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106 Possible Causes for Levels of Vitamin B12 Elevated, Splenomegaly

  • Autoimmune Lymphoproliferative Syndrome

    […] numbers of double-negative T cells, autoimmune cytopenias, and increased levels of vitamin B12 and interleukin-10.[] We conclude that in selected patients with marked splenomegaly and ALPS, splenectomy may be considered a treatment option.[] All five children had splenomegaly, cytopenias, and hypertriglyceridemia at presentation; four had lymphadenopathy.[]

  • Thrombotic Thrombocytopenic Purpura

    Vitamin B12 deficiency can lead to elevated levels of homocysteine in the blood.[] Splenomegaly. Investigations [ 2 ] Blood smear shows fragmented erythrocytes, ie schistocytes. This is consistent with haemolysis.[] Treatment with intramuscular vitamin B12 was initiated, which resulted in dramatic neurologic and hematologic improvement.[]

  • Chronic Neutrophilic Leukemia

    After anti-tuberculous therapy for 1 year, the patient underwent splenectomy for massive splenomegaly and progressive leukocytosis.[] […] serum levels of vitamin B12 and uric acid, a low serum level of granulocyte colony-stimulating factor, and high serum IgM (1015 mg/dl: lambda type M protein).[] The patient showed sustained mature neutrophilic leukocytosis, splenomegaly, a high leukocyte alkaline phosphatase score, elevated serum vitamin B12 and uric acid, myeloid[]

  • Vitamin E Deficiency

    Mild fat malabsorption, lactic acidosis, and severe deficiency of vitamins A and E and carotene were documented. Serum B12 and folic acid levels were normal.[] Autopsy revealed intrahepatic cholestatic cirrhosis without obliterative lesions in the bile duct system and marked splenomegaly with splenoma-like nodules.[] During vitamin A and E therapy sufficient to elevate serum levels to the normal range, there was improvement of visual fields and visual acuity in dim light, lactic acidosis[]

  • Cough

    Features of chronic myeloproliferative disease are often present, including splenomegaly and elevated serum vitamin B12 levels.[] Features of chronic myeloproliferative disease are often present, including splenomegaly and elevated serum vitamin B12 levels.[]

  • Chronic Eosinophilic Leukemia

    We present a 24-year-old-male with left lower quadrant abdominal pain, elevated eosinophil counts and splenomegaly.[] The serum vitamin B12 levels were grossly elevated, and Philadelphia chromosome study was negative. Thus, a diagnosis of chronic eosinophilic leukemia was made.[] The only clues for the diagnosis of leukemia were splenomegaly and high serum vitamin B12, most of which was bound to transcobalamin I.[]

  • Sjogren's Syndrome

    Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements.[] On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly.[] Clinical predictors of lymphoma development in SS include persistently enlarged parotid glands, with associated splenomegaly, lymphadenopathy, and cutaneous vasculitis (palpable[]

  • Vitamin Deficiency

    Hepatomegaly and splenomegaly may occur. In carotenosis, the skin (but not the sclera) becomes deep yellow, especially on the palms and soles.[] Folate, vitamin B12 and B6 levels were significantly decreased and associated with elevated Hcy levels in PEXG.[] An elevated blood homocysteine level or elevated methylmalconic acid level may also suggest a B12 deficiency.[]

  • Gaisbock's Syndrome

    […] in elevated leukocyte alkaline phosphatase, and elevated serum vitamin B12 level[] Gaisböck disease - polycythemia associated with hypertension but without splenomegaly. Synonym(s): Gaisböck syndrome ; polycythemia hypertonica[] […] polycythaemia associated with hypertension , but without splenomegaly . Synonyms: Gaisbock's syndrome . American spelling: polycythemia hypertonica (05 Mar 2000)[]

  • Pernicious Anemia

    Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity[] Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[] Hepatomegaly and splenomegaly may be present.[]

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