21 Possible Causes for Li Fraumeni Syndrome in USA

  • Li-Fraumeni Syndrome

    OSLAM syndrome LiFraumeni syndrome, in the National Library of Medicine Genetics Home Reference (an introduction to the disease) LiFraumeni Syndrome by Katherine A Schneider … Many individuals with LiFraumeni syndrome have been shown to be heterozygous for a TP53 mutation. … LiFraumeni syndrome (LFS) is relatively rare; as of 2011, cases had been reported in more than 500 families.[1]

  • Choroid Plexus Carcinoma

    The sometimes occur in conjunction with other hereditary cancers, including LiFraumeni syndrome and malignant rhabdoid tumors.[2]

  • Anaplastic Astrocytoma

    The main hereditary predispositions are mainly neurofibromatosis type I, Li-Fraumeni syndrome, hereditary nonpolyposis colorectal cancer and tuberous sclerosis.[3]

  • Embryonal Rhabdomyosarcoma

    Rhabdomyosarcomas can arise as isolated lesions, or as a part of several clinical syndromes, including Li-Fraumeni syndrome, neurofibromatosis type 1, Costello syndrome, Noonan … syndrome and Beckwith-Wiedemann syndrome.[4]

  • Spindle Cell Sarcoma

    Genetic factors play a major role in SCS etiology; patients suffering from the Li-Fraumeni syndrome, neurofibromatosis type I, Rothmund Thomson syndrome, and Werner syndrome[5]

  • Adrenocortical Carcinoma

    Families with LiFraumeni syndrome have increased risk. … The role of tumor suppressor gene mutations is suggested by their association with Li-Fraumeni syndrome, which is characterized by inactivating germline mutations of the TP53 … syndrome, Conn syndrome, virilization, and feminization.[6] [7]

  • Glioblastoma Multiforme

    Uncommon risk factors include genetic disorders such as neurofibromatosis, LiFraumeni syndrome, tuberous sclerosis, or Turcot syndrome. … Uncommon risk factors include genetic disorders such as neurofibromatosis and LiFraumeni syndrome and, previous radiation therapy. … Those receiving phenytoin concurrent with radiation may have serious skin reactions such as erythema multiforme and Stevens–Johnson syndrome.[8]

  • Osteosarcoma

    LiFraumeni syndrome (germline TP53 mutation) is a predisposing factor for osteosarcoma development. … Rothmund–Thomson syndrome (i.e. autosomal recessive association of congenital bone defects, hair and skin dysplasias, hypogonadism, and cataracts) is associated with increased … [9]

  • Leiomyosarcoma

    Familial syndromes - Several hereditary syndromes, such as Li-Fraumeni syndrome, Rothmund-Thompson syndrome, neurofibromatosis, enchondromatosis, and retinoblastoma carry … [10]

  • Acute Myelocytic Leukemia

    syndrome, Li-Fraumeni syndrome, Patau syndrome, Shwachman syndrome Hematological disorders, e.g., myelodysplasia Prior cytotoxic chemotherapy with alkylating agents, anthracyclines … Few cases are related to Down syndrome, Klinefelter syndrome, myelodysplasia, prior cytotoxic chemotherapy, as well as exposure to chemical carcinogens and radiation, but … In this context, the following risk factors have been identified: Genetic diseases like ataxia telangiectasia, congenital neutropenia, Down syndrome, Fanconi syndrome, Klinefelter … [11]

Further symptoms

Similar symptoms


  1. Li–Fraumeni syndrome, Wikipedia, CC-BY-SA-3.0
  2. Choroid plexus carcinoma, Wikipedia, CC-BY-SA-3.0
  3. Anaplastic astrocytoma, Wikipedia, CC-BY-SA-3.0
  4. Embryonal Rhabdomyosarcoma, Symptoma
  5. Spindle Cell Sarcoma, Symptoma
  6. Adrenocortical Carcinoma, Symptoma
  7. Adrenocortical carcinoma, Wikipedia, CC-BY-SA-3.0
  8. Glioblastoma, Wikipedia, CC-BY-SA-3.0
  9. Osteosarcoma, Wikipedia, CC-BY-SA-3.0
  10. Leiomyosarcoma, Symptoma
  11. Acute Myelocytic Leukemia, Symptoma