Lip Swelling: Possible Causes & Differential Diagnoses

Insect Bite
Lip Swelling

Insect bites may be inflicted by mosquitos, fleas, bugs, lice and a plethora of other species pertaining to distinct families of the order insects. While they are of little medical interest in the vast majority of cases, immunocompromised or allergic patients may suffer from severe reactions to an insect bite. Most…^[1]
Cheilitis
Cracked Lips Lip Swelling

Cheilitis granulomatosa: The onset of symptoms is an on-and-off upper lip swelling resembling angioedema.^[2]
Myxedema
Lip Swelling

Myxedema or severe hypothyroidism is clinical condition where the thyroid gland does not produce any thyroid hormone. In some cases, myxedema condition is also being referred to as underactive thyroid. Myxedema typically present with a distinct facial appearance, hoarse slow speech, and dryness of the skin. The…^[3]
Hypersensitivity
Lip Swelling

An allergy is defined as an immune response induced by exposure to an allergen. Austrian pediatrician Clemens Pirquet first used the term allergy in 1906. Hypersensitivity reactions can be divided into four groups: type I, type II, type III and type IV, based on the mechanisms involved. Symptoms of type1…^[4]
Herpes Zoster
Lip Swelling

Herpes zoster is a condition characterized by development of skin rash with blisters. It is a viral disease that promotes development of rash only on one side of the body. Pain is the preliminary sign of herpes zoster. Few days later, skin rashes develop only on one side of the body affecting one or more skin…^[5]
Melkersson-Rosenthal Syndrome
Lip Swelling

Melkersson-Rosenthal syndrome (MRS) is a rare genetic condition characterized by recurrent nonpitting orofacial edema, especially of one or both lips (granulomatous cheilitis), lower motoneuron facial paralysis and fissured dorsal tongue (lingua plicata). It is inherited in an autosomal dominant pattern and may have…^[6]
Angioedema
Swelling Leg Swelling Lip Swelling

Angioedema is the swelling of skin, subcutaneous, or submucosal tissue due to acquired or genetic causes. In hereditary angioedema, the patients present with swelling that develops 2 to 5 hours after any stimulus such as a minor trauma or infection. The swelling can involve any part of body and is often associated…^[7]
Periapical Abscess
Lip Swelling

Periapical abscess occurs as a result of bacterial infection of the tooth and the surrounding structures, most commonly on the grounds of dental caries and tooth decay. Focal inflammation and abscesses can produce intense pain, and the diagnosis can be achieved through physical examination. Treatment includes…^[8]
Hereditary Angioedema Type 2
Swelling Leg Swelling Lip Swelling

Hereditary angioedema type II is a genetic disorder in which synthesis of dysfunctional C1-esterase inhibitor results in angioedema, abdominal pain, and erythema marginatum. The clinical presentation is identical to HAE type 1. Angioedema, defined as sudden onset of edema involving the subcutaneous tissues of the…^[9]
Anaphylaxis
Lip Swelling

Anaphylaxis is a rapidly progressing, life-threatening allergic reaction. The symptoms of anaphylaxis usually occur within minutes of exposure to an allergen. Symptoms usually vary in severity. Sometimes they only cause mild itching or swelling, but in some people they can be severe and life threatening. The symptoms of…^[10]

Possible Causes for Lip Swelling in USA

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References