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210 Possible Causes for Leukopenia, Macrocytosis

  • Pernicious Anemia

    A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com] BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) 100 fL.[ncbi.nlm.nih.gov] This impaired DNA synthesis also causes an abnormal decrease in white blood cells, called leukopenia , with odd-looking shapes in their nuclei.[study.com]

  • Folate-Deficiency Anemia

    A blood smear will show macrocytes, hypersegmented polymorphs, leukopenia, and thrombocytopenia if the deficiency is severe enough.[symptoma.com] Both subjects were African American women with markedly elevated C-reactive protein concentrations, macrocytosis, and normal serum cobalamin concentrations; only one subject[ncbi.nlm.nih.gov] The disease also is characterized by leukopenia (a deficiency of white blood cells, or leukocytes ), by thrombocytopenia (a deficiency of platelets ), by ineffective blood[britannica.com]

  • Severe Aplastic Anemia

    Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[msdmanuals.com] Mild anemia and macrocytosis may indicate SAA in patients otherwise possibly diagnosed with immune thrombocytopenic purpura.[symptoma.com] […] cell count (anemia) can cause: Fatigue Pallor (paleness) Rapid heart rate Shortness of breath with exercise Weakness Lightheadedness upon standing Low white cell count (leukopenia[mountsinai.org]

  • Anemia

    […] features the best content from AFP , as identified by the AFP editors, on anemia and related issues, including blood transfusions, iron deficiency and iron supplementation, macrocytosis[aafp.org] There may be leukopenia and/or and thrombocytopenia, but these features do not represent a diagnostic requirement.[atlasgeneticsoncology.org] Macrocytic anemia Macrocytosis is observed frequently using blood cell analyzers (Figure 3 ).[dx.doi.org]

  • Vitamin B12 Deficiency

    He had a severe hypoproliferative megaloblastic anemia with hemolysis (hemoglobin 61g/L, mean corpuscular volume 99fL, reticulocytes 0.8%, haptoglobin undetectable), leukopenia[ncbi.nlm.nih.gov] We report a case of a 46-year-old Moroccan man presenting with severe hemolytic anemia, thrombocytopenia, and renal failure in absence of macrocytosis, thus mimicking a genuine[ncbi.nlm.nih.gov] Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Leukopenia and Thrombocytopenia due to direct bone marrow effect, but also from cirrhosis/splenomegaly.[errolozdalga.com] Alcohol is a common cause of macrocytosis, with a mean corpuscular volume (MCV) of 100-110 fL seen in a majority of patients.[symptoma.com] […] enzyme levels Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels elevated, usually 300 U/L; AST/ALT ratio 2:1 Hematologic Anemia Leukocytosis or leukopenia[clevelandclinicmeded.com]

  • Acute Alcohol Intoxication

    Folate supplements may also be required and those with macrocytosis on their Full Blood Count should have their folate status checked.[stewartnutrition.co.uk]

  • Aplastic Anemia

    Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[merckmanuals.com] Anemia is accompanied by reticulocytopenia, and macrocytosis is a common feature. The RBCs should not present relevant anisocytosis and poikilocytosis.[nature.com] The regimen has a low incidence of bone marrow suppression, and the incidences of anemia, leukopenia, neutropenia and thrombocytopenia exceeding grade 3 are less than 5%.[ncbi.nlm.nih.gov]

  • Iron Deficiency Anemia

    A vitamin B12 deficiency due to pernicious anemia (positive intrinsic factor antibodies) was also highlighted, but this was not enough to explain the anemia without macrocytosis[ncbi.nlm.nih.gov]

  • Azathioprine

    Urology, Shiga University of Medical Science, Seta, Otsu, Shiga 520‐2121, Japan Search for more papers by this author First published: 01 July 2007 Cited by: 10 Abstract Macrocytosis[doi.org] However, leukopenia, the most common toxicity, still restricts its clinical applications.[ncbi.nlm.nih.gov] Megabloblastic erythropoeisis or macrocytosis (production of large red blood cells).[dermnetnz.org]

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