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10 Possible Causes for Liver Biopsy Abnormal, Pancytopenia, Polyclonal Hyperglobulinemia

  • Primary Myelofibrosis

    Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[] The clinical manifestations of PMF include splenomegaly, consequent to extramedullary hematopoiesis, pancytopenias, and an array of potentially debilitating constitutional[]

  • Chronic Active Hepatitis

    […] of the liver biopsies.[] Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[] hyperglobulinemia.[]

  • Chronic Active Hepatitis B

    These abnormalities probably play a role in the immunological dysfunctions underlying chronic liver diseases.[] A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[] hyperglobulinemia.[]

  • H Syndrome

    At 17 months old, he was hospitalized for worsening failure to thrive (weight A liver biopsy revealed mild to moderate chronic active hepatitis (primarily lymphocytic without[] IVIC Syndrome with mild thrombocytopenia and leukocytosis; 4) WT Syndrome involving a wide array of hematologic abnormalities including easy bruising, hypoplastic anemia, pancytopenia[] Fig. 2 Patient 1 Liver Biopsy. a : Medium magnification of a hematoxylin-eosin stained core of the liver biopsy shows mildly expanded portal tract by a mild to moderate amount[]

  • Angioimmunoblastic Lymphadenopathy

    In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[] Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[] The findings of a transjugular liver biopsy were compatible with drug-induced hepatitis manifesting as granulomatous inflammation ( Fig. 5 ).[]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[] […] and thrombotic emboli (e.g., infarctions, Budd-Chiari syndrome ) Risk of acute leukemias Think of PNH if a patient presents with hemolytic anemia, venous thrombosis, and pancytopenia[] A liver biopsy reveals glycogen with an abnormal, amylopectin like structure with long outer chains and missing branches.[]

  • Idiopathic Cryoglobulinemia

    Because chronic HCV infection often progresses without any clinical or laboratory abnormality, only a liver biopsy will show the presence of hepatitis in many patients. 26[] . • However, a high rate of hematologic side effects (mainly grade 3 and 4 pancytopenia) was recorded. 1. Saadoun D, et al.[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[]

  • IgG4 Syndrome

    Abnormal hepatic biochemistries and clinical liver disease in patients with primary Sjögren's syndrome. Ann Hepatol . 2007 Jul-Sep. 6(3):150-5. [Medline] . Daniels TE.[] Further investigations Blood test results showed pancytopenia, leucocytes 3,100 10 9 /L, haemoglobin 10.1 g/dL, haematocrit 28.9%, and platelets 117,000 10 9 /L.[] hyperglobulinemia.[]

  • Hereditary Progressive Mucinous Histiocytosis

    If any of the above are abnormal, consider liver-spleen scan and bone marrow biopsy. 142 Histiocytosis X Proliferation of Langerhans’ cells MC-Bone, Skin, Lymph, Lungs, Liver[] The initial clinical presentation commonly includes fever, hepatosplenomegaly, and pancytopenia. Skin eruptions are described in up to 65% of patients.[] hyperglobulinemia, leukocytosis, anemia, elevated SED rate.[]

  • Prekallikrein Deficiency, Congenital, Autosomal Recessive

    , multiple episodes of hepatitis, and a majority have elevated hepatocellular enzyme levels and abnormalities on liver biopsy ; Between 10 and 20% of patients also have hepatosplenomegaly[] Pancytopenia, arthritis, butterfly rash, diffuse proliferative glomerulonephritis, Libman-Sacks endocarditis. ANA, anti-DNA, anti-Sm, anti-histone (drug-induced lupus).[] […] catecholaminergic polymorphic, 1 604772 180902 Autosomal dominant SACS 13q12.12 Spastic ataxia, Charlevoix-Saguenay type 270550 604490 Autosomal recessive SAMD9L 7q21.2 Ataxia-pancytopenia[]

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