Lip Blisters: Possible Causes & Differential Diagnoses

Stevens-Johnson Syndrome
Cracked Lips Lip Blisters

Steven-Johnson Syndrome (SJS) is a severe allergic cutaneous disorder. This skin disorder is often brought about by the intake of common drugs like sulfa drugs, anti-convulsants, and antibiotics. The syndrome is characterized by generalized macular lesions that rapidly spread and consolidate leading to epidermal…^[1]
Methotrexate
Lip Blisters
Brandt Syndrome
Lip Blisters

Brandt syndrome (BS) is also called acrodermatitis enteropathica (AE). It is a congenital disease that causes zinc deficiency due to malabsorption. Inherited in an autosomal recessive pattern, BS characteristically presents with dermatitis, diarrhea and hair loss. Brandt syndrome (BS) is an autosomal recessive inborn…^[2]
Herpes Labialis
Lip Blisters

Herpes simplex labialis (orolabial herpes or cold sores) is a viral infection which occurs on the lips or around the mouth. It affects people worldwide. The primary causative agent is HSV-1. Prodromal symptoms of primary herpes labialis: Fever Sore throat and mouth Submandibular or cervical lymphadenopathy…^[3]
Plasma Cell Gingivitis
Lip Blisters

Plasma cell gingivitis (PCG) is a rare inflammatory disease of the gums, which is defined by plasma cell infiltration into subepithelial tissue. This benign condition is characterized by gingival erythema and edema. Although the etiology may be unknown, this is believed to be a hypersensitivity reaction in some cases. The…^[4]
Insect Bite
Lip Swelling

Insect bites may be inflicted by mosquitos, fleas, bugs, lice and a plethora of other species pertaining to distinct families of the order insects. While they are of little medical interest in the vast majority of cases, immunocompromised or allergic patients may suffer from severe reactions to an insect bite. Most…^[5]
Myxedema
Lip Edema Lip Swelling

Myxedema or severe hypothyroidism is clinical condition where the thyroid gland does not produce any thyroid hormone. In some cases, myxedema condition is also being referred to as underactive thyroid. Myxedema typically present with a distinct facial appearance, hoarse slow speech, and dryness of the skin. The…^[6]
Hypersensitivity
Lip Swelling

An allergy is defined as an immune response induced by exposure to an allergen. Austrian pediatrician Clemens Pirquet first used the term allergy in 1906. Hypersensitivity reactions can be divided into four groups: type I, type II, type III and type IV, based on the mechanisms involved. Symptoms of type1…^[7]
Herpes Zoster
Lip Swelling

Herpes zoster is a condition characterized by development of skin rash with blisters. It is a viral disease that promotes development of rash only on one side of the body. Pain is the preliminary sign of herpes zoster. Few days later, skin rashes develop only on one side of the body affecting one or more skin…^[8]
Angioedema
Lip Edema Lip Swelling

Angioedema is the swelling of skin, subcutaneous, or submucosal tissue due to acquired or genetic causes. In hereditary angioedema, the patients present with swelling that develops 2 to 5 hours after any stimulus such as a minor trauma or infection. The swelling can involve any part of body and is often associated…^[9]

Possible Causes for Lip Blisters in USA

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References