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64 Possible Causes for Lipid and Glycogen Accumulation

  • Insulin Resistance

    Vitamin C deficiency also worsened liver lipid accumulation and inflammation in TNF-α-treated Gulo -/- mice.[] Intrahepatic lipid accumulation is increased and triglycerides are secreted in the form of very-low-density lipoproteins.[] In HepG2 cells, vitamin C reversed the TNF-α-induced reduction of glucose uptake and glycogen synthesis, which were mediated by increasing GLUT2 levels and the activation[]

  • Renal Cell Carcinoma

    Because these cells accumulate glycogen and lipids, their cytoplasm appears "clear", lipid-laden, the nuclei remain in the middle of the cells, and the cellular membrane is[] Because these cells accumulate glycogen and lipids, their cytoplasm appear " clear ", lipid-laden, the nuclei remain in the middle of the cells, and the cellular membrane[]

  • Chromophobe Renal Cell Carcinoma

    The transparency of the cytoplasm results from accumulated droplets of glycogen, phospholipids, and neutral lipids-in particular, cholesterol ester. [42, 43] Glycogen can[] Other organelles such as Golgi bodies and rough endoplasmic reticulum tend to be absent or sparse and may be pushed to the cell periphery by accumulations of lipid and glycogen[] Distinctive features include long microvilli typical of the brush border seen in renal proximal tubules and abundant lipid vacuoles and glycogen deposits.[]

  • Renal Carcinoma

    The cytoplasm is clear, due to an intensive intracytoplasmatic accumulation of glycogen and lipids. Usually, the nuclei are condensed and hyperchromatic.[]

  • Histiocytoid Cardiomyopathy

    The accumulation of glycogen and fat, both of which normally serve as sources of energy for contraction, may reflect the loss of contractile function in these cells, and lipid[]

  • Alcoholic Myopathy

    Ultrastructural alterations as lipid and glycogen accumulation or mitochondrial and myofibrillar alterations were nonspecific and observed in nearly all the cases where atrophy[]

  • Diabetic Coma

    Vacuolization of the renal tubular epithelial cells (the Armanni-Ebstein lesion) associated with diabetic hyperglycemia is usually regarded as an accumulation of glycogen.[] In a case of death of diabetic coma, the vacuoles were stained strongly for lipids.[]

  • Mauriac's Syndrome

    It manifests as hepatomegaly, growth delay, elevated liver enzymes, and serum lipids and glycogen accumulation in hepatocytes.[] This contrasts to NASH, where lipid accumulation in the liver develops as a result of chronic hyperinsulinemia and hepatocellular insulin resistance. [7] [12] [13] Conclusion[] Glycogen is then trapped within the hepatocytes as a result of a vicious cycle of hyperglycemia and insulin treatment.[]

  • Toxic Hepatitis

    Moderate sinusoidal compression, interhepatocytic free glycogen particles, and mild increase in lipid droplets were also found.[] It is concluded that the hepatomegaly noted in patients given short-term, high-dosage steroid therapy is due to excessive glycogen accumulation within parenchymal cells.[]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2T

    A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids.[]

Further symptoms