931 Possible Causes for Li-Fraumeni Syndrome

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  • Leukemia

    Also, children who have inherited certain genetic problems — such as Li-Fraumeni syndrome, Down syndrome , Klinefelter syndrome , neurofibromatosis , ataxia telangectasia,[kidshealth.org] Children with certain genetic conditions, such as Down syndrome or Li-Fraumeni syndrome, are at increased risk of developing leukemia.[stanfordchildrens.org] Children with certain genetic syndromes, including Fanconi anemia, Bloom syndrome, Kostmann syndrome, and Down syndrome, are at a higher risk of developing AML than other[stanfordchildrens.org]

  • Malignant Neoplasm of the Breast

    Li-Fraumeni syndrome: Characterized by early onset breast cancers, sarcomas, brain tumours, adrenal cortical tumours and acute leukemias.[pathophys.org] […] ovarian cancer other genetic relationships RAS oncogene gain of function overexpression of estrogen/progesterone receptors overexpression of erb -B2 (HER-2, an EGF receptor) Li-Fraumeni[medbullets.com] These mutations account for up to 90% of the total genetic influence with a risk of breast cancer of 60–80% in those affected. [58] Other significant mutations include p53 ( LiFraumeni[en.wikipedia.org]

  • Malignant Melanoma
  • Li-Fraumeni Syndrome

    Increased oxidative metabolism in the Li-Fraumeni syndrome.[p53.iarc.fr] Description Li-Fraumeni syndrome (LFS) was first described by Dr. Frederick Li and Dr. Joseph Fraumeni in 1969.[encyclopedia.com] External links Wikipedia : entry on Li Fraumeni syndrome YouTube : search result for "Li Fraumeni syndrome" Last updated: 23/04/17[genetics4medics.com]

  • Li-Fraumeni Syndrome 1

    Increased oxidative metabolism in the Li-Fraumeni syndrome.[p53.iarc.fr] PMID 10617473 Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.[atlasgeneticsoncology.org] Li FP, Fraumeni JF Jr, Mulvihill JJ et al. (1988) A cancer family syndrome in twenty‐four kindreds. Cancer Research 48: 5358–5362.[els.net]

  • Familial Hyperlipidemia

    (such as Li-Fraumeni Syndrome) at an early age.[advancejournals.org] Mutations of germ-cell line TP53 gene are mainly reported in LiFraumeni syndrome(LFS).[advancejournals.org] Lateonset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report andreview of the literature.[advancejournals.org]

  • Genetic Mosaic

    References Somatic TP53 mutation mosaicism in a patient with Li-Fraumeni syndrome.[livinglfs.org] Li-Fraumeni Syndrome can be frustrating. There are so many parts of the disease and the mutations that are just not understood yet.[livinglfs.org] […] you have certain cancer types that are considered LFS core cancers and other criteria for having LFS but no mutations that are known, you might be mosaic, you might have Li-Fraumeni[livinglfs.org]

  • Triple A Syndrome

    What is Li-Fraumeni syndrome? The Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome first reported in 1969 by Drs.[cancer.net] Li-Fraumeni-like Syndrome (LFL) is another, similar set of criteria for affected families who do not meet Classic criteria (see above).[cancer.net] Frederick Li and Joseph Fraumeni from the National Cancer Institute.[cancer.net]

  • Eng-Strom Syndrome

    Prenatal diagnosis in Li-Fraumeni syndrome.[ncbi.nlm.nih.gov] The TP53 mutation R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndrome in Brazilian families.[ncbi.nlm.nih.gov] Germline TP53 mutations and Li-Fraumeni syndrome.[ncbi.nlm.nih.gov]

  • Myositis

Further symptoms