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9 Possible Causes for Liver Biopsy showing Nonspecific Portal Inflammation

  • Primary Sclerosing Cholangitis

    Clin Liver Dis. 2017 Nov;21(4):725-737. doi: 10.1016/j.cld.2017.06.004. Epub 2017 Jul 25. Author information 1 Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55901, USA. Electronic address: Gossard.andrea@mayo.edu. 2 Division of Gastroenterology and Hepatology, Mayo Clinic,[…][ncbi.nlm.nih.gov]

  • Chronic Hepatitis C

    Pegylated interferon alpha (PEG-IFN-α) is widely used to treat chronic hepatitis C in combination with ribavirin. Many adverse effects of PEG-IFN-α, such as hematologic, psychologic, dermatologic, immunologic, and other abnormalities, have been reported, and some serious adverse events lead to PEG-IFN-α treatment[…][ncbi.nlm.nih.gov]

  • Hepatitis C

    Abstract Hepatitis C virus (HCV) is a blood-borne virus that is transmitted most efficiently by direct percutaneous exposures to blood. Infants are at risk of HCV infection primarily as a result of transmission from their infected mothers. However, there is no evidence of mother-to-infant transmission from[…][doi.org]

  • Klatskin Tumor

    Subsequent liver biopsy found mild nonspecific portal inflammation and no evidence of granulomatous disease; stain for IgG4 was negative.[acgcasereports.gi.org] Biopsy showing extensive granulomatous (large arrows) inflammation in the wall of the bile duct (small arrows). Scale bar, 1 μm.[acgcasereports.gi.org]

  • Hepatic Sarcoidosis

    Subsequent liver biopsy found mild nonspecific portal inflammation and no evidence of granulomatous disease; stain for IgG4 was negative.[acgcasereports.gi.org] Biopsy showing extensive granulomatous (large arrows) inflammation in the wall of the bile duct (small arrows). Scale bar, 1 μm.[acgcasereports.gi.org]

  • Diaphragmatic Eventration

    Liver biopsy performed at 7 months of age showed nonspecific chronic portal inflammation, consistent with CMV infection, but CMV immunostains were negative, and serum transaminases[nature.com]

  • Congenital Cytomegalovirus Infection

    Liver biopsy performed at 7 months of age showed nonspecific chronic portal inflammation, consistent with CMV infection, but CMV immunostains were negative, and serum transaminases[nature.com]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    Liver biopsy showed nonspecific portal inflammation, extensive portal fibrosis, and cirrhosis. There was no response to treatment with ursodeoxycholate (UDCA).[findzebra.com] At the age of 3 years, he showed hepatosplenomegaly, elevated serum liver enzymes, increased gamma-glutamyltransferase (GGT1; 612346) activity (6 times normal), and a high[findzebra.com] Orthotopic liver transplantation was performed at the age of 3.5 years.[findzebra.com]

  • Short Stature - Optic Atrophy - Pelger-Huët Anomaly Syndrome

    As there was no definitive infectious or metabolic cause of hepatitis, percutaneous liver biopsy was undertaken, which showed nonspecific acute hepatocellular injury.[saudijgastro.com] There was mild acute hepatitis with small foci of lobular necrosis and chronic inflammation. No portal fibrosis or bile duct damage was identified.[saudijgastro.com]

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