukonychia totalis, multiple sebaceous cysts, and renal calculi. [wellnessadvocate.com]

Basaran-Yilmaz Syndrome

Dyskératose Homme Hyperkératose Maladie congénitale Ongle pathologie Peau pathologie Keyword (en) Adult Concomitant disease Child Case study Family study Hypotrichosis Keratoderma Leukonychia [pascal-francis.inist.fr]

A disease characterized by keratoderma, hypotrichosis, and leukonychia totalis. Keratoderma Hypotrichosis Leukonychia Syndrome. [accessanesthesiology.mhmedical.com]

The family presented with congenital hypotrichosis, dry skin, keratosis pilaris, and leukonychia totalis. [accessanesthesiology.mhmedical.com]

Amelogenesis Imperfecta Hypoplastic Type

Focal dermal hypoplasia Other names Goltz syndrome This condition is inherited in an X-linked dominant manner. Specialty Medical genetics Focal dermal hypoplasia is a form of ectodermal dysplasia.[1] It is a multisystem disorder characterized primarily by skin manifestations to the atrophic and hypoplastic areas of skin[…] [en.wikipedia.org]

Bart-Pumphrey Syndrome

Bart RS, Pumphrey RE (1967) Knuckle pads, leukonychia and deafness. [altmeyers.org]

Case 2 defined that he had hearing loss, leukonychia and knuckle pads [Table - 1]. [ijdvl.com]

Leukonychia may improve with age. [jamanetwork.com]

FLOTCH Syndrome

Sporadic congenital leukonychia with koilonychia. Int J Dermatol 2012; 51: 1400–1402. 7. Baran R, Martinon J. Association of total leukonychia and koilonychia. [medicaljournals.se]

Cited by Leukonychia: What Can White Nails Tell Us? Iorizzo M, Starace M, Pasch MC. Iorizzo M, et al. [pubmed.ncbi.nlm.nih.gov]

111202002 Congenital leukonychia 47139007 Leukonychia totalis 763792009 FLOTCH syndrome 774065001 SNOMED CT Concept 138875005 Clinical finding 404684003 Disease 64572001 [findacode.com]