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3,257 Possible Causes for Limb Weakness, Muscle Biopsy showing Variation In Fiber Size, Onset between 6 and 14 Years

  • Limb-Girdle Muscular Dystrophy

    Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[dnatesting.uchicago.edu] Early motor milestones: Most normal; Toe walking common Range: 2 to 45 years; Median 14 to 20 years; 71% between 6 to 18 years Weakness: Proximal legs; Rectus abdominus No[neuromuscular.wustl.edu] Limb-girdle muscular dystrophies (LGMD) are a group of clinically and genetically heterogeneous diseases characterized by weakness and wasting of the pelvic and shoulder girdle[ncbi.nlm.nih.gov]

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing[kennedykrieger.org] variation in muscle fiber size not segregated by motor unit.[merckmanuals.com]

    Missing: Onset between 6 and 14 Years
  • Duchenne Muscular Dystrophy

    And 2) are these gait deviations related to lower limb weakness?[ncbi.nlm.nih.gov] Abstract Duchenne muscular dystrophy (DMD) is an X-linked form of muscular dystrophy characterized by progressive limb-girdle distribution of muscle weakness.[ncbi.nlm.nih.gov] DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness.[medterms.com]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2B

    EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[checkorphan.org] A 25-year-old woman was admitted to our department as the limb weakness progressively worsened.[ncbi.nlm.nih.gov] […] muscle weakness Lower extremity weakness Lower limb weakness Muscle weakness in lower limbs [ more ] 0007340 Muscular dystrophy 0003560 Pectoralis amyotrophy Wasting of pec[rarediseases.info.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2G

    After 20 years old, he noticed progressive gait disturbance with weakness in the lower limbs and tremor on the hands.[bmcclinpathol.biomedcentral.com] […] muscular dystrophy characterized by a variable onset (ranging from infancy to adolescence) of progressive proximal upper and lower limb muscle weakness and atrophy.[malacards.org] ) of progressive proximal upper and lower limb muscle weakness and atrophy.[rarediseases.info.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Distal Myopathy Type 3

    Figure 2 Immunohistochemistry, immunoblotting and molecular genetic analysis. ( A ) Micrograph of the muscle biopsy of the right gastrocnemius muscle showing markedly increased[jmedicalcasereports.biomedcentral.com] Age of onset of initial symptoms varied between patients: In family A (Fig. 1A ), while patient 6 was symptomatic already at 2 years of age, patients 1, 5 and 7 recall initial[bmcmedgenet.biomedcentral.com] Welander distal myopathy (WDM) is a late adult-onset autosomal dominant disorder, characterized by a slow progression and distal limb weakness of the extremity muscles.[dx.doi.org]

  • Rigid Spine Syndrome

    Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[cags.org.ae] .  Onset is at birth or in early childhood  Nonprogressive limb weakness, mild facial weakness, and hypotonia.  Skeletal abnormalities include congenital hip dislocation[slideshare.net] In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[ncbi.nlm.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Facioscapulohumeral Muscular Dystrophy

    Muscle biopsy showed increased variation in fiber size and multifocal degenerating fibers with lymphocytic infiltration.[ncbi.nlm.nih.gov] FSHD presentation with foot drop or lower limb proximal weakness appeared to be more frequent than expected.[ncbi.nlm.nih.gov] […] distal (22.45 %) or proximal lower limb weakness (14.8 %). 85.57 % patients were ambulant or ambulant with assistance at the time of registration, 7.9 % report respiratory[ncbi.nlm.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Congenital Merosin-Positive Muscular Dystrophy

    (Top) Muscle biopsy showing variation in muscle fiber size with atrophic and hypertrophic fibers.[myslide.es] May need nasogastric tube, limb weakness and elevated serum creatine kinase. (11)Fukuyama CMD – -in western countries this type of CMD is rare but is common in Japan.[mobilephysiotherapyclinic.in] May need nasogastric tube, limb weakness and elevated serum creatine kinase.[ipfs.io]

    Missing: Onset between 6 and 14 Years
  • Multicore Myopathy with External Ophthalmoplegia

    […] mild truncal andproximal limb weakness.[docslide.com.br] .  Onset is at birth or in early childhood  Nonprogressive limb weakness, mild facial weakness, and hypotonia.  Skeletal abnormalities include congenital hip dislocation[slideshare.net] BACKGROUND: A 13.5-year-old girl presented with congenital-onset facial and neck weakness, slowly progressive severe limb girdle and axial myopathy, respiratory weakness,[ncbi.nlm.nih.gov]

    Missing: Onset between 6 and 14 Years

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