OSLAM syndromeLi–Fraumenisyndrome, in the National Library of Medicine Genetics Home Reference (an introduction to the disease)
Li–FraumeniSyndrome by Katherine A Schneider … Many individuals with Li–Fraumenisyndrome have been shown to be heterozygous for a TP53 mutation. … Li–Fraumenisyndrome (LFS) is relatively rare; as of 2011, cases had been reported in more than 500 families.
Rhabdomyosarcomas can arise as isolated lesions, or as a part of several clinical syndromes, including Li-Fraumenisyndrome, neurofibromatosis type 1, Costello syndrome, Noonan … syndrome and Beckwith-Wiedemann syndrome.
Families with Li–Fraumenisyndrome have increased risk. … The role of tumor suppressor gene mutations is suggested by their association with Li-Fraumenisyndrome, which is characterized by inactivating germline mutations of the TP53 … syndrome, Conn syndrome, virilization, and feminization.
Uncommon risk factors include genetic disorders such as neurofibromatosis, Li–Fraumenisyndrome, tuberous sclerosis, or Turcot syndrome. … Uncommon risk factors include genetic disorders such as neurofibromatosis and Li–Fraumenisyndrome and, previous radiation therapy. … Those receiving phenytoin concurrent with radiation may have serious skin reactions such as erythema multiforme and Stevens–Johnson syndrome.
Li–Fraumenisyndrome (germline TP53 mutation) is a predisposing factor for osteosarcoma development. … Rothmund–Thomson syndrome (i.e. autosomal recessive association of congenital bone defects, hair and skin dysplasias, hypogonadism, and cataracts) is associated with increased … 
syndrome, Li-Fraumenisyndrome, Patau syndrome, Shwachman syndrome Hematological disorders, e.g., myelodysplasia Prior cytotoxic chemotherapy with alkylating agents, anthracyclines … Few cases are related to Down syndrome, Klinefelter syndrome, myelodysplasia, prior cytotoxic chemotherapy, as well as exposure to chemical carcinogens and radiation, but … In this context, the following risk factors have been identified: Genetic diseases like ataxia telangiectasia, congenital neutropenia, Down syndrome, Fanconi syndrome, Klinefelter …