Lip Thickening: Causes & Reasons

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Possible Causes for Lip Thickening

Mucopolysaccharidosis

A distinctive facies with thickening of lips and nostrils as well as an enlarged and protruding tongue forms slowly and may become evident between 2-4 years of age, later [orpha.net]

Increased accumulation of mucopolysaccharides leads to characteristic facial features such as thickened lips, enlarged tongue, a full lower aspect of the face, depressed nasal [invitae.com]

Increased volume of lip Plump lips Prominent lips Thick lips [ more ] 0012471 Thickened skin Thick skin 0001072 Tracheal stenosis Narrowing of windpipe 0002777 Umbilical [rarediseases.info.nih.gov]

Mucopolysaccharidosis Type 6

[symptoma.com] Such characteristics include chubby faces, thickened lips due to the overgrowth of the gums ( gingival hypertrophy ), an unusually prominent forehead (frontal [symptoma.com]

Such characteristics include chubby faces, thickened lips due to the overgrowth of the gums (gingival hypertrophy), an unusually prominent forehead (frontal bossing), and [rarediseases.org]

Clinical manifestations Upper airways Facial coarseness, hypertelorism, sunken nasal dorsum, anteverted nostrils, thickened lips, gingival hyperplasia [19] and dental distortions [hindawi.com]

Multiple Endocrine Neoplasia Type 2B

Prominent physical features include full lips, thickened eyelids, high arched palate and a marfanoid habitus. [disorders.eyes.arizona.edu]

Most affected individuals have characteristic physical features, including full lips, thickened eyelids, high-arched palate, and marfanoid habitus. [diseaseinfosearch.org]

The thickening of the lips and eyelids are secondary to the mucosal neuromas. [webeye.ophth.uiowa.edu]

Multiple Endocrine Neoplasia

Prominent physical features include full lips, thickened eyelids, high arched palate and a marfanoid habitus. [disorders.eyes.arizona.edu]

The thickening of the lips and eyelids are secondary to the mucosal neuromas. [eyerounds.org]

Neuromas often lead to thickening of the lips and tongue and can also appear as pedunculated nodules on these structures. [disorders.eyes.arizona.edu]

Gigantism - Acromegaly

This leads to a characteristic appearance of the lower jaw and lips, thickening of the fingers and feet, and enlargement of cartilage structures, such as the nose and adams [tallclub.co.uk]

Other symptoms, like increasingly apparent facial features (thickened lips and protruding brows, for example), don’t appear until the diseases have progressed. [medicaldaily.com]

Definition (NCI) A syndrome characterized by enlargement of the hands, feet, ears, nose, lips, and tongue, skin thickening and swelling of internal organs. [fpnotebook.com]

Double Outlet Right Ventricle

[…] may include: Enlarged heart Heart murmur Rapid breathing Rapid heartbeat Symptoms of DORV may include: Poor feeding from becoming tired easily Bluish color of the skin and lips [nlm.nih.gov]

Babies who have DORV may show these symptoms: Tiring easily, especially when feeding Bluish color of the skin and lips Clubbing (thickening of the nail beds) of the fingers [fetaltonewborn.org]

Clubbing (thickening of the nail beds) on toes and fingers (late sign) Failure to gain weight and grow Pale coloring Sweating Swollen legs or abdomen Trouble breathing Exams [indiatoday.intoday.in]

Ectopic Acromegaly

Clinical findings Coarsened, enlarged facies, lips, tongue, nose, jaw, hands, feet, supraorbital ridge and frontal bones, widely spaced teeth, bone proliferation in extremities [medical-dictionary.thefreedictionary.com]

The nose is widened and thickened, the cheekbones are obvious, the forehead bulges, the lips are thick and the facial lines are marked. [ncbi.nlm.nih.gov]

soft tissue thickening, hyperhidrosis, macroglossia, headache, amenorrhoea, impotence, somnolence, moodiness, glucose intolerance, cardiomegaly with heart failure (acromegalic [medical-dictionary.thefreedictionary.com]

X-linked Mental Retardation Type Cabezas

[…] vermilion Plump lower lip Increased volume of lower lip Prominent lower lip [ more ] 0000179 Tremor 0001337 5%-29% of people have these symptoms Acanthosis nigricans Darkened [rarediseases.info.nih.gov]

[…] and thickened skin 0000956 Biparietal narrowing 0004422 Brachydactyly Short fingers or toes 0001156 Camptodactyly of finger Permanent flexion of the finger 0100490 Cerebellar [rarediseases.info.nih.gov]

[…] second toe [ more ] 0001852 Scoliosis 0002650 Short foot Short feet Small feet [ more ] 0001773 Short stature Decreased body height Small stature [ more ] 0004322 Thick lower lip [rarediseases.info.nih.gov]

X-Linked Syndromic Mental Retardation Type Snyder-Robinson

[…] lower lip, nasal dysarthic speech, narrow or cleft palate, osteoporosis, kyphoscoliosis, long great toes, short stature, pectus carinatum, and myopia that has_material_basis_in [informatics.jax.org]

[…] lower lip, nasal dysarthic speech, narrow or cleft palate, diminished muscle mass, osteoporosis, kyphoscoliosis, long great toes, short stature, pectus carinatum, and myopia [malacards.org]

Symptoms and phenotype MRXSSR is an X-linked intellectual disability syndrome with characteristic features including facial asymmetry, marfanoid habitus, unsteady gait, thickened [flybase.org]

Double Outlet Left Ventricle

Babies who have DORV may show these symptoms: Tiring easily, especially when feeding Bluish color of the skin and lips Clubbing (thickening of the nail beds) of the fingers [fetaltonewborn.org]

[…] may include: Enlarged heart Heart murmur Rapid breathing Rapid heartbeat Symptoms of DORV may include: Poor feeding from becoming tired easily Bluish color of the skin and lips [medlineplus.gov]

[…] great arteries (the aorta and pulmonary artery are switched) Symptoms Symptoms of DORV may include: Poor feeding from becoming tired easily Bluish color of the skin and lips [ufhealth.org]

Mucopolysaccharidosis Type 2

A distinctive facies with thickening of lips and nostrils as well as an enlarged and protruding tongue forms slowly and may become evident between 2-4 years of age, later [orpha.net]

Signs and symptoms include claw-like hands, protruding tongue, changing facial features, including thickening of the lips, tongue and nostrils and delayed development. [businesswire.com]

Acromegaly

Lip thickening is obvious in acromegaly. [frontiersin.org]

[…] accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue thickened ribs (creating a barrel chest) joint pain degenerative arthritis enlarged [hopkinsmedicine.org]

The co-existence of lower lip ectropion and lip thickening made the 3D image measurement of the lower lip (vermilion) larger than the actual size and led to the phenomenon [frontiersin.org]

Autosomal Dominant Prognathism

Association with mildly everted lower eyelids, flat malar area, thickened lower lip and craniosynostosis has been reported. [orpha.net]

lips (without a true ’double lip’), overgrowth of the intraoral mucosa resulting in exaggerated rugae and frenula, and thickened upper eyelids leading to narrow palpebral [e-kjgm.org]

Xq26 300037 Simpson dysmorphia syndrome 312870 X disproportionately large head, coarse facies, large protruding jaw, wide nasal bridge, upturned nasal tip, large mouth, thickened [en.wikibooks.org]

Carcinoma of the Oral Cavity

Other symptoms include: A sore on the lip that doesn't heal Persistent lip pain or lip numbness A lump or thickening on the lip A white or red patch on the lip A neck mass [cancercenter.com]

A sore or irritation that doesn't go away Red or white patches Pain, tenderness or numbness in mouth or lips A lump, thickening, rough spot, crust or small eroded area Difficulty [mouthhealthy.org]

Miller-Dieker Syndrome

[…] upper lip with a thin vermilion upper border, widely spaced eyes, low ears, and small jaw. [medicinenet.com]

The upper lip is thickened, but with a thin vermillion border. There is an elongated philtrum with rounded pillars. [doi.org]

[…] characterized by lissencephaly ("smooth brain") and a characteristic facial appearance with a prominent forehead with bitemporal hollowing, short nose with upturned nares, thickened [medicinenet.com]

Cheilitis

The patient reported that the skin over the lip thickened gradually over a 3-day period and subsequently became loose, causing discomfort. [cjhr.org]

The skin of the lip thickens due to this disorder and the red junction of the skin and the lip suffers a whitish discoloration. [primehealthchannel.com]

Actinic cheilitis presents as diffuse or patchy dryness and variable thickening of the vermilion of the lower lip. [dermnetnz.org]

Lipoid Proteinosis

On clinical examination there was hoarseness of voice, oral mucosa was thickened with slightly yellowish tinge, tongue was thickened, firm and with restricted mobility, lips [e-ijd.org]

The tongue, lips, and frenulum were thickened and infiltrated, and the patients were unable to protrude the tongue out of the mouth. The scalp had patchy alopecia. [ncbi.nlm.nih.gov]

Often, gingival hypertrophy with irregularly thickened lips is found. [13] Lingual frenulum may be thickened restricting the tongue movements during deglutition and speech [contempclindent.org]

Taussig Bing Anomaly

[…] great arteries (the aorta and pulmonary artery are switched) Symptoms Symptoms of DORV may include: Poor feeding from becoming tired easily Bluish color of the skin and lips [ufhealth.org]

Clubbing (thickening of the nail beds) of toes and fingers (late sign) Failure to gain weight and grow Pale coloring Sweating Swollen legs or abdomen Trouble breathing Treatment [medlineplus.gov]

Mucopolysaccharidosis Type 4

Characterised by full lips, thickening of alar nasi, ear lobes and skull bones. Dysostosis multiplex : progressive skeletal dysplasia. [genetics4medics.com]

The oral findings included thickened lips, prominent rugae, macroglossia, mouth breathing, tongue thrusting, and anterior open bite. [jisppd.com]

Increased accumulation of mucopolysaccharides leads to characteristic facial features such as thickened lips, enlarged tongue, a full lower aspect of the face, depressed nasal [invitae.com]

Geleophysic Dysplasia Type 2

Figure 2 - Patients 1 and 2: Ocular hypertelorism, small nose, thickened upper lip with long and flat philtrum, and pectus excavatum. [scielo.br]

Clinical description The characteristic facial appearance (''happy'' face) consists in a shortened nose, full cheeks, hypertelorism, long flat philtrum, and a thin upper lip [orpha.net]

Brachycephaly, prominent eyes, ocular hypertelorism, small nose, thickened upper lip with long and flat philtrum and pectus excavatum were observed ( Figure 1 ). [scielo.br]

Lower Gingival Carcinoma

Persistent tenderness, pain, or numbness anywhere in the mouth or on the lips. A lump or thickening in the cheek or neck. [consumer.healthday.com]

An area in your mouth or pharynx or on your lip that is sore, irritated, lumpy, or thickened. Numbness, tenderness, or pain in your mouth or neck. [sharecare.com]

Mucopolysaccharidosis Type 1

The oral findings included thickened lips, prominent rugae, macroglossia, mouth breathing, tongue thrusting, and anterior open bite. [jisppd.com]

Symptoms can include: Developmental delays and regression Hepatosplenomegaly (enlarged liver and spleen) Coarse facial features with thickened lips, cheeks, tongue, and nose [newbornscreening.info]

Upper Gingival Carcinoma

Other symptoms These can include one or more of the following: a lump or thickening of your lip a lump in your mouth or throat unusual bleeding or numbness in your mouth loose [cancerresearchuk.org]

Persistent tenderness, pain, or numbness anywhere in the mouth or on the lips. A lump or thickening in the cheek or neck. [consumer.healthday.com]

An area in your mouth or pharynx or on your lip that is sore, irritated, lumpy, or thickened. Numbness, tenderness, or pain in your mouth or neck. [sharecare.com]

Autosomal-Recessive Robinow Syndrome

[…] megacephaly - Micrognathia / retrognathia / micrognathism / retrognathism - Pectus excavatum - Proptosis / exophthalmos - Rib number anomalies - Scoliosis - Tented upper lip [csbg.cnb.csic.es]

Thickened / hypertrophic / fibromatous gingivae - Umbilical hernia - Undescended / ectopic testes / cryptorchidia / unfixed testes - Upslanted palpebral fissures / mongoloid [csbg.cnb.csic.es]

Geleophysic Dysplasia

Figure 2 - Patients 1 and 2: Ocular hypertelorism, small nose, thickened upper lip with long and flat philtrum, and pectus excavatum. [scielo.br]

Clinical description The characteristic facial appearance (''happy'' face) consists in a shortened nose, full cheeks, hypertelorism, long flat philtrum, and a thin upper lip [orpha.net]

Other distinctive features include progressive cardiac valvular thickening often leading to an early death, toe walking, tracheal stenosis, respiratory insufficiency, and [diseaseinfosearch.org]

Multiple Endocrine Neoplasia Type 4

The thickening of the lips and eyelids are secondary to the mucosal neuromas. [webeye.ophth.uiowa.edu]

MEN2B is suspected in children with mucosal neuromas, meaning lumps on the tip of the tongue, and typical facial features, such as thickened lips. [cancer.net]

[…] with thickened mucosa [Figure 1 ] Figure 1 – Full appearing lips with thickened mucosa Figure 2 – A) Large, erythematous upper eyelid lesion on the lateral canthus of the [webeye.ophth.uiowa.edu]

Donohue Syndrome

Affected infants may show a wide variety of distinctive facial features such as underdeveloped, huge, low-set ears; macrostomia with thickened lips; hypertelorism; microcephaly [symptoma.com]

Patients have an elfin or gnome-like face with microcephaly, protuberant and low-set ears, large, wide-set eyes, high arched palate, thickened lips, and severely diminished [accessanesthesiology.mhmedical.com]

The areola showed a yellowish thickened plaque of 5-cm diameter that corresponded to a hyperplasia of the sebaceous glands. [ncbi.nlm.nih.gov]

Luscan-Lumish Syndrome

Association with mildly everted lower eyelids, flat malar area, thickened lower lip and craniosynostosis has been reported. [ncbi.nlm.nih.gov]

X-Linked Mandibulofacial Dysostosis

Xq26 300037 Simpson dysmorphia syndrome 312870 X disproportionately large head, coarse facies, large protruding jaw, wide nasal bridge, upturned nasal tip, large mouth, thickened [widesmiles2.org]

lips, central cleft of lower lip, midline groove of tongue and inferior alveolar ridge, enlarged tongue, short neck ENZ Phenylalanine hydroxylase PAH 12q24.1 261600 Phenylketonuria [widesmiles2.org]

Winchester Syndrome

The cutaneous manifestations of this syndrome include leathery thickening of the skin, hyperpigmentation and hypertrichosis. The lips and gingiva are hypertrophic. [ncbi.nlm.nih.gov]

Thick skin / pachydermia / orange skin - Thickened / hypertrophic / fibromatous gingivae Occasional - Atrial septal defect / interauricular communication - Subcutaneous [csbg.cnb.csic.es]

[…] bossing / prominent forehead - Hirsutism / hypertrichosis / Increased body hair - Irregular / in bands / reticular skin hyperpigmentation - Long / large / bulbous nose - Thick lips [csbg.cnb.csic.es]