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108 Possible Causes for Limb Weakness, Rapid Progression to Disability

  • Primary Progressive Multiple Sclerosis

    Although progression is more rapid, age-related disability milestones are identical to relapsing-onset disease.[ncbi.nlm.nih.gov] Symptoms can include: Pain (for example, headaches, pain in the legs and feet, back pain, and muscle spasms) Electric-shock sensations that run down the back and limbs when[hopkinsmedicine.org] Typical symptoms associated with PML are diverse, progress over days to weeks, and include progressive weakness on one side of the body or clumsiness of limbs, disturbance[ocrevus.com]

  • Muscular Dystrophy

    It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing[kennedykrieger.org] Disease progression is typically very slow, with intermittent spurts of rapid muscle deterioration.[web.archive.org]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Compared with patients with MADSAM, patients with typical CIDP showed more rapid progression and severe disability, and demyelination predominant in the distal nerve segments[ncbi.nlm.nih.gov] We described a young girl with CIDP underlying type 2 diabetes mellitus, presenting with progressive numbness and limb weakness, who was initially misdiagnosed to have DPN[ncbi.nlm.nih.gov] Although at 25 years of age she had already been diagnosed with limb weakness associated with chronic inflammatory demyelinating polyneuropathy (CIDP), she had never experienced[ncbi.nlm.nih.gov]

  • Duchenne Muscular Dystrophy

    Disease progression is typically very slow, with intermittent spurts of rapid muscle deterioration.[web.archive.org] And 2) are these gait deviations related to lower limb weakness?[ncbi.nlm.nih.gov] Abstract Duchenne muscular dystrophy (DMD) is an X-linked form of muscular dystrophy characterized by progressive limb-girdle distribution of muscle weakness.[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy

    It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] Limb-girdle muscular dystrophies (LGMD) are a group of clinically and genetically heterogeneous diseases characterized by weakness and wasting of the pelvic and shoulder girdle[ncbi.nlm.nih.gov] PATIENT CONCERNS: A 25-year-old woman was admitted to our department as the limb weakness progressively worsened.[ncbi.nlm.nih.gov]

  • Multiple Sclerosis

    progression of disability, more frequent relapses, and worse postrelapse recoveries.[dx.doi.org] Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination,[ncbi.nlm.nih.gov] Cochrane Database of Systematic Reviews Background Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration[doi.org]

  • Erb Muscular Dystrophy

    It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] Symptoms - Muscular dystrophy limb girdle type 2A- Erb type Muscle weakness is first evident in the shoulder girdle and later in the pelvic girdle.[checkorphan.org] In 1954, when Walton and Nattrass reported 105 cases of limb-girdle weakness associated with many other disorders, the nosologic entity of limb-girdle dystrophy was formally[emedicine.medscape.com]

  • Myopathy

    disability.[jnnp.bmj.com] A 47-year-old man with liver cirrhosis developed limb weakness after liver transplantation.[ncbi.nlm.nih.gov] Background Immune-mediated necrotising myopathies are characterised clinically by the subacute onset of proximal limb weakness, accompanied by elevated creatinine kinase levels[ncbi.nlm.nih.gov]

  • Facioscapulohumeral Muscular Dystrophy

    However, evidence suggests that the disease course is most frequently characterized by slow progression with short periods of rapid muscle deterioration.[rarediseases.org] FSHD presentation with foot drop or lower limb proximal weakness appeared to be more frequent than expected.[ncbi.nlm.nih.gov] It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com]

  • Lambert Eaton Myasthenic Syndrome

    progression to severe disability and the absence of regeneration in a sural nerve biopsy.[doi.org] Here, we describe a patient with a 5-year history of cervical myelopathy who presented with recurrent limb weakness of her limbs and complained of recent progressive weakness[ncbi.nlm.nih.gov] Neurological examination revealed muscle weakness, predominantly in the proximal parts of the limbs.[ncbi.nlm.nih.gov]

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