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19 Possible Causes for Liver Biopsy showing Periportal Necrosis, Pruritus

  • Primary Sclerosing Cholangitis

    Jaundice and pruritus. Right upper quadrant abdominal pain. Fatigue, weight loss, fevers and sweats.[] Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[] A 45-year-old woman with the diagnosis of primary sclerosing cholangitis and ulcerative colitis admitted with the complaints of pruritus and jaundice.[]

  • Isoniazid Hepatitis

    Usually, the onset is abrupt, with chills, fever, rash, pruritus, arthralgia, headache, abdominal pain, anorexia, nausea and vomiting.[] Most clinicians use antihistamines such as diphenhydramine and hydroxyzine for symptomatic pruritus.[] On presentation, she complained of fatigue, nausea and dark urine but denied fever, rash or pruritus.[]

  • Hepatitis B

    A 52-year-old man complained of worsening appetite, abdominal distension, and pruritus.[] Respiratory, Thoracic And Mediastinal Disorders Rhinitis; influenza ; cough Nervous System Disorders Vertigo /dizziness; paresthesia 5 Skin And Subcutaneous Tissue Disorders Pruritus[] […] include erythema, pain, tenderness at the injection site, headache, malaise, agitation, amnesia, essential tremor, fatigue, light‐headedness or fainting, pyrexia, angioedema, pruritus[]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[] Intense pruritus can be itself an indication to liver transplantation, in extreme cases leading to suicide.[] Chronic pruritus. N Engl J Med 2013;368:1625-1634.[]

  • Viral Hepatitis

    During the past decade, NTX has been shown to be safe and effective in the treatment of pruritus associated with severe jaundice caused by severe and sometimes life-threatening[] It includes bed rest; isolation, if necessary; fluids; a low-fat, high-protein, high-calorie diet; special skin care if pruritus is present; emotional support; vitamins B[] […] associated with liver damage, such as: Fever, fatigue Loss of appetite Nausea, vomiting, abdominal pain Dark urine and/or pale colored stool Joint pain Jaundice Itching ( pruritus[]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[] References Bunchorntavakul C, Reddy KR: Pruritus in chronic cholestatic liver disease. Clin Liver Dis 2012;16: 331–346.[] Patients should be specifically asked about the presence of pruritus. In general, pruritus presents earlier in cases of intrahepatic cholestasis.[]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[] Cholestasis Features: Jaundice with pruritus – deposition of bile acids and bile salts in skin Malabsorption – bile salts do not enter S.I.[] Tell me about cholestatic hepatitis seen in unpredictable toxic injury Shows pruritus, hyperlipemia, xanthomata.[]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[] Fatigue Abdominal pain Joint pain Itching (pruritus) Jaundice An enlarged liver Abnormal blood vessels on the skin (spider angiomas) Nausea and vomiting Loss of appetite Skin[] Presentation Symptoms range from minor to severe can be acute or chronic fatigue abdominal pain joint pain pruritus skin rashes dark-colored urine amenorrhea in women - often[]

  • Hepatitis A

    Here we present a case of a 36-year-old female patient who developed severe pruritus and jaundice three weeks after initially uncomplicated hepatitis A.[] Features may include severe pruritus, diarrhoea, weight loss and malabsorption. However, they usually fully recover. Fulminant liver failure.[] Under these measures, pruritus and jaundice, as well as serum bilirubin levels improved gradually and after four plasmapheresis sessions we were able to discharge the patient[]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[] Pruritus (cholestasis). Breast swelling (gynaecomastia), testicular atrophy, loss of libido and amenorrhoea due to endocrine dysfunction.[] […] feeling generally unwell mild joint or muscle pains, usually these are worse in the morning low appetite (not feeling hungry) and weight loss feeling sick (nausea) itching (pruritus[]

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