Lip Thickening Causes & Reasons

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Lip Thickening Symptom Checker: Possible causes include Mucopolysaccharidosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Mucopolysaccharidosis

A distinctive facies with thickening of lips and nostrils as well as an enlarged and protruding tongue forms slowly and may become evident between 2-4 years of age, later [orpha.net]

Increased accumulation of mucopolysaccharides leads to characteristic facial features such as thickened lips, enlarged tongue, a full lower aspect of the face, depressed nasal [invitae.com]

Children with the disorder may have coarse facial features, thick nostrils and lips, dwarfism, and hand deformities. [bmt.umn.edu]

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Mucopolysaccharidosis 6

[symptoma.com] Such characteristics include chubby faces, thickened lips due to the overgrowth of the gums ( gingival hypertrophy ), an unusually prominent forehead (frontal [symptoma.com]

Such characteristics include chubby faces, thickened lips due to the overgrowth of the gums (gingival hypertrophy), an unusually prominent forehead (frontal bossing), and [rarediseases.org]

Children with the disorder may have coarse facial features, thick nostrils and lips, dwarfism, and hand deformities. [bmt.umn.edu]

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Vaginal Candidiasis

Chronic, persistent vulvovaginal candidiasis may lead to lichen simplex — thickened, intensely itchy labia majora (the hair -bearing outer lips of the vulva ). [dermnetnz.org]

Chronic, persistent vulvovaginal candidiasis may lead to lichen simplex — thickened, intensely itchy labia majora (the hair-bearing outer lips of the vulva). [dermnetnz.org]

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Stomatitis

[…] saliva: cannot eat dry foods, mild speech impairment (sticky tongue, lips, affecting speech) Oral Dysesthesia The NCI-CTCAE V4.03 definition of grade 2 oral dysesthesia reads [oncologypro.esmo.org]

[…] lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min The MESTT definition of grade 2 dry mouth/hyposalivation reads: Moderate/thickened [oncologypro.esmo.org]

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Actinic Keratosis

Back of hand—scattered, thickened red, scaly patches. Sun-damaged forehead or bald scalp—small red bumps and/or small tan crusts. [nedermatology.com]

Lower lip—fissures filled with dried blood and large keratosis covered with thorny scale. Cheek and ear-crusted lesions—ranging in color from red to brown. [nedermatology.com]

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Atopy

Common elements of AD include pruritus, eczematous lesions, xerosis (dry skin), and lichenification (thickened skin with accentuated skin markings, sometimes called "elephant [hawaii.edu]

Additional common features are periauricular fissures, cheilitis (lip inflammation and cracking, particularly at the mouth corners), and susceptibility to Staphylococcus aureus [hawaii.edu]

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Atrophic Vaginitis

These rejuvinate, thicken and moisten the mucosal folds and lining of the vagina and vaginal lips and improve blood flow to the clitoris. [liverdoctor.com]

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Multiple Endocrine Neoplasia Type 2B

Most affected individuals have characteristic physical features, including full lips, thickened eyelids, high-arched palate, and marfanoid habitus. [diseaseinfosearch.org]

Prominent physical features include full lips, thickened eyelids, high arched palate and a marfanoid habitus. [disorders.eyes.arizona.edu]

lips, nodules on the anterior third of the tongue, abdominal distention, visible peristaltic waves, and roentgenographic evidence of megacolon or diverticulosis of the colon [ncbi.nlm.nih.gov]

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Acanthosis Nigricans

The lips showed filiform papillomas in a symmetrical distribution (Panel A). The tongue was thickened and furrowed. [doi.org]

[…] around the lips and eyes may be the presenting feature The vast majority of cases of malignant AN are secondary to adenocarinoma of the stomach, but other malignancies sometimes [pcds.org.uk]

Other areas of the body are less commonly affected, such as the palms, soles of the feet or lips. [westlakedermatology.com]

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Tarsal Tunnel Syndrome

The right half of lower lip showed cluster of papillomatous lesions [Figure 1]. [ncbi.nlm.nih.gov]

There were keratotic papules on tongue and palatal surface along with thickening and furrowing of tongue [Figure 2]. [ncbi.nlm.nih.gov]

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Endocrine Dysfunction

Symptoms of acromegaly include: Abnormally large lips, nose or tongue Abnormally large or swollen hands or feet Altered facial bone structure Body and joint aches Deep voice [secondopiniongroup.com]

Fatigue and weakness Headaches Overgrowth of bone and cartilage and thickening of the skin Sexual dysfunction, including decreased libido Sleep apnea Vision impairment Common [secondopiniongroup.com]

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Stroke

The patient reported that the skin over the lip thickened gradually over a 3-day period and subsequently became loose, causing discomfort. [cjhr.org]

[…] between the vermilion border of the lip and its adjacent skin • Prominent folds and lip lines • White thickened patches (leukokeratosis) • Discoloured skin with pale or yellow [slideshare.net]

The most common clinical form is the simple cheilitis glandularis, which manifests as a moderate thickening of the lower lip with inflammatory dilated gland duct orifices, [ncbi.nlm.nih.gov]

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Furunculosis

[…] white patch occurring on a mucous membrane, especially inside the mouth, on the lips or on the female genitalia. [edneutrin.duckdns.org]

[…] children under 10, and the average age at the onset of symptoms is Mikoze, psoriaze, furunkuloze, pedikuloze leukoplakia vulvae Lichen sclerosis et atrophicus. leukoplakia A thickened [edneutrin.duckdns.org]

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Left Cardiac Ventricle Disorder

[…] may include: Enlarged heart Heart murmur Rapid breathing Rapid heartbeat Symptoms of DORV may include: Poor feeding from becoming tired easily Bluish color of the skin and lips [medlineplus.gov]

Clubbing (thickening of the nail beds) of toes and fingers (late sign) Failure to gain weight and grow Pale coloring Sweating Swollen legs or abdomen Trouble breathing Treatment [medlineplus.gov]

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Gastric Ulcer

The most common clinical form is the simple cheilitis glandularis, which manifests as a moderate thickening of the lower lip with inflammatory dilated gland duct orifices, [ncbi.nlm.nih.gov]

Actinic cheilitis causes dryness and thickening typically along the line that separates the lips from the skin of the face, otherwise known as the lower vermillion border. [medicalnewstoday.com]

Clinically, the disease manifests with painless thickening and whitish discoloration at the borders of the lips and skin. [ncbi.nlm.nih.gov]

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Paget Disease of the Breast

The skin surface may become thickened with white raised areas. [britishskinfoundation.org.uk]

The rash is usually on the outer lips (labia) of the vulva in women and the penis or scrotum in men, but it can spread backwards to the perineum and anus. [britishskinfoundation.org.uk]

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Ectropion

Her facial and periocular skin was thickened with a cobblestone appearance. Cicatricial ectropions involved both upper and lower eyelids. [ncbi.nlm.nih.gov]

She had previously undergone multiple resections of syringomatous adenomas of both nipples, facial keratoacanthomas, and a lower left lip squamous cell carcinoma. [ncbi.nlm.nih.gov]

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Gigantism - Acromegaly

This leads to a characteristic appearance of the lower jaw and lips, thickening of the fingers and feet, and enlargement of cartilage structures, such as the nose and adams [tallclub.co.uk]

Other symptoms, like increasingly apparent facial features (thickened lips and protruding brows, for example), don’t appear until the diseases have progressed. [medicaldaily.com]

Definition (NCI) A syndrome characterized by enlargement of the hands, feet, ears, nose, lips, and tongue, skin thickening and swelling of internal organs. [fpnotebook.com]

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Gastrointestinal Neoplasm

MEN2B is suspected in children with mucosal neuromas, meaning lumps on the tip of the tongue, and typical facial features, such as thickened lips. [cancer.net]

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Multiple Endocrine Neoplasia

Prominent physical features include full lips, thickened eyelids, high arched palate and a marfanoid habitus. [disorders.eyes.arizona.edu]

The thickening of the lips and eyelids are secondary to the mucosal neuromas. [eyerounds.org]

Neuromas often lead to thickening of the lips and tongue and can also appear as pedunculated nodules on these structures. [disorders.eyes.arizona.edu]

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Skin Neoplasm

[…] and Symptoms of Squamous Cell Carcinoma Squamous cell skin cancers most commonly appear on parts of the body frequently exposed to the sun, such as the face, neck, ears, lips [mskcc.org]

Signs that squamous cells in the skin have begun to grow out of control and have become cancerous include an area that’s become: rough scaly thickened wartlike Other warning [mskcc.org]

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Winchester Syndrome

The cutaneous manifestations of this syndrome include leathery thickening of the skin, hyperpigmentation and hypertrichosis. The lips and gingiva are hypertrophic. [ncbi.nlm.nih.gov]

Thick skin / pachydermia / orange skin - Thickened / hypertrophic / fibromatous gingivae Occasional - Atrial septal defect / interauricular communication - Subcutaneous [csbg.cnb.csic.es]

[…] bossing / prominent forehead - Hirsutism / hypertrichosis / Increased body hair - Irregular / in bands / reticular skin hyperpigmentation - Long / large / bulbous nose - Thick lips [csbg.cnb.csic.es]

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Autosomal Dominant Prognathism

Association with mildly everted lower eyelids, flat malar area, thickened lower lip and craniosynostosis has been reported. [orpha.net]

lips (without a true ’double lip’), overgrowth of the intraoral mucosa resulting in exaggerated rugae and frenula, and thickened upper eyelids leading to narrow palpebral [e-kjgm.org]

Xq26 300037 Simpson dysmorphia syndrome 312870 X disproportionately large head, coarse facies, large protruding jaw, wide nasal bridge, upturned nasal tip, large mouth, thickened [en.wikibooks.org]

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Dehydration

(patulous) everted lips. [orpha.net]

everted lips) and hand anomalies (aplasia or hypoplasia of the middle phalanges of the fifth fingers). [orpha.net]

[…] dysmorphism (wide-set eyes, downslanting palpebral fissures, mild ptosis, flat midface, flat nasal bridge and upturned nasal tip, short philtrum with a triangular mouth, and thickened [orpha.net]

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Malignant Neoplasm of the Skin

Sore that does not heal or an area of thickened skin on the lower lip, especially if you smoke or use chewing tobacco or your lips are often exposed to the sun and wind. [healthlinkbc.ca]

Bowen's disease is another type of scaly or thickened patch on the skin that may turn into squamous cell skin cancer. [theskincancercenter.org]

The growths may appear as rough red or brown patches on the skin, or as cracking or peeling of the lower lip that does not heal. [theskincancercenter.org]

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Milium

Oral cancer refers to cancer that develops anywhere inside your mouth or on your lips. [healthline.com]

Symptoms of oral cancer include: a lump, growth, or thickening of the skin in your mouth a sore that doesn’t heal a bleeding sore jaw pain or stiffness sore throat red or [healthline.com]

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Lymphedema

neck, or area below the chin Discomfort or tightness in any of the affected areas Difficulty moving the neck, jaw, or shoulders Thickening and scarring of the skin on the [cancer.net]

[…] look like an orange peel (swollen with small indentations) Small blisters that leak clear fluid Symptoms of head and neck lymphedema include: Swelling of the eyes, face, lips [cancer.net]

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Squamous Cell Carcinoma of the Skin

[…] skin on the lower lip Wart-like growth or plaque Sore that does not heal Red, scaly patches or bumps The tumors can reach ¾ to 1 inch in size and develop into large masses [web.archive.org]

On the lips an SCC can present as a persistent small ulcer or thickened firm scaly skin. [dermcoll.edu.au]

There is thickening whitish discoloration of the lip at the border of the lip and skin. [mountsinai.org]

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Double Outlet Right Ventricle

[…] may include: Enlarged heart Heart murmur Rapid breathing Rapid heartbeat Symptoms of DORV may include: Poor feeding from becoming tired easily Bluish color of the skin and lips [nlm.nih.gov]

Babies who have DORV may show these symptoms: Tiring easily, especially when feeding Bluish color of the skin and lips Clubbing (thickening of the nail beds) of the fingers [fetaltonewborn.org]

Clubbing (thickening of the nail beds) of toes and fingers (late sign) Failure to gain weight and grow Pale coloring Sweating Swollen legs or abdomen Trouble breathing Treatment [nlm.nih.gov]

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Extramammary Paget Disease

The skin surface may become thickened with white raised areas. [britishskinfoundation.org.uk]

The rash is usually on the outer lips (labia) of the vulva in women and the penis or scrotum in men, but it can spread backwards to the perineum and anus. [britishskinfoundation.org.uk]

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