79 Possible Causes for Li Fraumeni Syndrome in USA

  • Li-Fraumeni Syndrome

    OSLAM syndrome LiFraumeni syndrome, in the National Library of Medicine Genetics Home Reference (an introduction to the disease) LiFraumeni Syndrome by Katherine A Schneider … Many individuals with LiFraumeni syndrome have been shown to be heterozygous for a TP53 mutation. … LiFraumeni syndrome (LFS) is relatively rare; as of 2011, cases had been reported in more than 500 families.[1]

  • Glioblastoma Multiforme

    account for approximately 5% of malignant gliomas, and less than 1% of gliomas are associated with a known genetic syndrome (eg, neurofibromatosis , Turcot syndrome, or Li-Fraumenisyndrome ). [1] Although concerns have been raised regarding cell phone use as a potential risk factor for development of gliomas, study results have been inconsistent, and … GeneReviews says that Li-Fraumeni syndrome predisposes patients to brain tumors and other cancers, including soft-tissue sarcoma and adrenocortical carcinoma.[2] [3]

  • Hereditary Breast Cancer

    In addition, management for individuals with well-defined high-risk syndromes such as Li-Fraumeni syndrome and phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome … Li-Fraumeni and Cowden syndromes, which are related to mutations in the TP53 and PTEN genes, respectively (see "PTEN hamartoma tumor syndrome, including Cowden syndrome" and "Li-Fraumenisyndrome" ).[4]

  • Adrenocortical Carcinoma

    These include Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and Carney complex. … The following syndromes are associated with ACC: Li- Fraumeni Syndrome Li-Fraumeni Syndrome (LFS) is an autosomal dominant disorder caused by a germ-line mutation in the TP53 … Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations .[5] [6]

  • Embryonal Rhabdomyosarcoma

    Rhabdomyosarcomas can arise as isolated lesions, or as a part of several clinical syndromes, including Li-Fraumeni syndrome, neurofibromatosis type 1, Costello syndrome, Noonan … However, it has been associated with some inherited diseases including: Neurofibromatosis type 1 Beckwith-Wiedemann syndrome Li-Fraumeni syndrome Cardio-facio-cutaneous syndrome … Rhabdomyosarcomas are also more common in children with neurofibromatosis or Li-Fraumeni syndrome, which are genetic disorders.[7] [8] [9]

  • Malignant Glioma

    GBMs and anaplastic astrocytoma occur with increased frequency in children with certain genetic syndromes, including neurofibromatosis 1, Li-Fraumeni syndrome, hereditary … Additionally, patients suffering from hereditary disorders such as neurofibromatosis type 1, Turcot syndrome, or Li-Fraumeni syndrome have a higher risk of developing malignant … Specifically, the Li-Fraumeni syndrome, p53 defects, neurofibromatosis 1 (NF1) and 2 (NF2), tuberous sclerosis, von Hippel-Lindau disease, Turcot's syndrome, and familial[10] [11] [12]

  • Anaplastic Astrocytoma

    GBMs and anaplastic astrocytoma occur with increased frequency in children with certain genetic syndromes, including neurofibromatosis 1, Li-Fraumeni syndrome, hereditary … Children in families with neurofibromatosis type I, Li-Fraumeni syndrome, hereditary nonpolyposis colon cancer and tuberous sclerosis are at higher risk of anaplastic astrocytoma … The main hereditary predispositions are mainly neurofibromatosis type I, Li-Fraumeni syndrome, hereditary nonpolyposis colorectal cancer and tuberous sclerosis.[13] [14] [15]

  • Lynch Syndrome

    What is Li-Fraumeni Syndrome? … What causes Li-Fraumeni Syndrome? … How is Li-Fraumeni syndrome inherited?[16]

  • Choroid Plexus Carcinoma

    The sometimes occur in conjunction with other hereditary cancers, including LiFraumeni syndrome and malignant rhabdoid tumors.[17]

  • Spindle Cell Sarcoma

    Genetic factors play a major role in SCS etiology; patients suffering from the Li-Fraumeni syndrome, neurofibromatosis type I, Rothmund Thomson syndrome, and Werner syndrome … Li-Fraumeni syndrome increases the risk of many kinds of cancer, often from radiation exposure. … Risk factors for childhood soft tissue sarcoma include having the following inherited disorders: Li-Fraumeni syndrome.[18] [19] [20]

Further symptoms

Similar symptoms

References

  1. Li–Fraumeni syndrome, https://en.wikipedia.org/wiki/Li%E2%80%93Fraume…
  2. Glioblastoma Multiforme Clinical Presentation: History, Physical, Causes, http://emedicine.medscape.com/article/283252-cl…
  3. Causes of a Glioblastoma Multiforme Brain Tumor, http://www.livestrong.com/article/239203-causes…
  4. Management of patients at high risk for breast and ovarian cancer, http://www.uptodate.com/contents/management-of-…
  5. Adrenocortical Carcinoma—Patient Version - National Cancer Institute, http://www.cancer.gov/types/adrenocortical
  6. Adrenocortical Carcinoma and Synchronous Malignancies, http://www.jcancer.org/v01p0108.htm
  7. Rhabdomyosarcoma, http://www.stanfordchildrens.org/en/topic/defau…
  8. Embryonal Rhabdomyosarcoma, https://www.symptoma.com/en/info/embryonal-rhab…
  9. Rhabdomyosarcoma in Children - Just Diagnosed, http://curesearch.org/Rhabdomyosarcoma-Just-Dia…
  10. Childhood Glioblastoma Multiforme and Anaplastic Astrocytoma - Dana-Farber Cancer Institute, http://www.dana-farber.org/Health-Library/Child…
  11. Brain Tumors: Meningiomas and Gliomas, http://www.clevelandclinicmeded.com/medicalpubs…
  12. Malignant Glioma, https://www.symptoma.com/en/info/malignant-glioma
  13. Childhood Glioblastoma Multiforme and Anaplastic Astrocytoma - Dana-Farber Cancer Institute, http://www.dana-farber.org/Health-Library/Child…
  14. Anaplastic Astrocytoma | Boston Children's Hospital, http://www.childrenshospital.org/conditions-and…
  15. Anaplastic astrocytoma, https://en.wikipedia.org/wiki/Anaplastic_astrocytoma
  16. I Have Lynch Syndrome -, http://www.ihavelynchsyndrome.com/
  17. Choroid plexus carcinoma, https://en.wikipedia.org/wiki/Choroid_plexus_carcinoma
  18. Spindle Cell Sarcoma, https://www.symptoma.com/en/info/spindle-cell-sarcoma
  19. Childhood Soft Tissue Sarcoma Symptoms & Treatment, http://my.clevelandclinic.org/health/diseases_c…
  20. Soft Tissue Sarcoma (Rhabdomyosarcoma), http://www.healthline.com/health/rhabdomyosarcoma