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20 Possible Causes for Liver Biopsy showing Bile Duct Necrosis

  • Ascending Cholangitis

    Abstract An intussusception-type antireflux valve was created in the Roux-en-Y loop in 23 infants with biliary atresia (17 new cases, and six others after episodes of ascending cholangitis) and 10 patients with congenital bile duct dilatation, in order to prevent ascending cholangitis after hepatic portojejunostomy.[…][ncbi.nlm.nih.gov]

  • Primary Sclerosing Cholangitis

    Clin Liver Dis. 2017 Nov;21(4):725-737. doi: 10.1016/j.cld.2017.06.004. Epub 2017 Jul 25. Author information 1 Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55901, USA. Electronic address: Gossard.andrea@mayo.edu. 2 Division of Gastroenterology and Hepatology, Mayo Clinic,[…][ncbi.nlm.nih.gov]

  • Familial Hypercholanemia

    Liver biopsy showed piecemeal necrosis with early cirrhosis and no bile stasis or bile duct proliferation.[pediatriconcall.com] Ultrasound abdomen showed mild hepatosplenomegaly with gall bladder sludge.[pediatriconcall.com] ., partial thromboplastin time 31.7 sec, cholesterol 190 mg, dl and serum bile acids of 152.4 µmol, L {Normal 0 - 10 µmol, L}.[pediatriconcall.com]

  • Bile Duct Stricture

    […] dilated IHBR and showed stricture of CHD at liver hilum; Histopathological examination of biopsy from bile duct revealed epitheliod cell granulomas and caseous necrosis;[oapublishinglondon.com] Iwai et al. 12 A 36-year-old woman presented with painless progressive jaundice; CT of abdomen revealed dilated IHDR andmultiple hypo dense lesions in liver; ERCP confirmed[oapublishinglondon.com]

  • Cholestasis

    Liver biopsy showed significant cholestasis and mild intraparenchymal neutrophilic infiltrate in hepatocytes surrounding the central veins with no significant necrosis, bile[acgcasereports.gi.org] duct injury, or steatosis (Figure 1).[acgcasereports.gi.org]

  • Liver Failure

    Liver biopsies in such cases show features of both PBC (granulomatous inflammation and bile duct lesions) and AIH (piecemeal necrosis and spotty hepatocyte necrosis) ( Figure[nature.com] In general, in low-titer AMA-positive patients, if the liver biopsy shows features typical of AIH, such as prominent piecemeal necrosis, numerous plasma cells in the inflammatory[nature.com] […] infiltrate, and lobular hepatitis, without prominent bile duct destruction, and liver tests favor a hepatitic process over chronic cholestasis, clinicians will often consider[nature.com]

  • Congenital Hepatic Fibrosis

    […] and bile-duct hyperplasia but no evidence of previous liver-cell necrosis.[link.springer.com] The gross aspect of the livers at laparotomy was indistinguishable from that of cirrhosis, and the liver wedge biopsies showed generalized portal and interlobular fibrosis[link.springer.com]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] duct proliferation.[merckmanuals.com] Such cases rarely develop into clinically important liver disease or cirrhosis.[merckmanuals.com]

  • Liver Disease

    Liver biopsies in such cases show features of both PBC (granulomatous inflammation and bile duct lesions) and AIH (piecemeal necrosis and spotty hepatocyte necrosis) ( Figure[nature.com] In general, in low-titer AMA-positive patients, if the liver biopsy shows features typical of AIH, such as prominent piecemeal necrosis, numerous plasma cells in the inflammatory[nature.com] […] infiltrate, and lobular hepatitis, without prominent bile duct destruction, and liver tests favor a hepatitic process over chronic cholestasis, clinicians will often consider[nature.com]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Liver biopsies in such cases show features of both PBC (granulomatous inflammation and bile duct lesions) and AIH (piecemeal necrosis and spotty hepatocyte necrosis) ( Figure[dx.doi.org] duct proliferation.[merckmanuals.com]

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