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12 Possible Causes for Liver Biopsy showing Periportal Necrosis, Obstructive Jaundice

  • Primary Sclerosing Cholangitis

    A 46-year-old woman was admitted to our hospital with obstructive jaundice. The liver function tests demonstrated increased serum liver enzyme levels.[] The post-operative course, complicated by cholestatic jaundice, and subsequent clinical complications are described, showing how the diagnosis of sclerosing cholangitis was[] jaundice).[]

  • Viral Hepatitis

    Severe cholestatic jaundice and right upper quadrant abdominal pain may occur in elderly patients.[] Jaundice may occasionally be the initial clinical presentation, in combination with fever and abdominal pain, and can be mistaken for extrahepatic biliary obstruction.[] Severe cholestatic jaundice induced by Epstein-Barr virus infection in the elderly. J Gastroenterol Hepatol 1998; 13: 821-4. [ Links ] 18. Hinedi TB, Koff RS.[]

  • Hepatitis A

    Rarely, a prolonged cholestatic jaundice lasting about 10 weeks can be seen.[]

  • Hepatitis B

    Hepatitis B is a form of viral hepatitis, caused by the hepatitis B virus, a member of the Hepadnavirus family. It is estimated that worldwide, more than 350 million people have chronic hepatitis B virus infection. The course of the disease may be extremely variable, depending on the patient’s age and immune status.[…][]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[] […] hx of recent intensified drinking, RUQ pain, jaundice, leukocytosis, (PMN), modest elevation of AST and elevated alkaline phosphate ( resembles obstructive jaundice).[] Liver Function Tests: Normal Values & Changes Tests Normal Values Hepatocellular Jaundice Uncomplicated Obstructive Jaundice Bilirubin Direct Indirect 0.1-0.3 mg/dL 0.2-0.7[]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[] Conclusions Our patient’s case illustrates a rare DILI due to cefuroxime, presenting as prolonged cholestatic jaundice following “successful” therapeutic ERCP for an obstructing[] The laboratory findings were consistent with cholestatic jaundice. He had marked elevation of bilirubin and alkaline phosphatase.[]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[] ) can be caused by obstructive jaundice, a condition in which bile flow from the liver ducts is blocked.[] In 1851, Addison and Gull described the clinical picture of progressive obstructive jaundice in the absence of mechanical obstruction of the large bile ducts.[]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[] We present a rare case of a 52-year-old male who was admitted with obstructive jaundice and itchy skin.[] All other causes of cholestatic jaundice were ruled out.[]

  • Isoniazid Hepatitis

    Cholestatic jaundice caused by ethambutol. Br Med J 1986; 292: 866.[] Pyrrolizidine alkaloids typically have been associated with sinusoidal obstruction syndrome ( 69, 70, 71, 72, 73, 74 ).[] These products have been associated with an initial cholestatic hepatitis followed by prolonged jaundice ( 66, 67, 68 ).[]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[] The patient may also complain of pruritus (itching), as a result of bile accumulation, and pale stool with dark urine, from the obstructive jaundice.[] , jaundice, and abdominal pain caused by biliary obstruction.[]

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