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6 Possible Causes for Levels of Naive T Cells Decreased

  • Multiple Sclerosis

    Blood T cell levels decrease when S1P receptors are activated, as naive T cells are sequestered within secondary lymphoid organs after their egress from peripheral blood [[] S1P is an extracellular signaling molecule that regulates trafficking of many types of T and B cells from the lymph nodes to the blood (Table 2 ) [ 58 ].[]

  • Cytomegalovirus

    […] and old individuals had similar levels of naive T cells in the periphery ( p 0.44; Fig. 3 A , white squares).[] In marked contrast, in familial longevity, the frequency of naive CD8 T cells was not decreased by CMV infection ( Fig. 1 A , squares).[] However, this highly significant age-associated decrease in the frequency of naive T cells seen in the general population was absent in CMV-seropositive offspring, where middle-aged[]

  • Autosomal Dominant Hyper-IgE Syndrome

    Elevated serum IgE level with CD3 , CD4 , naive CD8 T cell Lymphopenia Normal total B lymphocyte percentage but low memory B lymphocyte value 32.[] Impaired NK cell function Decreased plasmacytoid dendritic cell numbers Decreased expression of TNF-alpha, IFN- gamma and IL-2 Cur Opin Hematol 2015, 22:12-22 31.[]

  • Immunosuppressive Drug

    However, the amount of CN Aα protein in the naive CD4 T cells was increased about twofold ( Fig. 2 D), and there was a substantial decrease in the level of CN phosphatase[] […] activity detected in the dnCN Tg naive CD4 T cells ( Fig. 2 E).[]

  • Interleukin-2

    In naive Th cells, Ets-2 mRNA expression, Ets-2 protein levels, and Ets-2 binding to ARRE-2 decrease upon cell activation followed by the concomitant expression of IL-2.[] Ets-2 acts as an independent preinduction repressor in naive Th cells and does not interact physically with the transcription factor NFAT (nuclear factor of activated T-cells[]

  • Human Herpesvirus 3

    […] cohort, defined as a 0.5-log increase 1 month after vaccination, compared with the levels at screening or the previous vaccination visit) or in CD4 T-cell count (defined[] Worsening of HIV disease was defined as a prespecified change in HIV RNA level (for ART cohorts, defined as detectable HIV RNA 1 month after vaccination; for the ART-naive[] […] as a 30% decrease at months 1–7, compared with the count at screening or the previous vaccination visit), emergence of an AIDS-defining condition, or a change to ART because[]

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