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9 Possible Causes for Liver Biopsy: Ductal Proliferation

  • Primary Sclerosing Cholangitis

    Liver biopsy is useful in the diagnosis of PSC. Bile duct proliferation, inflammation and ductal obliteration are consistent with a diagnosis of PSC. How is PSC treated?[hopkinsmedicine.org] […] of inflammation, ductal proliferation, and ductopenia.[ncbi.nlm.nih.gov] If the patient has no symptoms and is in the early stages, as confirmed by liver biopsy, observation would be a reasonable choice.[hopkinsmedicine.org]

  • Salti-Salem Syndrome

    In newborns with ALGS, bile duct paucity is not always present and the liver biopsy may demonstrate ductal proliferation, resulting in the possible misdiagnosis of ALGS as[dovepress.com] biopsy typically shows paucity of the intrahepatic bile ducts.[dovepress.com] Unremitting cholestasis and progressive liver disease necessitating liver transplantation occur in 15% of individuals with ALGS. 8 To date, it has been difficult to predict[dovepress.com]

  • Congenital Liver Cirrhosis

    A liver biopsy is not required to establish a diagnosis of Caroli’s syndrome, but when obtained, it will show intrahepatic bile duct ectasia and proliferation associated with[healio.com] Combined with the use of gadolinium, it may allow visualization of the dot sign, which is very specific for malformations of the ductal plate.[healio.com]

  • Neonatal Hepatitis

    Periportal ductal proliferation, portal ductal proliferation, portal expansion, cholestasis in neoductules, portal cholestasis and portal-portal bridges suggested extrahepatic[scielo.br] In infants with cholestasis, foci of myeloid metaplasia, whenever present in the liver biopsy, suggested intrahepatic cholestasis.[scielo.br] Key words: liver biopsy, neonatal cholestasis, biliary atresia Introduction Neonatal cholestatic jaundice is defined by the persistence of jaundice of variable intensity,[scielo.br]

  • Alagille Syndrome

    In newborns with ALGS, bile duct paucity is not always present and the liver biopsy may demonstrate ductal proliferation, resulting in the possible misdiagnosis of ALGS as[dovepress.com] In the newborn with ALGS, bile duct paucity is not always present and the liver biopsy may demonstrate ductal proliferation, resulting in the possible misdiagnosis of ALGS[ncbi.nlm.nih.gov] biopsy typically shows paucity of the intrahepatic bile ducts.[dovepress.com]

  • Hairy Cell Leukemia

    In the review made by Wysowski et al 4 the post-mortem examination of the liver showed massive hepatocellular necrosis, collapse of lobules, ductal proliferation, and cholestasis[elsevier.es] The findings in the liver biopsy in our patient were not compatible with these alterations.[elsevier.es]

  • Hardikar Syndrome

    Hardikar syndrome is a multiple congenital anomaly syndrome first characterized in 1992 by Hardikar et al. to describe two individuals with cholestasis, cleft lip/palate, retinal pigmentation, intestinal abnormalities, and genitourinary anomalies. Between 1992 and 2002, four individuals with Hardikar syndrome were reported[…][ncbi.nlm.nih.gov]

  • Isoniazid

    Liver biopsy showed moderate to severe lymphocytic and plasmacytic portal and lobular inflammation, prominent ductal proliferation, moderate cholestasis (predominantly hepatocellular[ncbi.nlm.nih.gov]

  • Caroli Disease

    A liver biopsy is not required to establish a diagnosis of Caroli’s syndrome, but when obtained, it will show intrahepatic bile duct ectasia and proliferation associated with[healio.com] Combined with the use of gadolinium, it may allow visualization of the dot sign, which is very specific for malformations of the ductal plate.[healio.com]

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