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798 Possible Causes for Leukopenia, Lymphadenopathy, Pancytopenia

  • Primary Myelofibrosis

    Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia[ncbi.nlm.nih.gov] Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[ncbi.nlm.nih.gov] Based on these findings, we diagnosed the patient with systemic lymphadenopathy due to HCL.[ncbi.nlm.nih.gov] Hairy cell leukemia typically presents with pancytopenia and often mimics aplastic anemia.[ncbi.nlm.nih.gov]

  • B-Precursor Acute Lymphoblastic Leukemia

    She displayed hepatosplenomegaly and pleural and abdominal effusions without lymphadenopathy. Lactate dehydrogenase (10,554 U/L; normal range 106–211 U/L) was elevated.[journals.lww.com] We present the case of a 9-year-old girl from northwestern Greece admitted to our Hospital because of malaise, low-grade fever, intermittent hip joint pain, anemia, leukopenia[ncbi.nlm.nih.gov] B-precursor acute lymphoblastic leukemia is diagnosed with a standard complete blood count (CBC), which will reveal pancytopenia.[symptoma.com]

  • Hypersplenism

    Unfortunately, these patients may become intolerant to this therapy when it is complicated by hypersplenism with leukopenia and/or thrombocytopenia.[ncbi.nlm.nih.gov] Always remember to check for any accompanying lymphadenopathy and/or features of liver disease. Investigations Liver biopsy. Bone marrow biopsy. Lymph node biopsy.[patient.info] Pancytopenia can be limited by reducing the volume of the functional spleen.[ncbi.nlm.nih.gov]

  • Malignant Histiocytosis

    Two years later, he manifested persistent fever, leukopenia, effusions and hypoproteinemia, and his general condition worsened progressively.[ncbi.nlm.nih.gov] Four months after the operation, skin induration on the neck and anterior thoracic wall and systemic lymphadenopathy were noted.[ncbi.nlm.nih.gov] […] pancreas at initial presentation is exceptional, this entity should be included in the differential diagnosis of acute pancreatitis, especially when hepatosplenomegaly and pancytopenia[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    Blood counts generally reveal normocytic, normochromic anemia, leukopenia, and thrombocytopenia.[symptoma.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Thus, patients suffering from myelofibrosis eventually develop anemia, leukopenia, and thrombocytopenia.[symptoma.com]

  • Brucellosis

    Leukopenias associated with thrombocytopenia were observed. BMA showed to be normal.[ncbi.nlm.nih.gov] Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] Pancytopenia improved with treatment of brucellosis on all patients.[ncbi.nlm.nih.gov]

  • Aggressive Systemic Mastocytosis

    In fact, bone marrow failure is associated with cytopenias and patients suffering from anemia, leukopenia, or thrombocytopenia may present with pallor, weakness, and fatigue[symptoma.com] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[orpha.net]

  • T-cell Acute Lymphoblastic Leukemia

    In comparison, patients 16 to 60 years old (n 21) more commonly had an anterior mediastinal mass (8 [38%]), hepatosplenomegaly (10 [48%]), and lymphadenopathy (16 [76%]).[academic.oup.com] The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection.[ncbi.nlm.nih.gov] Complete blood count revealed pancytopenia with abnormal lymphoid cells.[ncbi.nlm.nih.gov]

  • Multicentric Castleman's Disease

    Case report In 1994, a 19 years old girl presented with a non-erosive bilateral arthritis of hands and wrists, leukopenia and hypocomplementemia.[zdoc.site] ORPHA:93686 Synonym(s): MCD Multicentric giant lymph node hyperplasia Prevalence: - Inheritance: - Age of onset: - ICD-10: D36.0 OMIM: 148000 UMLS: C1334815 MeSH: C537372[orpha.net] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov]

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