Leukostasis is a medical emergency that calls for immediate intervention. … Patients with markedly elevated WBC counts ( 100,000 cells/µL) can present with symptoms of leukostasis (ie, respiratory distress and altered mental status). … In the case of hyperleukocytosis (>100 x 109/l), symptoms of leukostasis may manifest.
Leukostasis in AML Thornton, KA, Levis, M. … FLT3 Mutation and Acute Myelogenous Leukemia with Leukostasis. … LeukostasisLeukostasis – predominantly in those with WBC counts 100,000 (10% of patients); can also be seen in patients with WBC 50,000 Most common in those with M4 or M5
Although patients may present with symptoms of leukostasis (eg, respiratory distress, altered mental status) because of the presence of large numbers of lymphoblasts in the … peripheral circulation, leukostasis is much less common in people with ALL than those with acute myelogenous leukemia (AML), and it occurs only in patients with the highest
bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to gouty arthritis that is secondary to hyperuricemia Priapism, tinnitus, or stupor from leukostasis … tissue death) of the arms and legs Painful swollen joints, caused by gouty arthritis , which is in turn caused by hyperuricemia Bone pain Priapism Tinnitus Stupor due to leukostasis … Further signs such as tinnitus, priapism, and stupor are suggestive of leukostasis.
cytokine release à capillary leak Treatment: dexamethasone (without treatment, mortality 30%) Role of prophylactic steroids prior to ATRA induction unclear Hyperleukocytosis/leukostasis … Hyperleucocytosis • Marked increase in WBC count due to the rapid maturation induced by ATRA of a large mass of leukemic cells, may result in leukostasis. • Most current remission … The marked increase in WBC count due to the rapid maturation induced by ATRA of a large mass of leukemic cells, may result in leukostasis and management is controversial.