In the case of hyperleukocytosis (>100 x 109/l), symptoms of leukostasis may manifest.
Rarely, the aforementioned hematological disturbances manifest in dyspnea, transient ischemic attacks, or cerebrovascular accidents (related to leukostasis), gastrointestinal
Acute lymphocytic leukemia (ALL) is a type of cancer that affects the bone marrow, and, subsequently, the blood. It can occur at any age, but children are most commonly affected by it. The bone marrow is a vital organ, that is responsible for the production and maturation of all of the cellular components of the…
Promyelocytic leukemia (PL) is a hematopoietic malignancy, caused by a genetic mutation in the myeloid cells. It constitutes 5 to 10% of adult leukemias and is frequently a type of cancer with a rapid progression. The mutation involves a translocation that leads to the fusion of two genes, mostly the retinoic acid…
Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is the most common myeloproliferative disorder. The diagnosis of chronic myeloid leukemia is based on the following: Histologic findings in the peripheral blood Philadelphia (Ph) chromosome in bone marrow cells The workup for chronic myeloid…
Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia. In order to fulfill World Health Organization (WHO) criteria for AML-5, a patient must have greater than 20% blasts in the bone marrow, and of these, greater than 80% must be of the monocytic lineage. A further…
Symptoms of leukemia vary with the type. The common symptoms of the disease include the following: Undue weight loss Constant felling of tiredness and fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily…