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112 Possible Causes for Lipoprotein Lipase Decreased

  • Metabolic Syndrome

    A decrease in the clearance of triglycerides in fructose-fed rats has been attributed to a reduction in lipoprotein lipase activity in endothelial cells ( 19, 30 ); whether[doi.org] Therefore the activity of lipoprotein lipase is reduced in AT and the triglyceride clearance is decreased.[dx.doi.org]

  • Insulin Resistance

    TG clearance, increased lipoprotein lipase activity, and increased de novo lipogenesis.[doi.org] Several theories are proposed for the overproduction of VLDL: more TG per VLDL particle, increases in particle number, changes in the production rates of VLDL TG or apoB, decreased[doi.org]

  • Hyperuricemia

    A decrease in the clearance of triglycerides in fructose-fed rats has been attributed to a reduction in lipoprotein lipase activity in endothelial cells ( 19, 30 ); whether[doi.org]

  • Hypercholesterolemia

    Typically, after interacting with hepatic lipase, HDL 2 reverts back to HDL 3 as a function of the decreased lipid remaining in the lipoprotein core ( 2 ).[doi.org] Enzymes imperative for the removal of triglyceride rich lipoproteins are also decreased in HIV patients. This includes lipoprotein lipase and hepatic lipase.[ncbi.nlm.nih.gov] LDL is low-density lipoprotein, VLDL is very low-density lipoprotein, IDL is intermediate-density lipoprotein, HDL is high-density lipoprotein, and LPL is lipoprotein lipase[emedicine.com]

  • Non-Small Cell Lung Carcinoma

    In an Atm-dependent manner, chloroquine decreased macrophage lipoprotein lipase activity, decreased blood pressure, and improved glucose tolerance.[doi.org] Treatment of Atm / ApoE / mice with low-dose, weekly chloroquine decreased atherosclerosis.[doi.org]

  • Coronary Atherosclerosis

    […] determinant of plasma triglyceride metabolism is lipoprotein lipase, and genetic variants that decrease LPL function confer increased cardiovascular risk 54, 56 – 58 and all-cause[doi.org] However, genetic studies have lent credence to the hypothesis that triglyceride-rich lipoproteins or their remnants have a causative role in atherosclerosis. 55 The major[doi.org]

  • Liver Cirrhosis

    A, B, C—Child-Pugh scores Discussion In general, the plasma lipids and lipoproteins tend to decrease with parenchymal liver disease, and the level and composition of the lipoproteins[dx.doi.org] These include lipoprotein lipase (LPL), lecithin-cholesterol acyltransferase (LCAT), and hepatic triglyceride lipase (HTGL) [ 4, 9 ].[dx.doi.org]

  • Familial Hypercholesterolemia

    lipase deficiency Lipoprotein lipase mutation, Apo C-II deficiency Increased triglycerides, decreased HDL (type I) Familial dysbetalipoproteinaemia Apo E2 homozygosity Increased[diapedia.org] Type I a 238600 Buerger-Gruetz syndrome or familial hyperchylomicronemia Decreased lipoprotein lipase (LPL) Chylomicrons Acute pancreatitis, lipemia retinalis, eruptive skin[en.wikipedia.org] […] type IV) or increased total chol, LDL and triglycerides (type IIb) Familial hypertriglyceridaemia Increased VLDL particle number Increased triglycerides (type IV) Familial lipoprotein[diapedia.org]

  • Arteriosclerosis

    The decrease in VLDL and triglyceride levels results from the ability of fibric acid derivatives to enhance the synthesis of lipoprotein lipase.[emedicine.com] These agents increase the activity of lipoprotein lipase and enhance the catabolism of triglyceride-rich lipoproteins, which is responsible for an increase in the HDL cholesterol[emedicine.com] Levels may be expected to decrease by 10-15%.[emedicine.com]

  • Chronic Kidney Disease

    HTG in CKD is caused mainly by the decreased efficiency of lipoprotein lipase (LPL)-mediated very low density lipoprotein triglyceride (VLDL-TG) lipolysis.[ncbi.nlm.nih.gov] The reduced fractional catabolic rate is likely due to the decreased activity of two endothelium-associated lipases, namely, LPL and hepatic triglyceride lipase, which have[jasn.asnjournals.org] BACKGROUND/AIMS: Hypertriglyceridaemia (HTG) and reduction and dysfunction of high density lipoprotein (HDL) are common lipid disturbances in chronic kidney disease (CKD).[ncbi.nlm.nih.gov]

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