Limb Spasticity: Causes & Reasons

Possible Causes for Limb Spasticity

Infantile-Onset Ascending Hereditary Spastic Paralysis

[…] and weakness, people with spastic paraplegia type 5A can lose the ability to sense the position of their limbs or detect vibrations with their lower limbs. [icdlist.com]

is a very rare motor neuron disease characterized by severe spasticity of the lower limbs in early life, progression of spasticity to the upper limbs in late childhood, [amp.pharm.mssm.edu]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Spastic Paraplegia

Familial spastic paraplegia (FSP) is a heterogeneous group of disorders characterized primarily by progressive lower limb spasticity and weakness. [ncbi.nlm.nih.gov]

The primary clinical signs include progressive spasticity and weakness of lower limbs and hip muscles. [bmcresnotes.biomedcentral.com]

Though the primary features of "pure" HSP are progressive lower limb spasticity and weakness, complicated forms may be accompanied by other symptoms. [ninds.nih.gov]

Fitzsimmons-McLachlan-Gilbert Syndrome

[…] has characteristics of intellectual deficit, spasticity in the lower limbs (spastic paraplegia), pes cavus deformity of both feet, an abnormal gait, and palmar and plantar [bioportal.bioontology.org]

Three of the affected individuals have spasticity in the lower limbs (spastic paraplegia), pes cavus deformity of both feet and an abnormal gait. [ncbi.nlm.nih.gov]

Three of the affected individuals have spasticity in the lower limbs (spastic paraplegia), pes caws deformity of both feet and an abnormal gait. [onlinelibrary.wiley.com]

Spastic Quadriplegic Cerebral Palsy Type 2

[…] and weakness, people with spastic paraplegia type 5A can lose the ability to sense the position of their limbs or detect vibrations with their lower limbs. [icdlist.com]

Spastic quadriplegia, also known as spastic tetraplegia, is a subset of spastic cerebral palsy that affects all four limbs (both arms and legs). [en.wikipedia.org]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Cerebral Palsy with Spastic Diplegia

The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. [fpnotebook.com]

G83.0 ICD-10-CM Diagnosis Code G83.0 Diplegia of upper limbs 2016 2017 2018 2019 Billable/Specific Code Applicable To Diplegia (upper) Paralysis of both upper limbs spastic [icd10data.com]

Effect on the upper limbs (arms and hands) If spasticity affects one or both of the arms it can lead to: Flexion at the elbow (the elbow is bent) Flexion at the wrist (the [cerebralpalsy.org.au]

Pure Hereditary Spastic Paraplegia

spasticity. [austinpublishinggroup.com]

Abstract Autosomal dominant pure hereditary spastic paraplegia (ADPHSP) is clinically characterized by slowly progressive lower-limb spasticity. [ncbi.nlm.nih.gov]

[…] and weakness, people with spastic paraplegia type 5A can lose the ability to sense the position of their limbs or detect vibrations with their lower limbs. [icdlist.com]

Autosomal Dominant Spastic Paraplegia Type 10

[…] can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia and extensor plantar responses, presenting in childhood or adolescence, or [orpha.net]

is a rare type of hereditary spastic paraplegia that can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia and extensor plantar [orpha.net]

[…] usually presents in late adolescence or early adulthood as a pure phenotype of lower limb spasticity with hyperreflexia and extensor plantar responses, as well as mild bladder [orpha.net]

Autosomal Dominant Spastic Paraplegia Type 6

[…] usually presents in late adolescence or early adulthood as a pure phenotype of lower limb spasticity with hyperreflexia and extensor plantar responses, as well as mild bladder [orpha.net]

[…] muscle weakness Lower extremity weakness Lower limb weakness Muscle weakness in lower limbs [ more ] 0007340 Lower limb spasticity 0002061 Progressive Worsens with time 0003676 [rarediseases.info.nih.gov]

Homepage Rare diseases Search Search for a rare disease Autosomal dominant spastic paraplegia type 6 Disease definition A rare form of hereditary spastic paraplegia which [orpha.net]

Autosomal Recessive Spastic Paraplegia Type 56

[…] weakness and spasticity of the lower limbs. [malacards.org]

People with the pure form of spastic paraplegia type 2 experience spasticity in the lower limbs, usually without any additional features. [ghr.nlm.nih.gov]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Autosomal Dominant Spastic Paraplegia Type 17

[…] weakness and spasticity of the lower limbs. [malacards.org]

[…] usually presents in late adolescence or early adulthood as a pure phenotype of lower limb spasticity with hyperreflexia and extensor plantar responses, as well as mild bladder [orpha.net]

[…] syndromes characterized by bilateral lower limb spasticity, or stiffness and weakness, which are caused by gene mutation and therefore they are inherited. [hstalks.com]

Autosomal Recessive Spastic Paraplegia Type 27

27, Autosomal Recessive Symptoms via clinical synopsis from OMIM: 57 Neurologic Central Nervous System: dysarthria lower limb spasticity lower limb hyperreflexia extensor [malacards.org]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

The disease presents with progressive stiffness (spasticity) and contraction in the lower limbs.[1] HSP is also known as hereditary spastic paraparesis, familial spastic paraplegia [en.wikipedia.org]

Hereditary Spastic Paraplegia

Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of inherited neurodegenerative disorders with weakness and spasticity of the lower limbs as its main clinical [omicsonline.org]

limb spasticity that can occur alone or in combination with a constellation of other neurological or systemic signs and symptoms. [ncbi.nlm.nih.gov]

Hereditary spastic paraplegias are a heterogeneous group of chronic central motor system disorders, characterised by progressive lower limb spasticity. [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 64

spasticity and developmental delay Developmental delay and marked lower limbs spasticity Delayed walking Speech delay + (speech started at age 3 years) + (speech started [bmcmedgenet.biomedcentral.com]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

[…] are characterized by the presence of lower limb spasticity and weakness. [neurologyindia.com]

Autosomal Recessive Spastic Paraplegia Type 26

More on Lower limb spasticity » Causes of Lower limb spasticity Some of the causes of the condition may include: Causes of Lower Limb Spasticity : 2p15p16.1 Microdeletion [familydiagnosis.com]

[…] weakness and spasticity of the lower limbs. [malacards.org]

[…] are characterized by the presence of lower limb spasticity and weakness. [neurologyindia.com]

Autosomal Recessive Spastic Paraplegia Type 7

SPG7 is characterized by insidiously progressive bilateral lower limb weakness and spasticity (Tables 82.1 and 82.2). [link.springer.com]

[…] and weakness, people with spastic paraplegia type 5A can lose the ability to sense the position of their limbs or detect vibrations with their lower limbs. [icdlist.com]

Spastic paraplegia type 7 is an autosomal recessive neurodegenerative disorder mainly characterized by progressive bilateral lower limb spasticity and referred to as a form [hspersunite.org.au]

Diomedi-Bernardi-Placidi Syndrome

The primary clinical signs include progressive spasticity and weakness of lower limbs and hip muscles. [bmcresnotes.biomedcentral.com]

The most common symptom at onset was related to lower limbs spasticity in the vast majority of cases. [jnnp.bmj.com]

limb spasticity. [ruralneuropractice.com]

Autosomal Dominant Spastic Paraplegia Type 29

[…] weakness and spasticity of the lower limbs. [malacards.org]

Not very common - Between 30% and 50% cases Upper limb spasticity Commonly - More than 50% cases Impaired proprioception Not very common - Between 30% and 50% cases Hiatus [mendelian.co]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Autosomal Recessive Spastic Paraplegia Type 20

[…] and weakness, people with spastic paraplegia type 5A can lose the ability to sense the position of their limbs or detect vibrations with their lower limbs. [icdlist.com]

People with the pure form of spastic paraplegia type 2 experience spasticity in the lower limbs, usually without any additional features. [ghr.nlm.nih.gov]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Autosomal Recessive Spastic Paraplegia Type 48

Hereditary spastic paraplegias (HSP) constitute a rare and highly heterogeneous group of neurodegenerative disorders, defined clinically by progressive lower limb spasticity [mobile.fluidigm.com]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

spasticity (Silver-like syndrome) due to a mutation in the sigma nonopioid YouTube October 25, 2016 [aan.com]

X-Linked Spastic Paraplegia Type 2

[…] system resulting primarily in limb spasticity, cognitive impairment, nystagmus, and spastic urinary bladder of varying severity. [ncbi.nlm.nih.gov]

[…] and weakness, people with spastic paraplegia type 5A can lose the ability to sense the position of their limbs or detect vibrations with their lower limbs. [icdlist.com]

Systemic Features: This is a complex form of spastic paraplegia in which primarily lower limb spasticity is associated with dysarthria, sensory disturbances, cognitive deficits [disorders.eyes.arizona.edu]

Autosomal Recessive Spastic Paraplegia Type 18

People with the pure form of spastic paraplegia type 2 experience spasticity in the lower limbs, usually without any additional features. [ghr.nlm.nih.gov]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Autosomal Recessive Spastic Paraplegia Type 61

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Spasticity in the lower limbs alone is described as pure SPG. [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 39

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

[…] disorders characterized by varying degrees of lower limb spasticity, pyramidal weakness, hyperreflexia and hypertonic bladder involvement. [medicbind.com]

[…] are characterized by the presence of lower limb spasticity and weakness. [neurologyindia.com]

Autosomal Dominant Spastic Paraplegia Type 42

[…] syndromes characterized by bilateral lower limb spasticity, or stiffness and weakness, which are caused by gene mutation and therefore they are inherited. [hstalks.com]

People with the pure form of spastic paraplegia type 2 experience spasticity in the lower limbs, usually without any additional features. [ghr.nlm.nih.gov]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Autosomal Dominant Spastic Paraplegia Type 31

[…] syndromes characterized by bilateral lower limb spasticity, or stiffness and weakness, which are caused by gene mutation and therefore they are inherited. [hstalks.com]

The most common symptom at onset was related to lower limbs spasticity in the vast majority of cases. [jnnp.bmj.com]

Case Report The index case is a girl with muscle weakness and spasticity of the lower limbs. Birth and neonatal periods were normal. [omicsonline.org]

Autosomal Recessive Spastic Paraplegia Type 44

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

Hand tremor and upper limb spasticity have also been reported. Onset can range from infancy to older adulthood. [flybase.org]

Autosomal Dominant Spastic Paraplegia Type 4

spasticity and weakness as well as very mild proximal weakness and urinary urgency. [orpha.net]

[…] usually presents in late adolescence or early adulthood as a pure phenotype of lower limb spasticity with hyperreflexia and extensor plantar responses, as well as mild bladder [orpha.net]

The clinical features were hyperreflexia in all four limbs, spasticity of the lower extremities, impaired vibration sense, mild… CONTINUE READING [semanticscholar.org]

Autosomal Dominant Spastic Paraplegia Type 9A

Muscular atrophy and peripheral neuropathy in addition to lower limb spasticity are observed in several forms of HSP, including SPG10/17/19 (autosomal dominant) as well as [thieme-connect.com]

[…] are characterized by the presence of lower limb spasticity and weakness. [neurologyindia.com]

The phenotype (SPG31) has occasionally been described with peripheral nervous system involvement, in additional to the gradually progressing lower limb spasticity that characterizes [readbyqxmd.com]

Autosomal Recessive Spastic Paraplegia Type 63

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]

spasticity (Silver-like syndrome) due to a mutation in the sigma nonopioid YouTube October 25, 2016 [aan.com]

Autosomal Dominant Spastic Paraplegia Type 8

Other features may include upper limb spasticity, impaired vibration sense in the distal lower limbs, and urinary urgency or incontinence (summary by {1:de Bot et al., 2013 [diseaseinfosearch.org]

[…] paraplegia 8 is a neurologic disorder characterized by severe lower limb spasticity and weakness. [cags.org.ae]

The disease presents with progressive stiffness ( spasticity ) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic [en.wikipedia.org]