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1,434 Possible Causes for Lipid Accumulation

  • Insulin Resistance

    Lipid accumulation, oxidative stress, glucose uptake and cell inflammation were evaluated by cellular biochemical assay, respectively.[ncbi.nlm.nih.gov] Histological examinations indicated that administration of BSSEE obviously reduced hepatic lipid accumulation.[ncbi.nlm.nih.gov] accumulation product, homeostatic model, insulin sensitivity index, and modified glycemic curve following oral glucose load).[ncbi.nlm.nih.gov]

  • Niemann-Pick Disease

    Liver biopsy at 12 months showed lipid accumulation and fibrosis.[ncbi.nlm.nih.gov] By using this disease model, we also evaluated three compounds that reportedly reduced lysosomal lipid accumulation in Niemann-Pick disease type C as well as enzyme replacement[ncbi.nlm.nih.gov] Intracellular lipid accumulation has been seen in retinal neurons, amacrine cells, retinal pigment epithelial cells, and receptors. The cornea has stromal haziness.[disorders.eyes.arizona.edu]

  • Wolman Disease

    Harmful amounts of lipids accumulate in the spleen, liver, bone marrow, intestine, adrenal glands, and lymph nodes.[ncbi.nlm.nih.gov] The WD NSCs exhibited the hallmark disease phenotypes of neutral lipid accumulation, severely deficient LAL activity, and increased LysoTracker dye staining.[ncbi.nlm.nih.gov] In affected individuals, harmful amounts of fats (lipids) accumulate in cells and tissues throughout the body, which typically causes liver disease.[ghr.nlm.nih.gov]

  • Vitamin D Deficiency

    Yang Yang, Jingjing Wang, Yongmin Zhang, Jing Li and Wenji Sun, Black Sesame Seeds Ethanol Extract Ameliorates Hepatic Lipid Accumulation, Oxidative Stress, and Insulin Resistance[doi.org]

  • Metabolic Syndrome

    accumulation and inflammatory cell infiltration without improving liver damage.[ncbi.nlm.nih.gov] […] overaccumulation, the lipid accumulation product (LAP), has been proposed.[ncbi.nlm.nih.gov] A few important definitions are reviewed in this paper and, at the end, a simplified clinical definition is given and a simple parameter - lipid accumulation product - is[dx.doi.org]

  • Farber Disease

    In affected individuals, lipids accumulate abnormally in cells and tissues throughout the body, particularly around the joints. Three classic signs occur ... 1 ...[familydiagnosis.com] In affected individuals, harmful amounts of lipids accumulate in cells and tissues throughout the body, particularly around the joints.[ldnz.org.nz] In affected individuals, lipids accumulate abnormally in cells and tissues throughout the body, particularly around the joints.[ghr.nlm.nih.gov]

  • Niemann-Pick Disease Type B

    Intracellular lipid accumulation has been seen in retinal neurons, amacrine cells, retinal pigment epithelial cells, and receptors. The cornea has stromal haziness.[disorders.eyes.arizona.edu] Niemann-pick disease is a group of autosomal recessive disorder of lipid storage with progressive accumulation of sphingomyelin and other lipids in the lysosomes of various[ncbi.nlm.nih.gov] In Niemann-Pick disease, harmful quantities of lipids accumulate in the brain, spleen, liver, lungs, and bone marrow.[my.clevelandclinic.org]

  • Cholesterol Ester Storage Disease

    A predominantly microvesicular steatosis in CESD patients could not be reliably distinguished from other causes of fatty liver with cytosolic lipid accumulation in fixed paraffin-embedded[ncbi.nlm.nih.gov] We confirmed accumulation of glycogen and lipids, particularly cholesterol esters, in the liver of a patient with cholesterol ester storage disease (CESD).[ncbi.nlm.nih.gov] With regards to cholesterol esters stored elsewhere, lipid accumulation within lysosomes of hepatocytes may strongly interfere with liver function and eventually provoke liver[symptoma.com]

  • Niemann-Pick Disease Type C

    NPC1 and NPC2 encode for proteins that bind and transport cholesterol and other lipids, and if these proteins are dysfunctional, lipids accumulate within cell organelles known[symptoma.com] The primary biological defect in Niemann-Pick type C disease (NP-C) is impaired intracellular lipid transportation that leads to toxic accumulation of lysosomal lipids. 1[niemann-pick-c.com] Niemann-Pick Disease (NP) refers to a group of rare inherited lipid storage diseases in which harmful quantities of fatty substances (lipids) accumulate in the spleen, liver[crnd.nd.edu]

  • Hypertension

    Pathologically, the process begins with the accumulation of abnormal lipids in the vascular intima, a reversible stage, progresses to an advanced stage in which a core of[doi.org]

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