Lipid Accumulation: Causes & Reasons

Possible Causes for Lipid Accumulation

The primary biological defect in Niemann-Pick type C disease (NP-C) is impaired intracellular lipid transportation that leads to toxic accumulation of lysosomal lipids. 1 [niemann-pick-c.com]

Niemann-Pick Disease (NP) refers to a group of rare inherited lipid storage diseases in which harmful quantities of fatty substances (lipids) accumulate in the spleen, liver [crnd.nd.edu]

Consequently, excessive amounts of cholesterol accumulate within the liver and spleen and excessive amounts of other lipids accumulate in the brain. [gaois.ie]

Lipid Pneumonia

Lipid pneumonia occurs when one aspirates an oily substance or there is an accumulation of lipid substances in the alveoli. [patientslikeme.com]

Macroscopically, there is parenchymal consolidation that has a characteristic yellowish discoloration due to the accumulation of lipid in the alveoli [ 18 ]. [dx.doi.org]

What is lipid pneumonia? Pneumonia is inflammation of the lungs associated with congestion and fluid accumulation. [patientslikeme.com]

Niemann-Pick Disease

Liver biopsy at 12 months showed lipid accumulation and fibrosis. [ncbi.nlm.nih.gov]

By using this disease model, we also evaluated three compounds that reportedly reduced lysosomal lipid accumulation in Niemann-Pick disease type C as well as enzyme replacement [ncbi.nlm.nih.gov]

Intracellular lipid accumulation has been seen in retinal neurons, amacrine cells, retinal pigment epithelial cells, and receptors. The cornea has stromal haziness. [disorders.eyes.arizona.edu]

Farber Disease

We performed structural and quantitative analyses of three lipids named lipids X, Y and Z. Lipid X accumulated in the liver but not in the brain. [ncbi.nlm.nih.gov]

In affected individuals, lipids accumulate abnormally in cells and tissues throughout the body, particularly around the joints. Three classic signs occur ... 1 ... [familydiagnosis.com]

In affected individuals, harmful amounts of lipids accumulate in cells and tissues throughout the body, particularly around the joints. [ldnz.org.nz]

Cholesterol Ester Storage Disease

A predominantly microvesicular steatosis in CESD patients could not be reliably distinguished from other causes of fatty liver with cytosolic lipid accumulation in fixed paraffin-embedded [ncbi.nlm.nih.gov]

In affected individuals, harmful amounts of fats (lipids) accumulate in cells and tissues throughout the body, which typically causes liver disease. [ghr.nlm.nih.gov]

We confirmed accumulation of glycogen and lipids, particularly cholesterol esters, in the liver of a patient with cholesterol ester storage disease (CESD). [ncbi.nlm.nih.gov]

Niemann-Pick Disease Type B

Intracellular lipid accumulation has been seen in retinal neurons, amacrine cells, retinal pigment epithelial cells, and receptors. The cornea has stromal haziness. [disorders.eyes.arizona.edu]

In Niemann-Pick disease, harmful quantities of lipids accumulate in the brain, spleen, liver, lungs, and bone marrow. [my.clevelandclinic.org]

Niemann-pick disease is a group of autosomal recessive disorder of lipid storage with progressive accumulation of sphingomyelin and other lipids in the lysosomes of various [ncbi.nlm.nih.gov]

Wolman Disease

In affected individuals, harmful amounts of fats (lipids) accumulate in cells and tissues throughout the body, which typically causes liver disease. [ghr.nlm.nih.gov]

The WD NSCs exhibited the hallmark disease phenotypes of neutral lipid accumulation, severely deficient LAL activity, and increased LysoTracker dye staining. [ncbi.nlm.nih.gov]

Although both diseases manifest a type II hyperlipoproteinemic phenotype and hepatomegaly secondary to lipid accumulation, a more malignant clinical course with more significant [ncbi.nlm.nih.gov]

Xanthoma Disseminatum

The disease is believed to be a granulomatous histiocytic proliferation in which lipid accumulation is secondary and is unassociated with systemic disturbances of lipid metabolism [jamanetwork.com]

They are cutaneous manifestations of lipidosis in which lipids accumulate in large foam cells within the skin. [en.wikipedia.org]

Inflammation and lipid accumulation in xanthoma disseminatum: therapeutic considerations. J Am Acad Dermatol 2008;58:S47–S49. 19. [anndermatol.org]

Sea-blue histiocytosis

It is due to accumulation of sphingomyelin. - Spleen, Liver, Lymphnodes and Bone marrow: Massive accumulation of lipid-laden cells of the mononuclear phagocytic system, giving [pathopedia-india.com]

Sphingomyelin is a component of cell membrane including the organellar membrane, so the enzyme deficiency blocks degradation of lipid, resulting in the accumulation of sphingomyelin [medicowesome.com]

The main defects occur due to accumulation of unesterified cholesterol and glycolipids within the lysosomal system. [1], [2] The pattern in which the lipids accumulate within [neurologyindia.com]

Disorder of Lipid Metabolism

Under energy-rich conditions, lipids synthesis is highly conservative; under energy-poor conditions, lipids accumulation enables organisms to survive, and stored lipids are [link.springer.com]

Over time, accumulations of these substances can be harmful to many organs of the body. Lipidoses are disorders caused by the accumulation of lipids. [merckmanuals.com]

Lipid metabolism disorder is caused by abnormality in metabolism of lipids leading to accumulation of harmful substances in the body. [xpertdox.com]

Myopathic Carnitine Deficiency

Lipid accumulation in muscle was observed in 2 of 8 patients. [ncbi.nlm.nih.gov]

Electron microscopy often confirms the abnormal lipid accumulation with minimal or no increase of mitochondria [checkorphan.org]

[…] characterized by prominent lipid accumulation in muscle fibers due to lipid dysmetabolism. [allmedx.com]

Tangier Disease

Lipid accumulation chiefly affected the Schwann cells of unmyelinated fibers and, to a lesser degree, of myelinated fibers, endoneurial fibroblast, and vasa nervorum. [ncbi.nlm.nih.gov]

Tangier disease: A case with sensorimotor distal polyneuropathy and lipid accumulation in striated muscle and vasa nervorum. [annalsofian.org]

The L5 dorsal root and the superficial peroneal nerve showed fiber loss and lipid vacuole accumulation in Schwann cell cytoplasm. [ncbi.nlm.nih.gov]

Cerebral Lipidosis

accumulation of lipids in the brain and the central nervous system. [symptoma.com]

Report of a case with unusual mitochondrial changes and lipid accumulation in muscle. 62 Mastaglia FL...Beveridge B 591993 1977 6 [Adult type of cerebral lipidosis with multilamellar [malacards.org]

A lipid storage disorder (or lipidosis ) is any one of a group of inherited metabolic disorders in which harmful amounts of fats or lipids accumulate in some of the body’s [en.wikipedia.org]

Alcoholic Fatty Liver

While lipid export initially increases, it plateaus and may even decrease with disease progression, sustaining the accumulation of lipids. [ncbi.nlm.nih.gov]

Moreover, HFD-treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding protein [ncbi.nlm.nih.gov]

MiR-192-5p overexpression reduced lipid accumulation significantly in PA-treated Huh7 cells, and SCD-1 siRNA transfection abrogated the lipid deposition aggravated by miR- [ncbi.nlm.nih.gov]

Mucolipidosis Type 4

Lipid internalization at 19 degreesC was similar in both cell types; however, 40-60 min after raising the temperature to 37 degreesC, the fluorescent lipid accumulated in [ncbi.nlm.nih.gov]

+ - osis, condition] mucolipidosis a group of inherited lysosomal storage diseases in which mucopolysaccharides and lipids accumulate in tissues. [medical-dictionary.thefreedictionary.com]

Lipid internalization at 19°C was similar in both cell types; however, 40–60 min after raising the temperature to 37°C, the fluorescent lipid accumulated in the lysosomes [doi.org]

Mucolipidosis

+ - osis, condition] mucolipidosis a group of inherited lysosomal storage diseases in which mucopolysaccharides and lipids accumulate in tissues. [medical-dictionary.thefreedictionary.com]

[…] mucolipidosis [ mu″ko-lip″ĭ-do´sis ] (pl. mucolipido´ses ) any of a group of genetic disorders in which both glycosaminoglycans (GAGs) and lipids accumulate in tissues, but [medical-dictionary.thefreedictionary.com]

[…] glycosaminoglycans (mucopolysaccharides) and lipids accumulate in tissues but without excess of the former in the urine. mucolipidosis (myo͞o′kō-lĭp′ĭ-dō′sĭs) n. [medical-dictionary.thefreedictionary.com]

Sjögren-Larsson Syndrome

Because of mutations, abnormal lipid accumulation in the membranes of brain and skin is postulated. [openaccessjournals.com]

[…] of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardati ... [rcsb.org]

The potential disease mechanisms leading to symptoms include: accumulation of toxic fatty aldehydes that form covalent adducts with lipids and membrane proteins; physical [nijp.org]

Gaucher Disease Type 2

The correct identification of the sugar in the sphingolipid compound was not achieved until 1934, when Aghion demonstrated that the lipid accumulating in the tissues of patients [medlink.com]

When you don’t make enough glucocerebrosidase, your body doesn’t break down lipids properly. As a result, the lipids accumulate around your organs. [healthline.com]

These mutations result in defects in the synthesis of an enzyme called glucocerebrosidase, leading to the accumulation of lipids called glucocerebrosides in Gaucher cells. [britannica.com]

Fatty Liver

The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. [mesh.kib.ki.se]

The expression of hepatic genes involved in lipid droplet accumulation and in fatty acid uptake also decreased upon treatment of HFD-fed mice with the extracts. [ncbi.nlm.nih.gov]

In HepG2 cells, taurine suppressed the fatty acid-induced lipid accumulation, production of reactive oxygen species and TBARS level, and amelioration of the fatty acid-induced [ncbi.nlm.nih.gov]

Pseudo-Hurler Polydystrophy

In ML, abnormal amounts of carbohydrates and fatty materials (lipids) accumulate in cells. [ninds.nih.gov]

[…] storage disease due to deficiency of acid lipase; results in accumulation of neutral lipids, particularly cholesterol esters, within cells X-linked lysosomal storage disease [icd9data.com]

[…] of carbohydrates, lipids, and proteins in the inclusion bodies. [ citation needed ] Diagnosis This section is empty. [wikiwand.com]

Glycogen Storage Disease Type 10

accumulate in the spleen, liver, lungs, bone marrow, and brain. [checkrare.com]

[…] raised liver glycogen Histology: PAS pos cyoplasmic abnormal glycogen, some lipid accumulation RBC Glycogen: Normal Tissue Glycogen: Muscle glycogen conc may be normal Histology [quizlet.com]

Lipids accumulate in the muscle, forming small lipid droplets. Treatment Carnitine supplementation has produced variable treatment results. [what-when-how.com]

Abetalipoproteinemia

The defective secretion of chylomicrons and VLDL causes lipid accumulation in the cytoplasm of intestinal epithelial cells and hepatocytes. [medigoo.com]

Electron microscopy is essential to demonstrate lipid accumulation in enterocytes in such patients. [journals.lww.com]

Additionally, lipids may accumulate in liver cells (hepatic steatosis). [online.epocrates.com]

Gaucher Disease

It is characterized by lipid accumulation in certain cells and organs, particularly macrophages, which appear on light microscopy as 'Gaucher cells' or vacuolated lipid-laden [ncbi.nlm.nih.gov]

The lipid accumulates in cells (called reticuloendothelial cells) in the liver and spleen and other cell types throughout the body including the nerve ganglion cells of the [medicinenet.com]

The correct identification of the sugar in the sphingolipid compound was not achieved until 1934, when Aghion demonstrated that the lipid accumulating in the tissues of patients [medlink.com]

Tubular Adenocarcinoma

and degeneration due to lipid accumulation [6, 9]. [diagnosticpathology.biomedcentral.com]

We were unable to verify the well-known causes of clear cytoplasm, such as an accumulation of glycogen, lipid, or mucin and enteroblastic differentiation. [diagnosticpathology.biomedcentral.com]

Generally, an accumulation of glycogen, mucin, and lipid, as well as enteroblastic differentiation, are well-known examples of the etiology or substances of clear cells in [diagnosticpathology.biomedcentral.com]

Chitotriosidase Deficiency

particularly cholesterol and cholesterol ester, into the cells through a scavenger receptor–mediated process.6 This lipid accumulation promotes the expression of different [ahajournals.org]

In accordance with this, it has been reported that chitotriosidase activity is related to intracellular lipid accumulation in Gaucher’s disease12,33,34 and does not modify [ahajournals.org]

[…] of lipid-laden macrophages during the gradual progression of atherosclerosis in relation to age. [ahajournals.org]

Cephalin Lipidosis

No abnormally accumulated lipid was present, however, within the myenteric ganglion cells available for examination. [amjmed.com]

Arch Dis Child 29:48–54 CrossRef PubMed CAS Google Scholar Byrd III JC, Powers JM (1979) Wolman’s disease: ultrastructural evidence of lipid accumulation in central and peripheral [link.springer.com]

[…] storage disease due to deficiency of acid lipase; results in accumulation of neutral lipids, particularly cholesterol esters, within cells X-linked lysosomal storage disease [icd9data.com]

Congenital Visceral Steatosis

The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. [decs.bvsalud.org]

accumulation in fatty liver. [decs.bvsalud.org]

Hepatic [C06.552.933] Tuberculosis, Hepatic Zellweger Syndrome [C06.552.970] Zellweger Syndrome Fatty Liver - Concepto preferido UI del concepto M0008275 Nota de alcance Lipid [decs.bvsalud.org]

Primary Coenzyme Q10 Deficiency Type 1

Anheim M, Fleury M, Monga B, Laugel V, Chaigne D, Rodier G, Ginglinger E, Boulay C, Courtois S, Drouot N, Fritsch M, Delaunoy JP, Stoppa-Lyonnet D, Tranchant C, Koenig M. Epidemiological, clinical, paraclinical and molecular study of a cohort of 102 patients affected with autosomal recessive progressive cerebellar ataxia[…] [ncbi.nlm.nih.gov]

Lysosomal Acid Lipase Deficiency

In affected individuals, harmful amounts of fats (lipids) accumulate in cells and tissues throughout the body, which typically causes liver disease. [medlineplus.gov]

[…] drugs.1,2 However, the use of lipid-lowering drugs is not always effective and does not correct the enzymatic defect or prevent lipid accumulation.1,3 In 2015, the use of [analesdepediatria.org]

Consistent with previously published findings,5,6,7 fibrosis and lipid accumulation in the liver were common in this study. [nature.com]

Adult Progressive Spinal Muscular Atrophy Aran Duchenne Type

[…] features that define a number of primary myopathies such as vacuolation and excess glycogen in the glycogenoses (Cardiff, 1966; Bartram et al., 1995; Wolfe et al., 2000), lipid [taylorfrancis.com]

accumulation in fatty acid oxidation defects (Angelini et al., 1981; Turnbull et al., 1987; Walton et al., 1994); αactinin containing rods in the nemaline myopathies (Yamaguchi [taylorfrancis.com]