Limb Weakness: Causes & Reasons

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Possible Causes for Limb Weakness

Multifocal Motor Neuropathy

The initial high-dose intravenous immunoglobulin treatment significantly improved left upper limb muscle weakness. [ncbi.nlm.nih.gov]

Multifocal motor neuropathy (MMN) is typically associated with distal upper limb weakness and wasting. [ncbi.nlm.nih.gov]

Multifocal motor neuropathy is a disorder characterized by slowly progressive asymmetrical limb weakness and multiple motor conduction blocks. [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy

PATIENT CONCERNS: A 25-year-old woman was admitted to our department as the limb weakness progressively worsened. [ncbi.nlm.nih.gov]

Limb-girdle muscular dystrophies (LGMD) are a group of clinically and genetically heterogeneous diseases characterized by weakness and wasting of the pelvic and shoulder girdle [ncbi.nlm.nih.gov]

A 40-year-old woman reported exercise-induced calf pain at age 34, followed by progressive lower and upper limb weakness. [ncbi.nlm.nih.gov]

Chronic Inflammatory Demyelinating Polyneuropathy

We described a young girl with CIDP underlying type 2 diabetes mellitus, presenting with progressive numbness and limb weakness, who was initially misdiagnosed to have DPN [ncbi.nlm.nih.gov]

Although at 25 years of age she had already been diagnosed with limb weakness associated with chronic inflammatory demyelinating polyneuropathy (CIDP), she had never experienced [ncbi.nlm.nih.gov]

Proximal limb weakness is a core feature of CIDP, differentiating this disorder from other neuropathies, which often involve more distal portion of limbs. [symptoma.com]

Erb Muscular Dystrophy

In 1954, when Walton and Nattrass reported 105 cases of limb-girdle weakness associated with many other disorders, the nosologic entity of limb-girdle dystrophy was formally [emedicine.medscape.com]

The weakness slowly gets worse, and people may need the aid of a cane or a walker. [icdlist.com]

Affected individuals develop weakness of the lower limbs that may be mild or severe. Weakness of facial muscles may also occur. [rarediseases.org]

Myopathy

A 47-year-old man with liver cirrhosis developed limb weakness after liver transplantation. [ncbi.nlm.nih.gov]

Background Immune-mediated necrotising myopathies are characterised clinically by the subacute onset of proximal limb weakness, accompanied by elevated creatinine kinase levels [ncbi.nlm.nih.gov]

Patients present with axial hypotonia, myopathic facies with fatigable ptosis, feeding difficulties, delayed gross motor development and proximal limb weakness with a RYR1 [orpha.net]

Lambert-Eaton Syndrome

Neurological examination revealed muscle weakness, predominantly in the proximal parts of the limbs. [ncbi.nlm.nih.gov]

Here, we describe a patient with a 5-year history of cervical myelopathy who presented with recurrent limb weakness of her limbs and complained of recent progressive weakness [ncbi.nlm.nih.gov]

[…] muscle weakness), or limb muscle weakness. [jnnp.bmj.com]

Nemaline Myopathy Type 4

Six patients were classified as of childhood onset type, with lower-limb weakness and progressive course. [spandidos-publications.com]

neck, and limbs. [malacards.org]

Symptoms such as lower limb weakness, dyspnea and myalgia developed rapidly in 7 cases during adulthood. [spandidos-publications.com]

Diabetic Amyotrophy

BACKGROUND: People with diabetes mellitus (DM) sometimes present with acute or subacute, progressive, asymmetrical pain and weakness of the proximal lower limb muscles. [ncbi.nlm.nih.gov]

[…] involving predominantly the proximal muscles of the lower limbs; weakness that is not confined to one nerve or nerve root distribution; and exclusion of other causes of lumbosacral [ncbi.nlm.nih.gov]

[…] involving predominantly the proximal muscles of the lower limbs, weakness that is not confined to one nerve or nerve root distribution and exclusion of other causes of lumbosacral [ncbi.nlm.nih.gov]

Adult Spinal Muscular Atrophy

As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles. [cedars-sinai.edu]

weakness, hypotonia Bulbar palsy Late Microcephaly Oculomotor defects: strabismus, nystagmus, oculomotor apraxia Cognitive defects Life expectancy < 1 year Diagnostics Genetic [amboss.com]

In addition to muscle weakness, clinical features include head lag, poor sucking and swallowing, weak cry, proximal limb weakness, and lack of reflexes. [encyclopedia.com]

Peripheral Motor Neuropathy

weakness in individual motor nerve distribution with or without persistent conduction block preferentially affecting young man. [neurology.org]

[…] eruption and the development of limb weakness may vary from 1 day to 4 months. [2] In all our three cases, limb paralysis developed 2-3 weeks after the onset of skin lesions [ijdvl.com]

weakness and areflexia Minimal sensory loss Axonal destruction Subacute Diabetic Proximal Neuropathy Proximal muscle weakness associated with reduced or absent lower extremity [enotes.tripod.com]

Amyotrophic Lateral Sclerosis Type 4

[…] lateral sclerosis type 4 Disease definition A rare, genetic motor neuron disease characterized by late childhood- or adolescent-onset of slowly progressive, severe, distal limb [orpha.net]

Among patients with ALS, fasciculation frequency is not associated with the duration of ALS and is independent of the degree of limb weakness and limb atrophy. [en.wikipedia.org]

Although most patients had upper (90%) and lower (92%) limb weakness on examination, lower limb weakness was usually more severe (Table 1 ). [academic.oup.com]

Autosomal Recessive Spastic Paraplegia Type 46

[…] muscle weakness Lower extremity weakness Lower limb weakness Muscle weakness in lower limbs [ more ] 0007340 Spastic paraplegia 0001258 30%-79% of people have these symptoms [rarediseases.info.nih.gov]

limbs. [publikationen.uni-tuebingen.de]

Systemic Features: Stiffness and weakness of the lower limbs begins between 2 and 20 years of age. [disorders.eyes.arizona.edu]

MERRF Syndrome

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) Onset: Usually before age 20 Symptoms: This disorder causes PEO, ptosis (droopy eyelids), limb weakness and gastrointestinal [mda.org]

The patient had approximately 10 attacks per day, which were accompanied by limb weakness. [spandidos-publications.com]

Exercise intolerance, limb weakness, hearing loss, and diabetes may also precede the occurrence of the stroke-like episodes. [umdf.org]

Amyotrophic Lateral Sclerosis Type 9

[…] of limbs (60-80%), bulbar symptoms (20%), respiratory muscle weakness (1-3%), generalized weakness in limbs and bulbar muscles (1-9%), axial onset with muscle weakness, muscle [nnjournal.net]

ALS damages the corticospinal tract and causes spastic limb weakness. The anterior horn is the front part of the spinal cord. [healthline.com]

There was distal motor weakness in the lower limbs graded 3. [jamanetwork.com]

Facioscapulohumeral Muscular Dystrophy

FSHD presentation with foot drop or lower limb proximal weakness appeared to be more frequent than expected. [ncbi.nlm.nih.gov]

[…] distal (22.45 %) or proximal lower limb weakness (14.8 %). 85.57 % patients were ambulant or ambulant with assistance at the time of registration, 7.9 % report respiratory [ncbi.nlm.nih.gov]

The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing [kennedykrieger.org]

Motor Neuron Disease

Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients [ncbi.nlm.nih.gov]

Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb. [patient.info]

He developed gait disturbance and weakness of lower limbs at age 52 years. Because of progressive muscle weakness and atrophy, he became bed-ridden at age 65. [ncbi.nlm.nih.gov]

Spinal Cord Compression

We report a 7-year-3-month-old girl who suffered from neck pain with restricted movement, poor appetite, body weight loss, mild right limbs weakness, and a non-tender neck [ncbi.nlm.nih.gov]

We present the case of a 33-year-old Caucasian woman with a 10-day history of thoracic back pain and a 1-day history of sudden-onset bilateral lower limb weakness and paresthesia [ncbi.nlm.nih.gov]

We report neurologic improvements, no sphincter disorder, persistent spasticity, and lower limbs weakness not affecting full ambulation. [ncbi.nlm.nih.gov]

Acute Hepatic Porphyria

weakness or pain, anxiety, confusion, and skin lesions on sun-exposed areas (HCP and VP only). [thinkporphyria.eu]

weakness or pain Numbness Fatigue Tiredness Paralysis Respiratory paralysis Sensory loss 3CARDIOVASCULAR Rapid heart rate High blood pressure 4CUTANEOUS (SKIN) SYMPTOMS* [porphyria.com]

People with AHP should also learn the signs of an imminent attack — some people, for example, may feel anxious or confused, while others may experience limb weakness, fatigue [healthywomen.org]

Muscular Dystrophy

Later on, after many years, mild limb weakness around the shoulders and hips may also develop. [patient.info]

[…] about Duchenne muscular dystrophy Facioscapulohumeral Muscular Dystrophy: Facioscapulohumeral (FSH) dystrophy is a common muscular dystrophy in which there is progressive weakness [kennedykrieger.org]

Polymyositis

In her history, she had upper and lower limbs weakness accompanied by dysphagia which was further complicated by right bronchial aspiration 9 months ago. [ncbi.nlm.nih.gov]

Examination revealed multiple telangiactasia over face and nail beds and bilateral proximal lower limb weakness of power 4/5. [ncbi.nlm.nih.gov]

Tarimas: /ˌpɒlɪmʌɪə(ʊ)ˈsʌɪtɪs/ polymyositis lietuviškai polimiozitas Paaiškinimas anglų kalba myositis characterized by weakness of limb and neck muscles and much muscle pain [angluzodynas.lt]

Spinal Muscular Atrophy Type 3

weakness that resembled muscular dystrophy, but the muscle biopsy and EMG indicated neuronal disease. [jkna.org]

As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles. [cedars-sinai.edu]

limbs appearing limp and floppy Breathing problems caused by weakness in the baby’s chest Some children also develop scoliosis (exaggerated curvature of the spine) Most [thehumanthebody.com]

Spinal Muscular Atrophy Type 1

As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles. [cedars-sinai.edu]

Symptoms include tremors of the hands, muscle cramps, limb weakness, and twitching. [healthline.com]

Symptoms include floppy limbs and weak trunk movement. Children with this type usually have very limited ability to move. [my.clevelandclinic.org]

Spinal Paralytic Poliomyelitis

Also, cases of focal limb weakness or paralysis have been identified after infection with enterovirus D68. [merckmanuals.com]

Your doctor may suspect that you have polio if you have fever with limb weakness or paralysis that mainly affects one side of your body. [drugs.com]

Weakness is asymmetric, with the lower limbs affected more than upper limbs. Muscle tone is flaccid, and the reflexes initially are brisk but then become absent. [sites.google.com]

Hereditary ATTR Amyloidosis

weakness and pain Autonomic neuropathy – Light-headedness when standing (orthostatic hypotension), bladder problems, bowel problems, sexual dysfunction Gastrointestinal – [amyloidosis-austria.at]

Symptoms of hereditary ATTR amyloidosis Symptoms of hereditary ATTR amyloidosis may include: Peripheral neuropathy: limb weakness and pain, loss of sensation. [abdalihospital.com]

Symptoms Symptoms may include: peripheral neuropathy: limb weakness and pain, loss of sensation autonomic neuropathy: disturbances of bowel, bladder and blood pressure and [ttramyloidosis.uk]

Mononeuritis Multiplex

weakness from mononeuritis multiplex. ( 27728172 ) 2016 19 Mononeuritis multiplex in acquired amegakaryocytic thrombocytopenia. ( 26752909 ) Khan F....Mukundan L. 2015 20 [malacards.org]

weakness from mononeuritis multiplex. ( 27728172 ) Kadhiravan. 2016 19 Cranial mononeuritis multiplex as the initial manifestation of systemic lupus erythematosus: A diagnostic [malacards.org]

We report a 42 year-old female who presented with severe lower limb neuropathic pain, asymmetric weakness and sensory impairment and was diagnosed with mononeuritis multiplex [ncbi.nlm.nih.gov]

Brachial Plexus Neuropathy

Fourteen days post-transplant he developed rapidly progressive proximal weakness in both upper limbs. [nature.com]

The disease was characterized by repeated attacks of pain in the upper limb/shoulder region, followed by muscle weakness and atrophy. [ncbi.nlm.nih.gov]

Improvement of measured indexes: pain assessment, centimetry, assessment of upper limb muscle weakness, dynamometry and functional test of activities of daily living, was [degruyter.com]

Poliomyelitis

[…] and generalized limb weakness in the other patient, reaching a nadir in 1 week. [ncbi.nlm.nih.gov]

CLINICAL PICTURE AND INVESTIGATION: A 57-year-old Chinese man with a history of poliomyelitis affecting both lower limbs presented with left upper limb weakness. [ncbi.nlm.nih.gov]

weakness for past two years. [ncbi.nlm.nih.gov]

Primary CD59 Deficiency

[…] muscle weakness, and hyporeflexia. [malacards.org]

[…] polyneuropathy is an autosomal recessive disorder characterized by infantile onset of a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifest as hypotonia, limb [malacards.org]

[…] recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb [malacards.org]

Lumbosacral Plexus Disorder

weakness. [neupsykey.com]

After infections, surgery or stress Few episodes after 50 years Non-penetrance: Rare Pain Precedes weakness Increased by limb movement Weakness: Multifocal Course: Maximum [neuromuscular.wustl.edu]

Limb-girdle muscular dystrophy This is a heterogeneous group of conditions that usually appear in adolescence or adult life with proximal limb weakness. [dartmouth.edu]

Pompe Disease

There may be limb-girdle weakness and weakness of respiratory muscles.[5] Signs Infantile form: Cardiomegaly and congestive heart failure. [patient.info]

The glycogen accumulation leads to myopathy / progressive muscle weakness, notably limb-girdle muscle weakness. [youtube.com]

weakness respiratory issues Enzyme replacement therapy alglucosidase alfa Cori disease (type III) Glycogen debranching enzyme Autosomal recessive Most cases involve the muscle [medbullets.com]