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70 Possible Causes for Levels of Vitamin B12 Elevated, Splenomegaly

  • Autoimmune Lymphoproliferative Syndrome

    […] numbers of double-negative T cells, autoimmune cytopenias, and increased levels of vitamin B12 and interleukin-10.[] We conclude that in selected patients with marked splenomegaly and ALPS, splenectomy may be considered a treatment option.[] All five children had splenomegaly, cytopenias, and hypertriglyceridemia at presentation; four had lymphadenopathy.[]

  • Liver Cirrhosis

    Supraphysiological levels of homocysteine irritate blood vessels and are associated with an increased risk of thrombosis. 36 Homocysteine is often elevated due to a vitamin[] We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[] Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively.[]

  • Hereditary Spherocytosis

    Her red cell folate, vitamin B12 and ferritin levels were normal.[] Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[] MATERIALS AND METHODS: A retrospective review was conducted to evaluate all SILS for splenomegaly performed by a single surgeon.[]

  • Leukemia

    […] serum tryptase and/or vitamin B12 levels may be observed with myeloid neoplasms, particularly in cases with PDGFRA or PDGFRB fusion genes. 5, 13 Increased serum tryptase[] Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[] […] leukemia (T-PLL) is the most common type of mature T-cell leukemia and is characterized by a rapidly rising peripheral blood lymphocyte count, bone marrow involvement, and splenomegaly[]

  • Pernicious Anemia

    Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity[] Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[] Hepatomegaly and splenomegaly may be present.[]

  • Polycythemia Vera

    Polycythemia Vera Laboratory findings Elevated Hct – often 60% Increased WBCs and platelets Serum EPO levels are low Decreased iron stores (Ferritin) Increased Vitamin B12[] […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[] Vitamin B12 level Plethora, a ruddy complexion of face, palms, nail beds, mucosa, and conjunctiva, due to the increased total red blood cell count.[]

  • Autoimmune Lymphoproliferative Syndrome Type 3

    […] in DNTs 3: Elevated serum IgG 4: Elevated serum IL-10 5: Elevated serum vitamin B12 6: Elevated plasma Fas ligand level Diagnosis established if 3 major criteria present[] […] of red blood cells hemolytic anemia), Decreased platelets in the blood ( thrombocytopenia ), Enlargement of lymph nodes (lymphadenopathy), and Enlargement of the spleen (splenomegaly[] The laboratory finding of increased alpha beta TCR DNT cells is consistent with ALPS only with the appropriate clinical picture (nonmalignant lymphadenopathy, splenomegaly[]

  • Sjogren's Syndrome

    Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements.[] On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly.[] […] development of NHL lymphoma include low complements (C3 and C4), presence of cryoglobulins, low CD4:CD8 ratio, persistence of unilateral or bilateral parotid gland enlargement, splenomegaly[]

  • Lymphoproliferative Syndrome 1

    Secondary: Elevated plasma sFASL levels ( 200 pg/mL), plasma IL-10 levels ( 20 pg/mL), serum or plasma vitamin B12 levels ( 1500 ng/L) or plasma IL-18 levels 500 pg/mL.[] Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.[] Abdomen Fulminant hepatitis Liver failure Gastrointestinal Hepatomegaly Splenomegaly General Reduced life expectancy, death by 10 years of age in 70% of patients Hematologic[]

  • Paroxysmal Nocturnal Hemoglobinuria

    […] parameters, renal function, folic acid and vitamin B12 levels, iron status and (pro)BNP for the assessment of right ventricular function should be investigated.[] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[]

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