nigra, palmar erythema, varicose veins, striae, spider angiomas,hirsutism, pyogenic granuloma Psoriasis-like skin and mucous membrane lesions, keratoderma blennorrhagicum
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dystrophic, brittle toenails; cool skin; hairless shins; ulcers; pallor; cyanosis; gangrene Pregnancy (physiologic changes) Melasma, increased pigmentation of areolae, linea
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