Liver Fibrosis: Causes & Reasons

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Possible Causes for Liver Fibrosis

Systemic Scleroderma

[…] in idiopathic or radiation induced pulmonary fibrosis, liver fibrosis from viruses or toxins, kidney fibrosis from diabetes and other less common kidney diseases, and heart [sciencedaily.com]

fibrosis. [en.wikipedia.org]

[…] researchers proving that TGF-beta can block scarring may provide a major treatment advance for scarring-mediated organ dysfunction common to many diseases including lung fibrosis [sciencedaily.com]

Niemann-Pick Disease Type B

Biopsies were evaluated for fibrosis, SM accumulation, and macrophage infiltration by light and electron microscopy. [ncbi.nlm.nih.gov]

[…] and skin pathology Liver fibrosis in almost all patients. [ojrd.biomedcentral.com]

In the liver, the infiltration of foamy cells and ballooning of hepatocytes can lead to various degrees of hepatic fibrosis. [radiopaedia.org]

Gaucher Disease

Twenty years after starting treatment, the peripheral cell count and liver size were normal, whereas splenomegaly persisted. [ncbi.nlm.nih.gov]

[…] hepatomegaly: less marked than the degree of splenomegaly T2: hyperintense stellate areas representing inflammation and fibrosis 3 areas of hepatic ischemia skeletal system [radiopaedia.org]

Liver disease (but not Gaucher disease [GD]) was suspected and therefore a liver biopsy was performed. [touchoncology.com]

Visceral Leishmaniasis

The differential diagnosis includes liver fibrosis, abnormal blood flow due to splenic vein thrombosis or portal vein obstruction, and liver cirrhosis due to chronic viral [acgcasereports.gi.org]

However, no evidence of fibrosis is present. In the liver, the Kupffer cells are increased in size and number and infected with amastigote forms of Leishmania. [emedicine.com]

Gaucher Disease Type 1

[…] hepatomegaly: less marked than the degree of splenomegaly T2: hyperintense stellate areas representing inflammation and fibrosis 3 areas of hepatic ischemia skeletal system [radiopaedia.org]

Liver disease (but not Gaucher disease [GD]) was suspected and therefore a liver biopsy was performed. [touchoncology.com]

Hepatomegaly affects 60-80% of individuals with GD type 1 but the development of fibrosis, cirrhosis or liver failure are rare [2,3]. [clinmedjournals.org]

Liver Cirrhosis

Keywords: Liver fibrosis, Cirrhosis, Regression, Hepatic repair complex INTRODUCTION Fibrosis is an integral component of chronic liver disease. [ncbi.nlm.nih.gov]

BACKGROUND/PURPOSE: Metabolic risk factors are associated with liver fibrosis. [ncbi.nlm.nih.gov]

Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease. [ncbi.nlm.nih.gov]

Portal Cirrhosis

Clinical findings Ascites, increased infections including pneumonia, poor self-care, hepatic encephalopathy, liver fibrosis leading to portal hypertension, and oesophageal [medical-dictionary.thefreedictionary.com]

[…] of liver fibrosis that leads to shunting of the portal and arterial blood supply directly into hepatic outflow through the central veins with compromised exchange between [accesspharmacy.mhmedical.com]

[…] of liver (K76.1) cirrhosis (of liver) with toxic liver disease (K71.7) congenital cirrhosis (of liver) (P78.81) pigmentary cirrhosis (of liver) (E83.110) Fibrosis and cirrhosis [icd10data.com]

Alcoholic Liver Disease

Chronic alcohol abuse leads to liver damage, liver inflammation, fibrosis and hepatocellular carcinoma. [ncbi.nlm.nih.gov]

Three different testing alternatives were studied: a single liver biopsy; annual Enhanced liver fibrosis (ELF™) followed by liver stiffness measurement (LSM) imaging as a [ncbi.nlm.nih.gov]

CONCLUSIONS: TE has excellent diagnostic value for liver fibrosis in alcoholic liver disease. [ncbi.nlm.nih.gov]

Macronodular Cirrhosis

Cirrhosis is end stage fibrosis of the liver. General Cirrhosis is stage 4 (Laennec). [librepathology.org]

Liver biopsy is necessary for diagnosis and staging of liver fibrosis. [pubs.rsna.org]

[…] and stage 3 liver fibrosis. [ncbi.nlm.nih.gov]

Cryptogenic Cirrhosis

Therefore, our aim was to assess recurrence of liver fibrosis in patients transplanted for NASH versus CC after OLT. [ncbi.nlm.nih.gov]

1 Lysosomal acid lipase activity and liver fibrosis in the clinical continuum of non-alcoholic fatty liver disease. 61 31392821 2019 2 Metastatic cholangiocarcinoma in a patient [malacards.org]

The scar tissue forms fibrous masses (a condition called liver fibrosis ) and, over time, causes degradation of liver function eventually leading to complete liver failure [liverbasics.com]

Fatty Liver

fibrosis in nonalcoholic fatty liver disease. [ncbi.nlm.nih.gov]

If untreated, liver fibrosis may progress to cirrhosis of the liver, liver failure, and liver cancer. [radiologyinfo.org]

[…] the enhanced liver fibrosis (ELF) blood test Offer children with NAFLD screening for advanced liver fibrosis every two years using the ELF blood test There has been a lack [doi.org]

Primary Sclerosing Cholangitis

Enhanced liver fibrosis (ELF) test was previously reported to predict outcome in PSC. [ncbi.nlm.nih.gov]

The progression of liver fibrosis in an individual patient is difficult to predict and may vary from a relatively benign, nonprogressive form to a rapidly progressive form [ncbi.nlm.nih.gov]

INTRODUCTION: Primary sclerosing cholangitis (PSC) is a progressive inflammatory liver disease characterised by relentless liver fibrosis and a high unmet need for new therapies [ncbi.nlm.nih.gov]

Chronic Hepatitis C

Liver fibrosis was assessed by transient elastography. [ncbi.nlm.nih.gov]

US-based method for assessing liver fibrosis in HCV-related chronic liver disease patients with good diagnostic performance comparable to that of liver biopsy and TE. [ncbi.nlm.nih.gov]

Congenital Hepatic Fibrosis

Key words: liver fibrosis, living donor liver transplantation, congenital hepatic fibrosis, chronic liver failure [scopemed.org]

RESULTS: Congenital hepatic fibrosis liver tissue homogenates had higher levels of thrombospondin-1 and transforming growth factor-beta1 protein than in normal livers. [ncbi.nlm.nih.gov]

Liver fibrosis is a wound healing response in which collagen accumulates in the liver due to an imbalance between extracellular matrix synthesis and degradation. [ncbi.nlm.nih.gov]

Hepatopathy

If untreated, liver fibrosis may progress to cirrhosis of the liver, liver failure, and liver cancer. [radiologyinfo.org]

[…] as liver fibrosis. [ncbi.nlm.nih.gov]

[…] and stage 3 liver fibrosis. [ncbi.nlm.nih.gov]

Chronic Liver Disease

fibrosis in HCV-associated chronic liver disease (HCV-CLD). 145 Egyptian HCV-CLD patients were divided according to Metavir fibrosis scores. [ncbi.nlm.nih.gov]

There was significantly greater diagnostic accuracy for liver fibrosis stage ≥4 with MRE than that with fibrosis markers. [ncbi.nlm.nih.gov]

BACKGROUND/PURPOSE: Metabolic risk factors are associated with liver fibrosis. [ncbi.nlm.nih.gov]

Toxic Liver Disease

[…] and cirrhosis of liver Excludes: alcoholic fibrosis of liver ( K70.2 ) cardiac sclerosis of liver ( K76.1 ) cirrhosis (of liver): · alcoholic ( K70.3 ) · congenital ( P78.8 [apps.who.int]

Blood clotting more quickly than normal can also be related to cirrhosis or liver fibrosis. 5. [powerofpositivity.com]

Code K70 K70 Alcoholic liver disease K70.0 Alcoholic fatty liver K70.1 Alcoholic hepatitis K70.10 …… without ascites K70.11 …… with ascites K70.2 Alcoholic fibrosis and sclerosis [icd10data.com]

Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

Severe liver dysfunction in an infant with cystic fibrosis masquerading as metabolic liver disease. [ijpmonline.org]

Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis. {ECO:0000269 PubMed:22607940}. [genecards.org]

Minor illness exacerbates deterioration of liver failure. [orpha.net]

Congenital Liver Cirrhosis

His lecture titled "Mechanisms of the Progression and Regression of Liver Fibrosis" provided important advice for developing antifibrotic agents. [books.google.de]

One such organ is the liver, in which fibrosis develops in response to elevated pressure within the veins. [sciencedaily.com]

[…] cirrhosis Postnecrotic cirrhosis Septal fibrosis of liver Toxic cirrhosis Toxic liver disease w cirrhosis, w fibrosis Toxic liver disease with cirrhosis, with fibrosis Toxic [icd9data.com]

Hemochromatosis

CONCLUSIONS: Our findings indicate that GNPAT rs11558492 is not a major modifier of iron status and is not associated with liver fibrosis in HFE-HH patients. [ncbi.nlm.nih.gov]

METHODS: Liver fibrosis was histologically assessed by Ishak score. [ncbi.nlm.nih.gov]

This test can also determine whether or not you have liver fibrosis. [hopkinsmedicine.org]

Liver Fibrosis

Greater knowledge of the role of the Wnt signaling pathway in liver fibrosis could improve understanding of the liver fibrosis pathogenesis. [ncbi.nlm.nih.gov]

Oroxylin A for the treatment of liver fibrosis. [ncbi.nlm.nih.gov]

Thus, noninvasive methods for assessing liver fibrosis are of great clinical interest. [ncbi.nlm.nih.gov]

Alcoholic Fatty Liver

If untreated, liver fibrosis may progress to cirrhosis of the liver, liver failure, and liver cancer. [radiologyinfo.org]

BACKGROUND AND AIM: The fibrosis stage of liver is associated with the long-term outcomes in patients with non-alcoholic fatty liver disease (NAFLD). [ncbi.nlm.nih.gov]

FIBROSIS In response to inflammatory cytokines and liver injury, collagen deposition occurs in the liver and results in fibrosis. [aafp.org]

Hepatitis C

12 to 24 weeks, depending on degree of liver fibrosis and history of prior treatment Simeprevir can cause anemia and photosensitivity. [msdmanuals.com]

Those with a lesser degree of liver fibrosis typically are not at increased risk for developing liver cancer. [newsnetwork.mayoclinic.org]

fibrosis on liver biopsy, HIV or HBV coinfection, and comordid conditions. [medsci.org]

Presinusoidal Portal Hypertension

“Noncirrhotic Presinusoidal Portal Hypertension Is Common in Cystic Fibrosis-associated Liver Disease.” Hepatology 53 (3): 1064–1065. [biblio.ugent.be]

fibrosis. [elsevier.es]

Noncirrhotic presinusoidal portal hypertension is common in cystic fibrosis-associated liver disease. HEPATOLOGY. 2011;53(3):1064–5. [biblio.ugent.be]

Cholesterol Ester Storage Disease

In detail, CESD causes liver enlargement, possibly followed by liver fibrosis and cirrhosis, and atherosclerosis, which predisposes for coronary heart disease and stroke. [symptoma.com]

Late onset – sometimes called Cholesteryl Ester Storage Disease (CESD), affects 25 individuals per million births and may lead to liver fibrosis, cirrhosis, liver failure [cuh.nhs.uk]

fibrosis, cirrhosis, liver failure and death. [cuh.nhs.uk]

Cardiac Cirrhosis

[…] injury is usually self-limiting when it affects the normal liver, but more serious changes may occur when the liver has been previously damaged 10 Congestive liver fibrosis [powershow.com]

The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. [pubfacts.com]

For the remainder of this chapter, the term cardiac cirrhosis will be used to mean congestive hepatopathy with or without liver fibrosis. Cardiac cirrhosis. [emedicine.medscape.com]

Passive Congestion of the Liver

For the remainder of this chapter, the term cardiac cirrhosis will be used to mean congestive hepatopathy with or without liver fibrosis. Cardiac cirrhosis. [emedicine.medscape.com]

The pattern of fibrosis is different from cirrhosis due to alcoholic liver disease, since fibrosis in that condition bridges from portal to portal. [uaz.edu.mx]

liver fibrosis; Central hepatic veins are pale spots, nutmeg liver Liver: Passive Congestion: Gross close-up excellent nutmeg appearance Passive Congestion: Gross split [wikidoc.org]

Primary Biliary Cirrhosis

The diagnostic value of LS and the four indicators of liver fibrosis in determining liver cirrhosis degree with PBC, whether used alone or in combination, were analyzed by [ncbi.nlm.nih.gov]

Additionally, MRI using diffusion-weighted imaging with apparent diffusion coefficient measurements provides non-invasive assessment of the stage of liver fibrosis. [ncbi.nlm.nih.gov]

[…] made in this trial with the use of transient elastography and enhanced liver fibrosis scores. [nejm.org]

Glycogen Storage Disease Type 9

In the patients described here, this genotype is associated with development of liver fibrosis. [ncbi.nlm.nih.gov]

Therefore, defect in PHKG2 should be considered in patients with suspected glycogenosis associated with significant liver fibrosis and cirrhosis. [ncbi.nlm.nih.gov]

Conditions such as renal tubular acidosis, splenomegaly, liver fibrosis and cirrhosis, and polycystic ovary syndrome have been described. [symptoma.com]

Drug-Induced Toxic Hepatitis

[…] hepatitis Toxic liver disease with cirrhosis, with fibrosis Toxic liver disease with fibrosis and cirrhosis of liver Toxic liver disease with hepatic necrosis Toxic liver [icd9data.com]

[…] classified K71.7 Toxic liver disease with fibrosis and cirrhosis of liver K71.8 Toxic liver disease with other disorders of liver K71.9 Toxic liver disease, unspecified K72 [icd10data.com]