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746 Possible Causes for Leukopenia, Splenomegaly

  • Infectious Mononucleosis

    Leukopenia and thrombocytopenia are not uncommon.[ncbi.nlm.nih.gov] Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia[ncbi.nlm.nih.gov] Abstract We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Compared with pre-PMF, overt PMF was enriched in patients with anemia, thrombocytopenia, leukopenia, higher blast count, symptoms, large splenomegaly, and unfavorable karyotype[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com] Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] This impaired DNA synthesis also causes an abnormal decrease in white blood cells, called leukopenia , with odd-looking shapes in their nuclei.[study.com]

  • Myelodysplasia

    Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy.[ncbi.nlm.nih.gov] Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Non-reportable disorder s include: Anemia, leukopenia and thrombocytopenia.[seer.cancer.gov]

  • Systemic Lupus Erythematosus

    Drugs causing leukopenia Some drugs may lead to leukopenia.[news-medical.net] […] relapsing illness, with a variety of different presentations. [ 5 , 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[patient.info] […] relapsing illness, with a variety of different presentations. [ 5, 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[patient.info]

  • Gaucher Disease

    Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia.[en.wikipedia.org] CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] Splenectomy may be helpful for patients with anemia, leukopenia, or thrombocytopenia or when spleen size causes discomfort.[merckmanuals.com]

  • Felty's Syndrome

    Jump to navigation Jump to search syndrome that results in rheumatoid arthritis, splenomegaly and neutropenia Felty syndrome Rheumatoid arthritis with splenoadenomegaly and leukopenia[wikidata.org] Computed tomography of the pelvis led to an incorrect diagnosis of malignancy, while radionuclide imaging using Tc-99m sulfur colloid confirmed the diagnosis of ectopic splenomegaly[ncbi.nlm.nih.gov] Abstract The syndrome of atrophic polyarthritis occurring in an adult, associated with fever, secondary anemia, leukopenia and splenomegaly, was described by Felty 1 in 1924[annals.org]

  • Post-Polycythemia Vera Myelofibrosis

    Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[duo.uio.no] KEYWORDS: myelofibrosis; ruxolitinib; splenomegaly; tumor lysis syndrome[ncbi.nlm.nih.gov] May be anaemia and leukopenia. Thrombocytosis is more common than thrombocytopenia.[patient.info]

  • Follicular Lymphoma

    Splenic infiltration of lymphoma cells may cause splenomegaly in many cases.[ncbi.nlm.nih.gov] […] develops any systemic symptoms.Another set of symptoms which may occur in the later stages of the condition are those depicting dysfunction of the bone marrow such as anemia, leukopenia[symptoma.com] […] year-old man, in clinical remission 17 years after radiation therapy for a localized low-grade follicular lymphoma (FL), developed extensive lymphadenopathy, ascites, and splenomegaly[ncbi.nlm.nih.gov]

  • Sjogren's Syndrome

    Blood tests may reveal elevated erythrocyte sedimentation rate and transaminase levels, anemia, leukopenia, eosinophilia, hypergammaglobulinemia, presence of antinuclear antibodies[symptoma.com] On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly.[ncbi.nlm.nih.gov] High SP-D levels were found with severe glandular involvement, hypergammaglobulinemia, leukopenia, extraglandular manifestations, and positive anti-Ro/La antibodies.[sclero.org]

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