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9 Possible Causes for Lipid Vacuoles in Corneocytes

  • Congenital Ichthyosis

    Dökmeci-Emre S, Taşkıran ZE, Yüzbaşıoğlu A, Önal G, Akarsu AN, Karaduman A, Özgüç M. Identification of two novel PNPLA1 mutations in Turkish families with autosomal recessive congenital ichthyosis. Turk J Pediatr 2017; 59: 475-482. Autosomal recessive congenital ichthyosis (ARCI) is a group of inherited keratinization[…][ncbi.nlm.nih.gov]

  • Palmoplantar Keratosis

    Electron microscopic features include lipid-like vacuoles in corneocytes and granulocytes, a reduction in tonofilaments, and irregular keratohyalin granules.[intechopen.com]

  • Harlequin Type Ichthyosis

    Abnormal lipid-containing vacuoles form in the cytoplasm of the corneocytes. The stratum corneum is remarkably thickened and does not desquame.[jci.org] As a result, exocytosis of lamellar granule content is reduced and intercellular lipid lamellae are absent.[jci.org]

  • Autosomal Recessive Congenital Ichthyosis Type 4

    Abnormal lipid-containing vacuoles form in the cytoplasm of the corneocytes. The stratum corneum is remarkably thickened and does not desquame.[jci.org] As a result, exocytosis of lamellar granule content is reduced and intercellular lipid lamellae are absent.[jci.org]

  • Etretinate

    […] membrane coating granules (MCG) and lipid like vacuoles.[ncbi.nlm.nih.gov] Ultrastructural examination disclosed that the spinous cells and granular cells contained marked swollen mitochondria, many desmosomes, and that corneocytes contained many[ncbi.nlm.nih.gov]

  • Erythrokeratoderma

    […] lymphocytic infiltrate in upper dermis) or electron microscopic features (granular cells containing swollen mitochondria, corneocytes with lipid-like vacuoles) being not[e-ijd.org] This is true particularly in view of histopathologic features (hyperkeratosis, acanthosis, papillomatosis, variable perinuclear vacuolation of keratinocytes, sparse perivascular[e-ijd.org]

  • Thost-Unna Palmoplantar Keratoderma

    Electron microscopic features include lipid-like vacuoles in corneocytes and granulocytes, a reduction in tonofilaments, and irregular keratohyalin granules.[intechopen.com]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    vacuoles in corneocytes, abnormally shaped keratohyaline granules and a reduction in tonofilaments. 656 Vacuoles and many membrane-coating granules were seen in corneocytes[plasticsurgerykey.com] […] not occur in the stratum corneum. 422 Nucleolar hypertrophy has been noted in the punctate form. 582 Ultrastructural studies of the Papillon–Lefèvre syndrome have shown lipid-like[plasticsurgerykey.com]

  • Neu-Laxova Syndrome Type 2

    vacuoles in corneocytes, abnormally shaped keratohyaline granules and a reduction in tonofilaments. 656 Vacuoles and many membrane-coating granules were seen in corneocytes[plasticsurgerykey.com] […] not occur in the stratum corneum. 422 Nucleolar hypertrophy has been noted in the punctate form. 582 Ultrastructural studies of the Papillon–Lefèvre syndrome have shown lipid-like[plasticsurgerykey.com]

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