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341 Possible Causes for Leukopenia, Macrocytic Anemia

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] Leukopenia, thrombocytopenia, arterial and venous thromboses, and episodic crises are common. Diagnosis requires flow cytometry.[merckmanuals.com] […] tur·nal he·mo·glo·bi·nu·ri·a an infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia[medical-dictionary.thefreedictionary.com]

  • Myelodysplasia

    Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy.[ncbi.nlm.nih.gov] Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Can present with symptoms of anaemia, leukopenia, and thrombocytopenia, but often found during routine laboratory investigations in asymptomatic patients.[bestpractice.bmj.com]

  • Pernicious Anemia

    Macrocytic anemia incidiously appeared in September 1999.[ncbi.nlm.nih.gov] A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com] Intravenous Lipid Emulsion-Associated Catatonia, Thrombocytopenia, and Leukopenia: A Case Report and the Role of NMDA Receptor .[bjp.rcpsych.org]

  • Folate-Deficiency Anemia

    Definition / general Folate deficiency is a low level of folic acid (Vitamin B9) in the body Essential features Characterized by macrocytic anemia Terminology Also called[pathologyoutlines.com] The disease also is characterized by leukopenia (a deficiency of white blood cells, or leukocytes ), by thrombocytopenia (a deficiency of platelets ), by ineffective blood[britannica.com] If severe, there may be leukopenia and thrombocytopenia. There is no clear consensus on the level of serum folate that indicates deficiency.[patient.info]

  • Promyelocytic Leukemia

    In addition, microgranular APL often presents with an elevated or normal white blood cell count in contrast with the leukopenia seen in traditional APL.[ncbi.nlm.nih.gov] The peripheral smear showed normochromic, macrocytic anemia (Hgb 9.2 g/dL, MCHC 32.8%, MCV 117 fL) and leukopenia (white blood cells [WBC] 3200/mL).[gotoper.com] An 84-year-old man presented with leukopenia (2.2 10(9)/L) and anemia (Hb 12.5 g/dL).[ncbi.nlm.nih.gov]

  • Myxedema

    Mild leukopenia and a normocytic anemia are also frequently present.[aafp.org] These include macrocytic anemia and high creatine kinase and cholesterol levels.[cureus.com] […] secondary to hemorrhage, or macrocytic anemia caused by vitamin B12 deficiency, or normocytic normochromic anemia, which may be secondary to decreased oxygen requirement[emedicine.medscape.com]

  • Azathioprine

    However, leukopenia, the most common toxicity, still restricts its clinical applications.[ncbi.nlm.nih.gov] […] including macrocytic anemia, and/or pancytopenia may occur; severe bone marrow suppression may also occur; patients with intermediate thiopurine S-methyl transferase (TPMT[reference.medscape.com] Macrocytic anemia — Anemia where blood cells are much larger than normal. Myelosuppression — Decrease in the proliferation of bone marrow cells.[encyclopedia.com]

  • Folic Acid Deficiency

    The disease also is characterized by leukopenia (a deficiency of white blood cells, or leukocytes ), by thrombocytopenia (a deficiency of platelets ), by ineffective blood[britannica.com] Folic acid deficiency (FAD) may result in macrocytic anemia.[ncbi.nlm.nih.gov] If severe, there may be leukopenia and thrombocytopenia. There is no clear consensus on the level of serum folate that indicates deficiency.[patient.info]

  • Primary Myelofibrosis

    We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia[ncbi.nlm.nih.gov] Compared with pre-PMF, overt PMF was enriched in patients with anemia, thrombocytopenia, leukopenia, higher blast count, symptoms, large splenomegaly, and unfavorable karyotype[ncbi.nlm.nih.gov] May be anaemia and leukopenia. Thrombocytosis is more common than thrombocytopenia.[patient.info]

  • Hereditary Orotic Aciduria

    ·du·ri·a ( ōr-ot'ik as'i-dyu'rē-ă ), [MIM*258900] A rare disorder of pyrimidine metabolism characterized by hypochromic anemia with megaloblastic changes in bone marrow, leukopenia[medical-dictionary.thefreedictionary.com] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com] Hereditary orotic aciduria was found in a 7-year-old girl who had anemia, leukopenia, a megaloblastic bone marrow, crystalluria, and normal growth and intelligence.[jamanetwork.com]

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