Liver Fibrosis: Causes & Reasons

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Possible Causes for Liver Fibrosis

Systemic Scleroderma

[…] in idiopathic or radiation induced pulmonary fibrosis, liver fibrosis from viruses or toxins, kidney fibrosis from diabetes and other less common kidney diseases, and heart [sciencedaily.com]

fibrosis. [en.wikipedia.org]

[…] researchers proving that TGF-beta can block scarring may provide a major treatment advance for scarring-mediated organ dysfunction common to many diseases including lung fibrosis [sciencedaily.com]

Niemann-Pick Disease Type B

Biopsies were evaluated for fibrosis, SM accumulation, and macrophage infiltration by light and electron microscopy. [ncbi.nlm.nih.gov]

[…] and skin pathology Liver fibrosis in almost all patients. [ojrd.biomedcentral.com]

In the liver, the infiltration of foamy cells and ballooning of hepatocytes can lead to various degrees of hepatic fibrosis. [radiopaedia.org]

Gaucher Disease

Twenty years after starting treatment, the peripheral cell count and liver size were normal, whereas splenomegaly persisted. [ncbi.nlm.nih.gov]

[…] hepatomegaly: less marked than the degree of splenomegaly T2: hyperintense stellate areas representing inflammation and fibrosis 3 areas of hepatic ischemia skeletal system [radiopaedia.org]

Liver disease (but not Gaucher disease [GD]) was suspected and therefore a liver biopsy was performed. [touchoncology.com]

Visceral Leishmaniasis

The differential diagnosis includes liver fibrosis, abnormal blood flow due to splenic vein thrombosis or portal vein obstruction, and liver cirrhosis due to chronic viral [acgcasereports.gi.org]

However, no evidence of fibrosis is present. In the liver, the Kupffer cells are increased in size and number and infected with amastigote forms of Leishmania. [emedicine.com]

Liver Cirrhosis

Keywords: Liver fibrosis, Cirrhosis, Regression, Hepatic repair complex INTRODUCTION Fibrosis is an integral component of chronic liver disease. [ncbi.nlm.nih.gov]

Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease. [ncbi.nlm.nih.gov]

Liver biopsy is necessary for diagnosis and staging of liver fibrosis. [dx.doi.org]

Portal Cirrhosis

Clinical findings Ascites, increased infections including pneumonia, poor self-care, hepatic encephalopathy, liver fibrosis leading to portal hypertension, and oesophageal [medical-dictionary.thefreedictionary.com]

[…] of liver (K76.1) cirrhosis (of liver) with toxic liver disease (K71.7) congenital cirrhosis (of liver) (P78.81) pigmentary cirrhosis (of liver) (E83.110) Fibrosis and cirrhosis [icd10data.com]

Type 1 Excludes jaundice NOS ( R17 ) Diseases of liver K74 ICD-10-CM Diagnosis Code K74 Fibrosis and cirrhosis of liver 2016 2017 2018 2019 Non-Billable/Non-Specific Code [icd10data.com]

Alcoholic Liver Disease

Three different testing alternatives were studied: a single liver biopsy; annual Enhanced liver fibrosis (ELF™) followed by liver stiffness measurement (LSM) imaging as a [ncbi.nlm.nih.gov]

[…] elastography), and 6 indirect marker tests in detection of advanced liver fibrosis (Kleiner stage ≥F3). [ncbi.nlm.nih.gov]

Chronic alcohol abuse leads to liver damage, liver inflammation, fibrosis and hepatocellular carcinoma. [ncbi.nlm.nih.gov]

Macronodular Cirrhosis

Liver biopsy is necessary for diagnosis and staging of liver fibrosis. [pubs.rsna.org]

[…] and stage 3 liver fibrosis. [ncbi.nlm.nih.gov]

Next Steps Evidence Creator Insights Advice Low fibrosis scores may be appropriate candidates for medical management and may not require liver biopsy if FIB-4 scores continue [mdcalc.com]

Cryptogenic Cirrhosis

Therefore, our aim was to assess recurrence of liver fibrosis in patients transplanted for NASH versus CC after OLT. [ncbi.nlm.nih.gov]

1 Lysosomal acid lipase activity and liver fibrosis in the clinical continuum of non-alcoholic fatty liver disease. 61 31392821 2019 2 Metastatic cholangiocarcinoma in a patient [malacards.org]

The scar tissue forms fibrous masses (a condition called liver fibrosis ) and, over time, causes degradation of liver function eventually leading to complete liver failure [liverbasics.com]

Gaucher Disease Type 1

[…] hepatomegaly: less marked than the degree of splenomegaly T2: hyperintense stellate areas representing inflammation and fibrosis 3 areas of hepatic ischemia skeletal system [radiopaedia.org]

Liver disease (but not Gaucher disease [GD]) was suspected and therefore a liver biopsy was performed. [touchoncology.com]

Hepatomegaly affects 60-80% of individuals with GD type 1 but the development of fibrosis, cirrhosis or liver failure are rare [2,3]. [clinmedjournals.org]

Fatty Liver

If untreated, liver fibrosis may progress to cirrhosis of the liver, liver failure, and liver cancer. [radiologyinfo.org]

fibrosis in nonalcoholic fatty liver disease. [ncbi.nlm.nih.gov]

Wong VW, Vergniol J, Wong GL et al (2010) Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. [doi.org]

Chronic Hepatitis C

[…] and the stages of liver fibrosis (r=0.026, p=0.923). [ncbi.nlm.nih.gov]

Liver fibrosis was assessed by transient elastography. [ncbi.nlm.nih.gov]

Congenital Hepatic Fibrosis

Key words: liver fibrosis, living donor liver transplantation, congenital hepatic fibrosis, chronic liver failure [scopemed.org]

A family with clear evidence of concomitant congenital hepatic fibrosis, polycystic liver and adult-type polycystic kidney is reported. [ncbi.nlm.nih.gov]

RESULTS: Congenital hepatic fibrosis liver tissue homogenates had higher levels of thrombospondin-1 and transforming growth factor-beta1 protein than in normal livers. [ncbi.nlm.nih.gov]

Hepatopathy

If untreated, liver fibrosis may progress to cirrhosis of the liver, liver failure, and liver cancer. [radiologyinfo.org]

[…] and stage 3 liver fibrosis. [ncbi.nlm.nih.gov]

[…] as liver fibrosis. [ncbi.nlm.nih.gov]

Chronic Hepatopathy

fibrosis in HCV-associated chronic liver disease (HCV-CLD). 145 Egyptian HCV-CLD patients were divided according to Metavir fibrosis scores. [ncbi.nlm.nih.gov]

These findings indicate that PlGF plays an important role in liver fibrosis-associated angiogenesis and that blockage of PlGF could be an effective strategy for chronic liver [ncbi.nlm.nih.gov]

There was significantly greater diagnostic accuracy for liver fibrosis stage ≥4 with MRE than that with fibrosis markers. [ncbi.nlm.nih.gov]

Congenital Liver Cirrhosis

One such organ is the liver, in which fibrosis develops in response to elevated pressure within the veins. [sciencedaily.com]

His lecture titled "Mechanisms of the Progression and Regression of Liver Fibrosis" provided important advice for developing antifibrotic agents. [books.google.de]

[…] cirrhosis Postnecrotic cirrhosis Septal fibrosis of liver Toxic cirrhosis Toxic liver disease w cirrhosis, w fibrosis Toxic liver disease with cirrhosis, with fibrosis Toxic [icd9data.com]

Liver Fibrosis

Abstract Liver fibrosis is a wound-healing response generated against an insult to the liver that causes liver injury. [ncbi.nlm.nih.gov]

Thus, noninvasive methods for assessing liver fibrosis are of great clinical interest. [ncbi.nlm.nih.gov]

Greater knowledge of the role of the Wnt signaling pathway in liver fibrosis could improve understanding of the liver fibrosis pathogenesis. [ncbi.nlm.nih.gov]

Alcoholic Fatty Liver

If untreated, liver fibrosis may progress to cirrhosis of the liver, liver failure, and liver cancer. [radiologyinfo.org]

BACKGROUND AND AIM: The fibrosis stage of liver is associated with the long-term outcomes in patients with non-alcoholic fatty liver disease (NAFLD). [ncbi.nlm.nih.gov]

FIBROSIS In response to inflammatory cytokines and liver injury, collagen deposition occurs in the liver and results in fibrosis. [aafp.org]

Cardiac Cirrhosis

[…] injury is usually self-limiting when it affects the normal liver, but more serious changes may occur when the liver has been previously damaged 10 Congestive liver fibrosis [powershow.com]

The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. [pubfacts.com]

For the remainder of this chapter, the term cardiac cirrhosis will be used to mean congestive hepatopathy with or without liver fibrosis. Cardiac cirrhosis. [emedicine.medscape.com]

Cholesterol Ester Storage Disease

In detail, CESD causes liver enlargement, possibly followed by liver fibrosis and cirrhosis, and atherosclerosis, which predisposes for coronary heart disease and stroke. [symptoma.com]

Late onset – sometimes called Cholesteryl Ester Storage Disease (CESD), affects 25 individuals per million births and may lead to liver fibrosis, cirrhosis, liver failure [cuh.nhs.uk]

fibrosis, cirrhosis, liver failure and death. [cuh.nhs.uk]

Presinusoidal Portal Hypertension

“Noncirrhotic Presinusoidal Portal Hypertension Is Common in Cystic Fibrosis-associated Liver Disease.” Hepatology 53 (3): 1064–1065. [biblio.ugent.be]

ITEM METADATA RECORD Title: Noncirrhotic presinusoidal portal hypertension is common in cystic fibrosis-associated liver disease Authors: Witters, Peter × Libbrecht, Louis [lirias.kuleuven.be]

fibrosis. [elsevier.es]

Passive Congestion of the Liver

For the remainder of this chapter, the term cardiac cirrhosis will be used to mean congestive hepatopathy with or without liver fibrosis. Cardiac cirrhosis. [emedicine.medscape.com]

The pattern of fibrosis is different from cirrhosis due to alcoholic liver disease, since fibrosis in that condition bridges from portal to portal. [uaz.edu.mx]

A liver biopsy specimen showed typical central congestive fibrosis. The pericentral hepatocytes were replaced by connective tissue. [annals.org]

Chronic Hepatitis

BACKGROUND: Evaluation of liver fibrosis is important to assess prognosis and guide the treatment for chronic hepatitis B. [ncbi.nlm.nih.gov]

Significant liver fibrosis was found in 24/70 patients. [ncbi.nlm.nih.gov]

Serum YKL-40 is a feasible biomarker of liver fibrosis in chronic hepatitis B patients. [ncbi.nlm.nih.gov]

Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

Severe liver dysfunction in an infant with cystic fibrosis masquerading as metabolic liver disease. [ijpmonline.org]

Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis. {ECO:0000269 PubMed:22607940}. [genecards.org]

Minor illness exacerbates deterioration of liver failure. [orpha.net]

Primary Sclerosing Cholangitis

Enhanced liver fibrosis (ELF) test was previously reported to predict outcome in PSC. [ncbi.nlm.nih.gov]

The progression of liver fibrosis in an individual patient is difficult to predict and may vary from a relatively benign, nonprogressive form to a rapidly progressive form [ncbi.nlm.nih.gov]

INTRODUCTION: Primary sclerosing cholangitis (PSC) is a progressive inflammatory liver disease characterised by relentless liver fibrosis and a high unmet need for new therapies [ncbi.nlm.nih.gov]

Senior-Løken Syndrome

We present two sisters with nephronophthisis and pigmentary retinopathy (Senior-Loken syndrome) and associated liver fibrosis. [ncbi.nlm.nih.gov]

Our report underlines the need to investigate liver disorders in all patients with nephronophthisis and the existence of liver fibrosis as an element of the hereditary ‘nephronophthisis [karger.com]

Systemic associations of this syndrome include sensorineural hearing loss, liver fibrosis or cerebral vermis hypoplasia. [ncbi.nlm.nih.gov]

Secondary Biliary Cirrhosis

Cystic fibrosis and liver disease The Leeds Method of Management. April, 2008. Cystic fibrosis and liver disease [online]. [cfmedicine.com]

ICD-10-CM Codes › K00-K95 Diseases of the digestive system › K70-K77 Diseases of liver › K74- Fibrosis and cirrhosis of liver › Secondary biliary cirrhosis 2016 2017 2018 [icd10data.com]

Some cystic fibrosis patients have undergone liver transplantation. [radiology-information.blogspot.com]

Glycogen Storage Disease Type 9

In the patients described here, this genotype is associated with development of liver fibrosis. [ncbi.nlm.nih.gov]

Therefore, defect in PHKG2 should be considered in patients with suspected glycogenosis associated with significant liver fibrosis and cirrhosis. [ncbi.nlm.nih.gov]

Conditions such as renal tubular acidosis, splenomegaly, liver fibrosis and cirrhosis, and polycystic ovary syndrome have been described. [symptoma.com]

Chronic Hepatic Schistosomiasis

Young patient with severe liver fibrosis and portal hypertension. [atlasofscience.org]

[…] hepatic fibrosis, which may determine therapy and prognosis Ultrasonographic Findings • Grayscale ultrasound Hepatomegaly in early stages Atrophic liver in late stage (fibrosis [radiologykey.com]

Inducible nitric oxide synthase expression (iNOS) in chronic viral hepatitis and its correlation with liver fibrosis. [pacificejournals.com]

Hepatitis C

KEYWORDS: HCV genotype; Hepatitis C virus (HCV); advanced liver fibrosis; adverse event; antiviral regimen; case reports; cirrhosis; dasabuvir; decreased kidney function; [ncbi.nlm.nih.gov]

12 to 24 weeks, depending on degree of liver fibrosis and history of prior treatment Simeprevir can cause anemia and photosensitivity. [msdmanuals.com]

Those with a lesser degree of liver fibrosis typically are not at increased risk for developing liver cancer. [newsnetwork.mayoclinic.org]