Vitamin B12 Deficiency
Abstract A 23-year-old man presented with weakness in the lower limbs, numbness in hands and feet over past 6 months.[ncbi.nlm.nih.gov]
He presented with weakness and numbness of the distal limbs and absent deep tendon reflex in all four extremities.[ncbi.nlm.nih.gov]
[…] headache – cognitive problems, such as memory loss and difficulty concentrating – pale or yellow skin (jaundice) – stomach upset and weight loss – changed sensation in the limbs[healthyandnaturalworld.com]
Lumbar Disk Herniation
In some cases, it can lead to pain, numbness, or weakness in the limbs. However, some people experience no pain, particularly if the disk does not press on any nerves.[medicalnewstoday.com]
Weakness in your limb muscles is also of some concern. If you experience arm, hand, leg or foot weakness, you are strongly advised to seek prompt medical assessment. 3.[physioworks.com.au]
Hypothyroidism
Debra Counts , MD * Surendra K. Varma , MD † * Associate Professor of Pediatrics; Chief, Division of Pediatric Endocrinology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Md † Editorial Board AAP: American Academy of Pediatrics CNS: central nervous system IQ: intellectual quotient[…][doi.org]
Polymyalgia Rheumatica
Weak or absent pulses may be noticed by the doctor. These symptoms occur in 15 to 20% of patients.[my.clevelandclinic.org]
If narrowing occurs in the blood vessels leading to the arms or legs, patients may notice fatigue or aching in the limbs because of a reduced blood supply.[my.clevelandclinic.org]
Primary Progressive Multiple Sclerosis
Symptoms can include: Pain (for example, headaches, pain in the legs and feet, back pain, and muscle spasms) Electric-shock sensations that run down the back and limbs when[hopkinsmedicine.org]
Typical symptoms associated with PML are diverse, progress over days to weeks, and include progressive weakness on one side of the body or clumsiness of limbs, disturbance[ocrevus.com]
Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com]
Muscular Dystrophy
The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing[kennedykrieger.org]
Later on, after many years, mild limb weakness around the shoulders and hips may also develop.[patient.info]
Affected individuals develop weakness of the lower limbs that may be mild or severe. Weakness of facial muscles may also occur.[rarediseases.org]
Duchenne Muscular Dystrophy
And 2) are these gait deviations related to lower limb weakness?[ncbi.nlm.nih.gov]
Abstract Duchenne muscular dystrophy (DMD) is an X-linked form of muscular dystrophy characterized by progressive limb-girdle distribution of muscle weakness.[ncbi.nlm.nih.gov]
DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness.[medterms.com]
Multifocal Motor Neuropathy
Multifocal motor neuropathy is a disorder characterized by slowly progressive asymmetrical limb weakness and multiple motor conduction blocks.[ncbi.nlm.nih.gov]
Abstract Multifocal motor neuropathy (MMN) is typically associated with distal upper limb weakness and wasting.[ncbi.nlm.nih.gov]
Abstract Multifocal motor neuropathy with conduction block (MMNcb) is a relatively rare disease characterized clinically by asymmetric limb weakness with spared sensation[ncbi.nlm.nih.gov]
Chronic Inflammatory Demyelinating Polyneuropathy
He was admitted with bilateral lower limb weakness which was ascending in nature. He eventually required ventilation.[ncbi.nlm.nih.gov]
We described a young girl with CIDP underlying type 2 diabetes mellitus, presenting with progressive numbness and limb weakness, who was initially misdiagnosed to have DPN[ncbi.nlm.nih.gov]
Although at 25 years of age she had already been diagnosed with limb weakness associated with chronic inflammatory demyelinating polyneuropathy (CIDP), she had never experienced[ncbi.nlm.nih.gov]
Motor Neuron Disease
Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[ncbi.nlm.nih.gov]
Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb.[patient.info]
He developed gait disturbance and weakness of lower limbs at age 52 years. Because of progressive muscle weakness and atrophy, he became bed-ridden at age 65.[ncbi.nlm.nih.gov]