22 Possible Causes for Liver Biopsy showing Bile Duct Necrosis in USA

  • Ascending Cholangitis
    Liver Biopsy showing Bile Duct Necrosis

    Ascending or acute cholangitis is a potentially life-threatening bacterial infection of the biliary tree that stems from bile duct obstruction and ascension of bacteria from … ducts from the gastrointestinal tract or the portal venous system. … A complete blood count (CBC) will almost always show leukocytosis, whereas inflammatory parameters - C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen … [1]

  • Primary Sclerosing Cholangitis
    Liver Biopsy showing Bile Duct Necrosis Liver Biopsy showing Periportal Necrosis

    Biopsy of liver tissue is used to assess the extent of damage to the liver. … The resulting scarring of the bile ducts obstructs the flow of bile, which further perpetuates bile duct and liver injury. … Primary sclerosing cholangitis (PSC) is a disease of the bile ducts that causes inflammation and obliterative fibrosis of bile ducts inside and/or outside of the liver.[2] [3]

  • Primary Biliary Cirrhosis
    Liver Biopsy showing Abnormal Bile Duct Proliferation

    On microscopic examination of liver biopsy specimens, PBC is characterized by interlobular bile duct destruction. … The enzyme levels would give an indication of liver disease and extent of damage to bile ducts. … It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis … [4] [5]

  • Alcoholic Hepatitis
    Liver Biopsy showing Abnormal Bile Duct Proliferation Liver Biopsy showing Hepatocyte Necrosis

    The changes on liver biopsy are important in confirming a clinical diagnosis. … These include blood tests to determine presence of anemia, liver function tests, CT scan and MRI of the liver and liver biopsy. … When the above mentioned tests fail to draw out a confirmed diagnosis then liver biopsy may be done.[6] [7]

  • Portal Cirrhosis
    Liver Biopsy showing Abnormal Bile Duct Proliferation

    Therefore, it is helpful to break the disease down into three stages: 1) the fatty liver stage, 2) the fibrotic liver stage and 3) the nodular liver stage. … In early stages the liver is large and fatty. … In this stage, the liver shrinks even further.[8]

  • Hepatitis B
    Liver Biopsy showing Periportal Necrosis Liver Biopsy showing Hepatocyte Necrosis

    Histologic testing is done by performing a liver biopsy especially for chronic hepatitis cases in which the findings show ground glass appearance of hepatocytes due to infiltration … Laboratory tests show altered liver function tests and blood counts. … Also, if a person is vaccinated, he will show anti-HBsAg antibodies positive.[9] [10]

  • Yellow Fever
    Liver Biopsy showing Hepatocyte Necrosis

    Liver biopsy can verify inflammation and necrosis of hepatocytes and detect viral antigens. … The historical record shows an outbreak of yellow fever occurred in Recife, Brazil, between 1685 and 1690. … Because of the bleeding tendency of yellow fever patients, a biopsy is only advisable post mortem to confirm the cause of death.[11] [12]

  • Acetaminophen Overdose
    Liver Biopsy showing Hepatocyte Necrosis

    In addition, liver function test is also carried out. … Such sequence of events paves way for development of liver injury. … Liver injury is the most common complication of acetaminophen overdose.[13]

  • Massive Hepatic Necrosis
    Liver Biopsy showing Periportal Necrosis Liver Biopsy showing Hepatocyte Necrosis
  • Drug-induced Toxic Hepatitis
    Liver Biopsy showing Hepatocyte Necrosis

Further symptoms

Similar symptoms

References

  1. Ascending Cholangitis, Symptoma
  2. Primary Sclerosing Cholangitis, Symptoma
  3. Primary sclerosing cholangitis, Wikipedia, CC-BY-SA-3.0
  4. Primary Biliary Cirrhosis, Symptoma
  5. Primary biliary cholangitis, Wikipedia, CC-BY-SA-3.0
  6. Alcoholic Hepatitis, Symptoma
  7. Alcoholic hepatitis, Wikipedia, CC-BY-SA-3.0
  8. Laennec's cirrhosis, Wikipedia, CC-BY-SA-3.0
  9. Hepatitis B, Symptoma
  10. Hepatitis B, Wikipedia, CC-BY-SA-3.0
  11. Yellow Fever, Symptoma
  12. Yellow fever, Wikipedia, CC-BY-SA-3.0
  13. Acetaminophen Overdose, Symptoma