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278 Possible Causes for Leukopenia, Macrocytosis

  • Azathioprine

    However, leukopenia, the most common toxicity, still restricts its clinical applications.[ncbi.nlm.nih.gov] Megabloblastic erythropoeisis or macrocytosis (production of large red blood cells).[dermnetnz.org] TPMT genotype and tertiles of TPMT activity were compared to relapse free survival and occurrence of adverse events, particularly leukopenia.[ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    The disease also is characterized by leukopenia (a deficiency of white blood cells, or leukocytes ), by thrombocytopenia (a deficiency of platelets ), by ineffective blood[britannica.com] Both subjects were African American women with markedly elevated C-reactive protein concentrations, macrocytosis, and normal serum cobalamin concentrations; only one subject[ncbi.nlm.nih.gov] If severe, there may be leukopenia and thrombocytopenia. There is no clear consensus on the level of serum folate that indicates deficiency.[patient.info]

  • Pernicious Anemia

    A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com] Macrocytosis is defined as having the mean corpuscular volume (MCV) 100 fL.[ncbi.nlm.nih.gov] Intravenous Lipid Emulsion-Associated Catatonia, Thrombocytopenia, and Leukopenia: A Case Report and the Role of NMDA Receptor .[bjp.rcpsych.org]

  • Cytarabine

    Anemia, leukopenia, and thrombocytopenia may occur.[pdr.net] . : The Macrocytosis of Hepatic Disease. II. Thick Macrocytosis - Blood 15 , 244, 1960. PubMed Google Scholar 3). Borek B.[link.springer.com] Adverse Reactions: Myelosuppression (leukopenia, thrombocytopenia, anemia), GI upset, anorexia, abdominal pain, oral ulceration, rash, fever, hepatic dysfunction, infection[empr.com]

  • Mercaptopurine

    For this study, Cox proportional hazard ratios (HRs) were calculated to compare AZA and MP for discontinuation rates within 5 months, incidence of hepatotoxicity, leukopenia[ncbi.nlm.nih.gov] Megabloblastic erythropoeisis or macrocytosis (production of large red blood cells).[dermnetnz.org] […] reported on an inherited nucleoside diphosphate-linked moiety X motif 15 (NUDT15) c.415C T low-function variant that is associated with decreased thiopurine metabolism and leukopenia[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy.[ncbi.nlm.nih.gov] A 41-year-old patient manifested pancytopenia with macrocytosis following pesticide exposure. She was later found to have myelodysplasia with trisomy 15.[ncbi.nlm.nih.gov] Can present with symptoms of anaemia, leukopenia, and thrombocytopenia, but often found during routine laboratory investigations in asymptomatic patients.[bestpractice.bmj.com]

  • Nitrous Oxide

    We present a case of non-immune haemolytic anaemia with leukopenia and acute severe neurological impairments, as a result of severe vitamin B12 deficiency due to recreational[ncbi.nlm.nih.gov] Significant investigation results included a low serum vitamin B12 concentration, mild macrocytosis and raised serum homocysteine concentration.[ncbi.nlm.nih.gov] Moderate macrocytosis, low serum B12 levels, and a positive Schilling test result led to the diagnosis of pernicious anemia.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] FBC will show varying degrees of anaemia, usually of a normochromic, normocytic picture, although high cell turnover can produce folate deficiency and a picture of macrocytosis[patient.info] Leukopenia, thrombocytopenia, arterial and venous thromboses, and episodic crises are common. Diagnosis requires flow cytometry.[merckmanuals.com]

  • Hydroxyurea

    Therapy was discontinued in 3 patients due to leukopenia that recovered on discontinuation of hydroxyurea.[ijdvl.com] […] treatment: Leucopaenia (reduced white cell count) Anaemia (reduced red cell count) Thrombocytopenia (reduced platelet count) Pancytopaenia (reduction in all blood cell types) Macrocytosis[dermnetnz.org] The macrocytosis which occurs in almost all patients on hydroxyurea may contribute as these macrocytes circulate poorly through the capillary network.[omicsonline.org]

  • Hereditary Orotic Aciduria

    ·du·ri·a ( ōr-ot'ik as'i-dyu'rē-ă ), [MIM*258900] A rare disorder of pyrimidine metabolism characterized by hypochromic anemia with megaloblastic changes in bone marrow, leukopenia[medical-dictionary.thefreedictionary.com] Macrocytosis is a common finding in clinical settings .[enotes.tripod.com] Hereditary orotic aciduria was found in a 7-year-old girl who had anemia, leukopenia, a megaloblastic bone marrow, crystalluria, and normal growth and intelligence.[jamanetwork.com]

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