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19 Possible Causes for Liver Biopsy showing Periportal Necrosis, Pruritus

  • Primary Sclerosing Cholangitis

    Jaundice and pruritus. Right upper quadrant abdominal pain. Fatigue, weight loss, fevers and sweats.[patient.info] Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[ncbi.nlm.nih.gov] A 45-year-old woman with the diagnosis of primary sclerosing cholangitis and ulcerative colitis admitted with the complaints of pruritus and jaundice.[ncbi.nlm.nih.gov]

  • Isoniazid Hepatitis

    Usually, the onset is abrupt, with chills, fever, rash, pruritus, arthralgia, headache, abdominal pain, anorexia, nausea and vomiting.[patient.info] Most clinicians use antihistamines such as diphenhydramine and hydroxyzine for symptomatic pruritus.[gi.org] On presentation, she complained of fatigue, nausea and dark urine but denied fever, rash or pruritus.[livertox.nih.gov]

  • Hepatitis B

    A 52-year-old man complained of worsening appetite, abdominal distension, and pruritus.[ncbi.nlm.nih.gov] Respiratory, Thoracic And Mediastinal Disorders Rhinitis; influenza ; cough Nervous System Disorders Vertigo /dizziness; paresthesia 5 Skin And Subcutaneous Tissue Disorders Pruritus[rxlist.com] […] include erythema, pain, tenderness at the injection site, headache, malaise, agitation, amnesia, essential tremor, fatigue, light‐headedness or fainting, pyrexia, angioedema, pruritus[doi.org]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] Intense pruritus can be itself an indication to liver transplantation, in extreme cases leading to suicide.[ncbi.nlm.nih.gov] Chronic pruritus. N Engl J Med 2013;368:1625-1634.[karger.com]

  • Viral Hepatitis

    During the past decade, NTX has been shown to be safe and effective in the treatment of pruritus associated with severe jaundice caused by severe and sometimes life-threatening[ncbi.nlm.nih.gov] It includes bed rest; isolation, if necessary; fluids; a low-fat, high-protein, high-calorie diet; special skin care if pruritus is present; emotional support; vitamins B[medical-dictionary.thefreedictionary.com] […] associated with liver damage, such as: Fever, fatigue Loss of appetite Nausea, vomiting, abdominal pain Dark urine and/or pale colored stool Joint pain Jaundice Itching ( pruritus[labtestsonline.org]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] References Bunchorntavakul C, Reddy KR: Pruritus in chronic cholestatic liver disease. Clin Liver Dis 2012;16: 331–346.[karger.com] Patients should be specifically asked about the presence of pruritus. In general, pruritus presents earlier in cases of intrahepatic cholestasis.[hepatitis.va.gov]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Cholestasis Features: Jaundice with pruritus – deposition of bile acids and bile salts in skin Malabsorption – bile salts do not enter S.I.[slideshare.net] Tell me about cholestatic hepatitis seen in unpredictable toxic injury Shows pruritus, hyperlipemia, xanthomata.[quizlet.com]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Fatigue Abdominal pain Joint pain Itching (pruritus) Jaundice An enlarged liver Abnormal blood vessels on the skin (spider angiomas) Nausea and vomiting Loss of appetite Skin[columbiasurgery.org] Presentation Symptoms range from minor to severe can be acute or chronic fatigue abdominal pain joint pain pruritus skin rashes dark-colored urine amenorrhea in women - often[step2.medbullets.com]

  • Hepatitis A

    Here we present a case of a 36-year-old female patient who developed severe pruritus and jaundice three weeks after initially uncomplicated hepatitis A.[ncbi.nlm.nih.gov] Features may include severe pruritus, diarrhoea, weight loss and malabsorption. However, they usually fully recover. Fulminant liver failure.[patient.info] Under these measures, pruritus and jaundice, as well as serum bilirubin levels improved gradually and after four plasmapheresis sessions we were able to discharge the patient[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Pruritus (cholestasis). Breast swelling (gynaecomastia), testicular atrophy, loss of libido and amenorrhoea due to endocrine dysfunction.[patient.info] […] feeling generally unwell mild joint or muscle pains, usually these are worse in the morning low appetite (not feeling hungry) and weight loss feeling sick (nausea) itching (pruritus[britishlivertrust.org.uk]

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