Diagnosis is often made following investigation of prolonged jaundice that is resistant to phototherapy and/or exchange transfusions, with abnormalities in liverenzyme tests … abnormally narrow, blocked, or absent. … In an Egyptian study, abnormally high levels of aflatoxin B1 and to a lesser extent aflatoxin B2 was found in liver tissue and blood of all neonates suffering from biliary … 
This abnormal buildup causes other symptoms of mitochondrial trifunctional protein deficiency. … Long-chain fatty acids may also build up and damage the liver, heart, and muscles. … During periods of fasting, fatty acids are also an important energy source for the liver and other tissues.
Severe aplastic anemia is a rare hematological disorder characterized by pancytopenia due to bone marrow failure, whereby depletion of pluripotent stem cells is commonly mediated by an autoimmune response. Accordingly, immunosuppression and hematopoietic stem cell transplantation constitute treatment options, with…
Liverenzymes called transaminases are indicators of liver damage and are usually increased, γ-GT another indicator of cholestasis is found mainly normal and bilirubin circulates … Genetic irregularities in the gene responsible for the regulating enzyme, HSD3B7, leads to an incomplete catalyzation and defective bile, which, in turn, induces liver disease … The exact genetic locus of the genes that encodes for the enzyme is 16p11.2-12 and various alterations to its sequence lead to an inactive enzyme.