Ascending or acute cholangitis is a potentially life-threatening bacterial infection of the biliary tree that stems from bileduct obstruction and ascension of bacteria from … ducts from the gastrointestinal tract or the portal venous system. … A complete blood count (CBC) will almost always show leukocytosis, whereas inflammatory parameters - C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen … 
Biopsy of liver tissue is used to assess the extent of damage to the liver. … The resulting scarring of the bileducts obstructs the flow of bile, which further perpetuates bileduct and liver injury. … Primary sclerosing cholangitis (PSC) is a disease of the bileducts that causes inflammation and obliterative fibrosis of bileducts inside and/or outside of the liver.
On microscopic examination of liverbiopsy specimens, PBC is characterized by interlobular bileduct destruction. … The enzyme levels would give an indication of liver disease and extent of damage to bileducts. … It results from a slow, progressive destruction of the small bileducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis … 
The changes on liverbiopsy are important in confirming a clinical diagnosis. … These include blood tests to determine presence of anemia, liver function tests, CT scan and MRI of the liver and liverbiopsy. … When the above mentioned tests fail to draw out a confirmed diagnosis then liverbiopsy may be done.
Therefore, it is helpful to break the disease down into three stages: 1) the fatty liver stage, 2) the fibrotic liver stage and 3) the nodular liver stage. … In early stages the liver is large and fatty. … In this stage, the liver shrinks even further.
Histologic testing is done by performing a liverbiopsy especially for chronic hepatitis cases in which the findings show ground glass appearance of hepatocytes due to infiltration … Laboratory tests show altered liver function tests and blood counts. … Also, if a person is vaccinated, he will show anti-HBsAg antibodies positive.
Liverbiopsy can verify inflammation and necrosis of hepatocytes and detect viral antigens. … The historical record shows an outbreak of yellow fever occurred in Recife, Brazil, between 1685 and 1690. … Because of the bleeding tendency of yellow fever patients, a biopsy is only advisable post mortem to confirm the cause of death.