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1,168 Possible Causes for Leukopenia, Splenomegaly

  • Infectious Mononucleosis

    Leukopenia and thrombocytopenia are not uncommon.[ncbi.nlm.nih.gov] Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov]

  • Hypersplenism

    While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] Unfortunately, these patients may become intolerant to this therapy when it is complicated by hypersplenism with leukopenia and/or thrombocytopenia.[ncbi.nlm.nih.gov] A big spleen can cause anaemia, thrombocytopenia and/or leukopenia just by being that massive.[medicguide.blogspot.com]

  • Felty's Syndrome

    […] of other known causes of leukopenia.[ncbi.nlm.nih.gov] Computed tomography of the pelvis led to an incorrect diagnosis of malignancy, while radionuclide imaging using Tc-99m sulfur colloid confirmed the diagnosis of ectopic splenomegaly[ncbi.nlm.nih.gov] Abstract The syndrome of atrophic polyarthritis occurring in an adult, associated with fever, secondary anemia, leukopenia and splenomegaly, was described by Felty 1 in 1924[annals.org]

  • Primary Myelofibrosis

    We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Compared with pre-PMF, overt PMF was enriched in patients with anemia, thrombocytopenia, leukopenia, higher blast count, symptoms, large splenomegaly, and unfavorable karyotype[ncbi.nlm.nih.gov]

  • Ehrlichiosis

    I report a case of tick-borne ehrlichiosis in which the primary presentation suggested an infectious diarrhea, with impressive leukopenia and thrombocytopenia.[ncbi.nlm.nih.gov] Splenomegaly, a characteristic feature of E. muris infection, was associated with an expanded and disorganized marginal zone and a nearly 66-fold increase in the level of[ncbi.nlm.nih.gov] Abdomen: Enlargement of the abdomen may be evident with splenomegaly. The rapid cycling of white blood cells and lymph will lead to the enlargement of the spleen.[symptoma.com]

  • T-Cell Lymphoma

    Grade 3/4 leukopenia occurred in 43 (23.4%) patients. Major non-hematological toxicities included nausea (n 117, 63.6%) and vomiting (n 66, 35.9%).[ncbi.nlm.nih.gov] Splenomegaly and adenopathy in mesentery, retro peritoneum and lymph node chains in the limbs were observed.[ncbi.nlm.nih.gov] Grades 3/4 adverse events (AEs) included hypophosphademia in 4 patients, leukopenia in 5, neutropenia in 9, and lymphopenia in 18 patients.[onclive.com]

  • Malignant Histiocytosis

    Two years later, he manifested persistent fever, leukopenia, effusions and hypoproteinemia, and his general condition worsened progressively.[ncbi.nlm.nih.gov] The long duration of massive splenomegaly suggests that this patient could represent a chronic form of MH.[ncbi.nlm.nih.gov] Anemia, thrombocytopenia, and leukopenia are frequent.[symptoma.com]

  • Hairy Cell Leukemia

    Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[ncbi.nlm.nih.gov] Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] The HCL patients had a significantly higher frequency of leukopenia (p 0.024) and monocytopenia (p 0.008) and a lower frequency of leukocytosis (p 0.018) than HCL-v patients[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] Leukopenia, thrombocytopenia, arterial and venous thromboses, and episodic crises are common. Diagnosis requires flow cytometry.[merckmanuals.com]

  • Chronic Myelomonocytic Leukemia

    Not having enough normal white blood cells (leukopenia) can lead to frequent or severe infections .[cancer.org] Splenomegaly is frequently seen and may be massive.[ncbi.nlm.nih.gov] The immune system's inability to guard against infection effectively because of a lack of neutrophils (a type of white cell), a condition called leukopenia.[lls.org]

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