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19 Possible Causes for Liver Biopsy showing Periportal Necrosis

  • Primary Sclerosing Cholangitis

    Gain of function (GOF) mutation in the p110δ catalytic subunit of the phosphatidylinositol-3-OH kinase (PIK3CD) is the cause of a primary immunodeficiency (PID) characterized by recurrent sinopulmonary infections and lymphoproliferation. We describe a family of two adults and three children with GOF mutation in[…][]

  • Viral Hepatitis

    Viral hepatitis is liver inflammation due to a viral infection. It may present in acute form as a recent infection with relatively rapid onset, or in chronic form. The most common causes of viral hepatitis are the five unrelated hepatotropic viruses hepatitis A, B, C, D, and E. Other viruses can also cause liver[…][]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[] FIGURE 2 Massive hepatic necrosis, and ductular cells from postoperative day (POD) 0 to POD 7 after auxiliary partial orthotopic liver transplantation.[]

  • Isoniazid Hepatitis

    Abstract Two patients with liver failure secondary to isoniazid hepatotoxicity were successfully treated with orthotopic liver transplantation. A 49-year-old man received isoniazid prophylaxis for a positive tuberculin test, and a 60-year-old woman was treated for active pulmonary tuberculosis with isoniazid, rifampin,[…][]

  • Hepatitis B

    Chronic hepatitis B virus (HBV) infection by definition is persistence of hepatitis B surface antigen (HBsAg) in the serum for or 6 months. The risk of developing chronic HBV infection ranges from 90% in neonates to 5% in immunocompetent adults. HBV acquired by perinatal infection has a prolonged immune-tolerant[…][]

  • Hepatitis A

    Surveillance Viral Hepatitis Surveillance – United States, 2011 Viral Hepatitis Surveillance – United States, 2010 Viral Hepatitis Surveillance – United States, 2009 Surveillance Data for Acute Viral Hepatitis – United States, 2008 Surveillance for Acute Viral Hepatitis --- United States, 2007 [PDF - 32 pages] MMWR[…][]

  • Aflatoxicosis

    Abstract A 3-month double-blind and placebo-controlled, phase IIa clinical trial was conducted in Ghana to investigate the safety, tolerance and aflatoxin-sorption efficacy of dietary NovaSil (NS). Volunteers (507 subjects) were clinically screened to evaluate their general health, pregnancy status and blood[…][]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[] Such cases rarely develop into clinically important liver disease or cirrhosis.[]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[]

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