Possible Causes for limb weakness Vitamin B12 Deficiency This can result in tingling in the feet and hands, weakness in the limbs, and even loss of sensation. [healthyandnaturalworld.com] A 23-year-old man presented with weakness in the lower limbs, numbness in hands and feet over past 6 months. [ncbi.nlm.nih.gov] He presented with weakness and numbness of the distal limbs and absent deep tendon reflex in all four extremities. [ncbi.nlm.nih.gov] Lumbar Disk Herniation Weakness of affected limb due to possible nerve compression The above symptoms of Lumbar spondylosis which is predominantly due to vitiated Vata dosha. [bodhiwellnesscentre.com] We report a 45-year-old male who presented with sudden onset right lower limb weakness after lifting heavy weight. [read.qxmd.com] In some cases, it can lead to pain, numbness, or weakness in the limbs. However, some people experience no pain, particularly if the disk does not press on any nerves. [medicalnewstoday.com] Hypothyroidism Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. [ncbi.nlm.nih.gov] At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs. [ncbi.nlm.nih.gov] Polymyalgia Rheumatica Weak or absent pulses may be noticed by the doctor. These symptoms occur in 15% to 20% of patients. What are the symptoms of PMR? [my.clevelandclinic.org] Weak or absent pulses may be noticed by the doctor. These symptoms occur in 15 to 20% of patients. [my.clevelandclinic.org] If narrowing occurs in the blood vessels leading to the arms or legs, patients may notice fatigue or aching in the limbs because of a reduced blood supply. [my.clevelandclinic.org] Primary Progressive Multiple Sclerosis The exacerbations manifested as isolated optic neuritis in 9 patients, optic neuritis with limb paresis in 1, isolated diplopia in 2, diplopia with limb weakness in 1, limb [jamanetwork.com] Symptoms can include: Pain (for example, headaches, pain in the legs and feet, back pain, and muscle spasms) Electric-shock sensations that run down the back and limbs when [hopkinsmedicine.org] Pyramidal functional system impairment (ie, limb weakness, spasticity, or hyperreflexia) was seen in the following patterns, typically with sparing of the facial musculature [jamanetwork.com] Muscular Dystrophy The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing [kennedykrieger.org] Later on, after many years, mild limb weakness around the shoulders and hips may also develop. [patient.info] […] about Duchenne muscular dystrophy Facioscapulohumeral Muscular Dystrophy: Facioscapulohumeral (FSH) dystrophy is a common muscular dystrophy in which there is progressive weakness [kennedykrieger.org] Duchenne Muscular Dystrophy And 2) are these gait deviations related to lower limb weakness? [ncbi.nlm.nih.gov] Abstract Duchenne muscular dystrophy (DMD) is an X-linked form of muscular dystrophy characterized by progressive limb-girdle distribution of muscle weakness. [ncbi.nlm.nih.gov] DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness. [medterms.com] Multifocal Motor Neuropathy The initial high-dose intravenous immunoglobulin treatment significantly improved left upper limb muscle weakness. [ncbi.nlm.nih.gov] Multifocal motor neuropathy is a disorder characterized by slowly progressive asymmetrical limb weakness and multiple motor conduction blocks. [ncbi.nlm.nih.gov] Multifocal motor neuropathy (MMN) is typically associated with distal upper limb weakness and wasting. [ncbi.nlm.nih.gov] Chronic Inflammatory Demyelinating Polyneuropathy We described a young girl with CIDP underlying type 2 diabetes mellitus, presenting with progressive numbness and limb weakness, who was initially misdiagnosed to have DPN [ncbi.nlm.nih.gov] Although at 25 years of age she had already been diagnosed with limb weakness associated with chronic inflammatory demyelinating polyneuropathy (CIDP), she had never experienced [ncbi.nlm.nih.gov] He was admitted with bilateral lower limb weakness which was ascending in nature. He eventually required ventilation. [ncbi.nlm.nih.gov] Motor Neuron Disease Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients [ncbi.nlm.nih.gov] Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb. [patient.info] Limb weakness and dysphagia eventually become disabling, although some patients have a primarily bulbar pattern of weakness with relative sparing of limb strength. [emedicine.medscape.com] Limb-Girdle Muscular Dystrophy Limb-girdle muscular dystrophies (LGMD) are a group of clinically and genetically heterogeneous diseases characterized by weakness and wasting of the pelvic and shoulder girdle [ncbi.nlm.nih.gov] PATIENT CONCERNS: A 25-year-old woman was admitted to our department as the limb weakness progressively worsened. [ncbi.nlm.nih.gov] A 40-year-old woman reported exercise-induced calf pain at age 34, followed by progressive lower and upper limb weakness. [ncbi.nlm.nih.gov] Acute Hepatic Porphyria Severe, Diffuse Abdominal Pain1-5 1 Or More Of The Following PERIPHERAL Nervous System Limb weakness or pain CENTRAL Nervous System Anxiety Confusion AUTONOMIC Nervous System [porphyria.ca] Signs and Symptoms of AHP 1 Central Nervous System Confusion Anxiety Seizures Insomnia Hallucinations Depression 2 Peripheral Nervous System Limb weakness or pain Numbness [porphyria.com] Nausea and vomiting Muscular weakness Limb pain Quadriplegia Psychiatric symptoms like psychosis Anxiety Skin rash Blisters on sun-exposed areas Red-brown colored urine Diagnosis [lecturio.com] Myopathy A 47-year-old man with liver cirrhosis developed limb weakness after liver transplantation. [ncbi.nlm.nih.gov] Background Immune-mediated necrotising myopathies are characterised clinically by the subacute onset of proximal limb weakness, accompanied by elevated creatinine kinase levels [ncbi.nlm.nih.gov] The dominant symptoms were exertion induced myalgia and progressive proximal limb weakness in all. 12/19 (63.2%) had classical dropped head syndrome. [ncbi.nlm.nih.gov] Multiple Sclerosis Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination, [ncbi.nlm.nih.gov] Cochrane Database of Systematic Reviews Background Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration [doi.org] She was currently in a remission phase from her MS but with persistent sequelae, including impaired eyesight and muscle weakness of the limbs. [ncbi.nlm.nih.gov] Leigh's Disease There was no fever, seizures, limb weakness, or sensory symptoms. Personal and family history was unremarkable. General and other systemic examination was normal. [annalsofian.org] Exercise intolerance, limb weakness, hearing loss, and diabetes may also precede the occurrence of the stroke-like episodes. [umdf.org] Loss of sensation and weakness in the limbs (peripheral neuropathy), common in people with Leigh syndrome, may also make movement difficult. [mitoaction.org] Erb Muscular Dystrophy Symptoms - Muscular dystrophy limb girdle type 2A- Erb type Muscle weakness is first evident in the shoulder girdle and later in the pelvic girdle. [checkorphan.org] In 1954, when Walton and Nattrass reported 105 cases of limb-girdle weakness associated with many other disorders, the nosologic entity of limb-girdle dystrophy was formally [emedicine.medscape.com] The weakness slowly gets worse, and people may need the aid of a cane or a walker. [icdlist.com] Brachial Plexus Neuropathy Fourteen days post-transplant he developed rapidly progressive proximal weakness in both upper limbs. [nature.com] The disease was characterized by repeated attacks of pain in the upper limb/shoulder region, followed by muscle weakness and atrophy. [ncbi.nlm.nih.gov] Brachial plexus neuropathy is a disorder which usually occurs sporadically, and is characterized by pain and varying degrees of weakness in one or both upper limbs. [ncbi.nlm.nih.gov] Acute Intermittent Porphyria […] lower limbs. [ncbi.nlm.nih.gov] In February 2012, he experienced recurrent urinary retention after onset of intestinal obstruction, irritability, hallucinations and delirium, lower limbs muscle pain, weakness [doi.org] […] or paralysis of the limbs, and psychic changes resembling hysteria. [britannica.com] Facioscapulohumeral Muscular Dystrophy FSHD presentation with foot drop or lower limb proximal weakness appeared to be more frequent than expected. [ncbi.nlm.nih.gov] […] distal (22.45 %) or proximal lower limb weakness (14.8 %). 85.57 % patients were ambulant or ambulant with assistance at the time of registration, 7.9 % report respiratory [ncbi.nlm.nih.gov] The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing [kennedykrieger.org] Polymyositis In her history, she had upper and lower limbs weakness accompanied by dysphagia which was further complicated by right bronchial aspiration 9 months ago. [ncbi.nlm.nih.gov] Examination revealed multiple telangiactasia over face and nail beds and bilateral proximal lower limb weakness of power 4/5. [ncbi.nlm.nih.gov] Muscle weakness is common and mainly involves the ‘proximal’ limb muscles (the muscles around the shoulders, upper arms, pelvis and thighs). [musculardystrophyuk.org] Spinal Cord Compression We report a 7-year-3-month-old girl who suffered from neck pain with restricted movement, poor appetite, body weight loss, mild right limbs weakness, and a non-tender neck [ncbi.nlm.nih.gov] We present the case of a 33-year-old Caucasian woman with a 10-day history of thoracic back pain and a 1-day history of sudden-onset bilateral lower limb weakness and paresthesia [ncbi.nlm.nih.gov] We present a case of 50 year old male who came to the hospital with back pain and progressive bilateral lower limb weakness for the past 6 months. [ncbi.nlm.nih.gov] Bickerstaff Brainstem Encephalitis One patient among Bickerstaff’s original cases had flaccid limb weakness, and BBE cases were divided into ‘BBE without limb weakness’ and ‘BBE with limb weakness’. [doi.org] Table 6 Anti‐ganglioside IgG antibodies for patients with BBE and BBE with limb weakness IgG antibody to BBE, total BBE without limb weakness BBE with limb weakness ( n 62 [doi.org] Table 3 Clinical profiles of patients with BBE and BBE with limb weakness Total BBE without limb weakness BBE with limb weakness Number of patients 62 25 37 Sex (male/female [doi.org] Lambert-Eaton Syndrome Here, we describe a patient with a 5-year history of cervical myelopathy who presented with recurrent limb weakness of her limbs and complained of recent progressive weakness [ncbi.nlm.nih.gov] Neurological examination revealed muscle weakness, predominantly in the proximal parts of the limbs. [ncbi.nlm.nih.gov] A 27-year-old man as initially having the diagnosis of Addison's disease was admitted to the hospital because of fatigue, dry-mouthness and proximal limb weakness for 1 year [ncbi.nlm.nih.gov] Brachial Plexus Neuritis Its classical presentation involves painful progressive asymmetrical upper limb weakness with sensory abnormalities. [jnnp.bmj.com] After infections, surgery or stress Few episodes after 50 years Non-penetrance: Rare Pain Precedes weakness Increased by limb movement Weakness: Multifocal Course: Maximum [neuromuscular.wustl.edu] […] in upper limb muscles and hypertrophy of the brachial plexus brachial plexus hypertrophy can be seen on MRI typically painless INA begins with acute painful phase, followed [orthobullets.com] Glycogen Storage Disease Type 2 There may be limb-girdle weakness and weakness of respiratory muscles.[5] Signs Infantile form: Cardiomegaly and congestive heart failure. [patient.info] The glycogen accumulation leads to myopathy / progressive muscle weakness, notably limb-girdle muscle weakness. [youtube.com] Electromyography may be used initially to distinguish Pompe from other causes of limb weakness. [en.wikipedia.org] Adult Spinal Muscular Atrophy As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles. [cedars-sinai.edu] weakness, hypotonia Bulbar palsy Late Microcephaly Oculomotor defects: strabismus, nystagmus, oculomotor apraxia Cognitive defects Life expectancy 1 year Diagnostics Genetic [amboss.com] In addition to muscle weakness, clinical features include head lag, poor sucking and swallowing, weak cry, proximal limb weakness, and lack of reflexes. [encyclopedia.com] Diabetic Amyotrophy BACKGROUND: People with diabetes mellitus (DM) sometimes present with acute or subacute, progressive, asymmetrical pain and weakness of the proximal lower limb muscles. [ncbi.nlm.nih.gov] […] involving predominantly the proximal muscles of the lower limbs; weakness that is not confined to one nerve or nerve root distribution; and exclusion of other causes of lumbosacral [ncbi.nlm.nih.gov] […] involving predominantly the proximal muscles of the lower limbs, weakness that is not confined to one nerve or nerve root distribution and exclusion of other causes of lumbosacral [ncbi.nlm.nih.gov] Myotonic Dystrophy Patient-reported perceived changes (worse/stable) in balance, walking, lower-limb weakness, stair-climbing and hand weakness were used as criteria. [ncbi.nlm.nih.gov] In the clinical neurological examination, there was a facial but no limb muscle weakness or atrophy. Ankle jerks were weak. [bmcresnotes.biomedcentral.com] […] muscle weakness as well as a bilateral winged scapula associated with atrophy of the pectoralis major muscle and lumbar lordosis; pelvic muscles were mostly spared. [ncbi.nlm.nih.gov] Nemaline Myopathy Type 4 Six patients were classified as of childhood onset type, with lower-limb weakness and progressive course. [spandidos-publications.com] neck, and limbs. [malacards.org] Symptoms such as lower limb weakness, dyspnea and myalgia developed rapidly in 7 cases during adulthood. [spandidos-publications.com] Spinal Muscular Atrophy As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles. [cedars-sinai.edu] In addition to muscle weakness, clinical features include head lag, poor sucking and swallowing, weak cry, proximal limb weakness, and lack of reflexes. [encyclopedia.com] Limb girdle weakness, twitching, lack of reflexes, and weakness of tongue, face, and neck muscles are seen. [encyclopedia.com]
