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Mucopolysaccharidosis 6
Such characteristics include chubby faces, thickened lips due to the overgrowth of the gums (gingival hypertrophy), an unusually prominent forehead (frontal bossing), and[rarediseases.org]
Children with the disorder may have coarse facial features, thick nostrils and lips, dwarfism, and hand deformities.[bmt.umn.edu]
Patients often have vision problems (due to clouded corneas), and severe heart problems (as the coronary artery narrows and the heart valves thicken).[bmt.umn.edu]
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Mucopolysaccharidosis
A distinctive facies with thickening of lips and nostrils as well as an enlarged and protruding tongue forms slowly and may become evident between 2-4 years of age, later[orpha.net]
Increased accumulation of mucopolysaccharides leads to characteristic facial features such as thickened lips, enlarged tongue, a full lower aspect of the face, depressed nasal[invitae.com]
[…] of the lips, tongue, and nostrils.[rarediseases.org]
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Autosomal-Recessive Robinow Syndrome
[…] megacephaly - Micrognathia / retrognathia / micrognathism / retrognathism - Pectus excavatum - Proptosis / exophthalmos - Rib number anomalies - Scoliosis - Tented upper lip[csbg.cnb.csic.es]
- Thickened / hypertrophic / fibromatous gingivae - Umbilical hernia - Undescended / ectopic testes / cryptorchidia / unfixed testes - Upslanted palpebral fissures / mongoloid[csbg.cnb.csic.es]
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Dilated Cardiomyopathy Type 2B
Most affected individuals have characteristic physical features, including full lips, thickened eyelids, high-arched palate, and marfanoid habitus.[diseaseinfosearch.org]
[…] type IIB (MEN2B) is an autosomal dominant hamartoneoplastic syndrome characterized by aggressive medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal neuromas, and thickened[diseaseinfosearch.org]
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Endocrine Dysfunction
Symptoms of acromegaly include: Abnormally large lips, nose or tongue Abnormally large or swollen hands or feet Altered facial bone structure Body and joint aches Deep voice[secondopiniongroup.com]
Fatigue and weakness Headaches Overgrowth of bone and cartilage and thickening of the skin Sexual dysfunction, including decreased libido Sleep apnea Vision impairment Common[secondopiniongroup.com]
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Macrocephaly
, joint laxity, thickened subcutaneous tissue and 2/3 syndactyly of the toes.[ncbi.nlm.nih.gov]
[…] of somatic growth with body asymmetry including brain asymmetry, developmental delay, typical face with full cheeks, nevus flammeus of the nose and/or philtrum and upper lip[ncbi.nlm.nih.gov]
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Acromegaly
[…] accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue thickened ribs (creating a barrel chest) joint pain degenerative arthritis enlarged[hopkinsmedicine.org]
Acromegaly may also cause you to experience gradual changes in the shape of your face, such as a protruding lower jaw and brow, an enlarged nose, thickened lips, and wider[mayoclinic.org]
Symptoms may include: swelling of the hands and feet facial features become coarse as bones grow body hair becomes coarse as the skin thickens and/or darkens increased perspiration[hopkinsmedicine.org]
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Lichen Sclerosus
LS can also cause the genital lips (labia) to thicken and the opening of the vagina to narrow. In an advanced stage of the condition, intercourse is painful.[hospitals.jefferson.edu]
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Lamellar Ichthyosis
These infantile skin symptoms usually include brown scales over the entire body, inversion of the eyelids and lips, thickening of skin on the palms and soles of the feet,[sema4genomics.com]
Lamellar ichthyosis is a rare skin condition that presents as patches of scaly skin and outward turning eyelids and lips.[patientslikeme.com]
lips, marfanoid habitus, megacolon Hay Wells syndrome and other ectodermal dysplasias which cause ankeloblepharon Mild erythroderma in infancy with large translucent scales[brainscape.com]
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Vitamin A Deficiency
Dry, scaly , thickened skin with prominent follicular scale Dry lips and thickened tongue Keratinisation of the urinary, gastrointestinal and respiratory tracts Other symptoms[dermnetnz.org]