Liver Function Impairment: Causes & Reasons

Possible Causes for Liver Function Impairment

Guanidine, a drug that increases the release of acetylcholine, often lessens symptoms but may inhibit the bone marrow’s production of blood cells and impair liver function [merckmanuals.com]

Mitochondrial Complex 3 Deficiency Nuclear Type 1

function Absent speech Glutaric aciduria Apathy Pigmentary retinopathy Neurological speech impairment Respiratory insufficiency Flexion contracture Scoliosis Feeding difficulties [mendelian.co]

Blindness Mental deterioration Leukodystrophy Delayed speech and language development Decreased activity of the pyruvate dehydrogenase complex Abnormality of movement Decreased liver [mendelian.co]

Ornithine Transcarbamylase Deficiency

Some UCD patients have undergone liver transplantation due to the severe impairment of liver function during their first metabolic crisis, and before the diagnosis was definitively [journals.plos.org]

Mitochondrial abnormalities within the liver of patients with OTCD has been previously demonstrated[15], and hyperammonemia itself disrupts the function of mitochondria[16 [wjgnet.com]

In ALF associated with metabolic diseases, there is a lack of consensus criteria for liver transplantation [ 12 ]. [journals.plos.org]

Visceral Leishmaniasis

If visceral leishmaniasis progresses, it attacks the immune system and affects the bone marrow and internal organs (including enlargement and impaired function of the spleen [unitingtocombatntds.org]

[…] and liver), as well as causing irregular bouts of fever, substantial weight loss and anaemia. [unitingtocombatntds.org]

Cadmium Poisoning

In addition, like nickel, cadmium can replace zinc in critical metabolic pathways, impairing immune system function. [coreonehealth.com]

Levels of other fats may be adversely affected if liver function is impaired by cadmium toxicity. [arltma.com]

Increased exposures to cadmium damages the liver and kidneys, softens bone, and even causes a loss of sense of smell. [coreonehealth.com]

Selenosis

When glutathione production is low, detoxification in the liver is seriously impaired. [drlwilson.com]

Thus, this function of selenium is also a critical one. 3. Heavy metal detoxification. [drlwilson.com]

Venous Air Embolism

Anesth Analg. 2005 Oct;101(4):966-70, table of contents. Author information 1 Department of Anesthesia and Pain Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, C.P.O. Box 8044, Seoul 120-752, Korea. koobn@yumc.yonsei.ac.kr Abstract The Cavitron Ultrasonic Surgical Aspirator (CUSA) is an[…] [ncbi.nlm.nih.gov]

Staphylococcus Aureus Infection

Result Filters Abstract Staphylococcus aureus strains that produce Panton-Valentine leukocidin are known to cause community infections. We describe an outbreak of skin abscesses caused by Panton-Valentine leukocidin-producing methicillin-susceptible S. aureus (clonal complex 121) in a professional rugby team in[…] [ncbi.nlm.nih.gov]

Clostridium Perfringens Infection

Clostridium perfringens y Clostridium difficile como agentes etiológicos de diarrea nosocomial asociada a antibióticos en niños costarricenses [1] Universidad de Costa Rica Universidad de Costa Rica Hospital, Costa Rica Localización: Revista Biomédica, ISSN-e 0188-493X, Vol. 18, Nº. 2, 2007, págs. 81-87 Idioma: español[…] [dialnet.unirioja.es]

Chlorinated Naphthalene Poisoning

Effects of long-term or repeated exposure The substance may have effects on the liver. This may result in impaired functions. [ilo.org]

Chlorphenol Poisoning

liver functional state. [pubmed.ncbi.nlm.nih.gov]

[…] aminotransferase, aspartate aminotransferase) and cholestasis (alkaline phosphatase), intensified lipid peroxidation, depressed activity of antioxidant enzymes (catalase), impaired [pubmed.ncbi.nlm.nih.gov]

Daunorubicin Poisoning

Impairment of liver function requires a dose reduction, which is based on the serum bilirubin level. Impaired renal function can also induce an increase in toxicity. [minclinic.ru]

Liver and renal function Daunorubicin hydrochloride is metabolized predominantly in the liver and is excreted via the bile. [minclinic.ru]

To avoid complications monitoring of the liver function before starting treatment with daunorubicin hydrochloride is recommended. [minclinic.ru]

Toxic Liver Disease

In hepatic encephalopathy, toxins are not removed because liver function is impaired. [merckmanuals.com]

Isn’t Functioning Optimally If you have recently noticed any of the symptoms listed below, you could be suffering from impaired liver function. [draxe.com]

However, it is a condition that requires attention and investigation may determine impairment of liver function to be a contributing factor. [globalhealingcenter.com]

Erythema Palmare Hereditarium

If your liver function is impaired, palmar erythema may appear if you’re taking amiodarone (Cordarone), cholestyramine (Questran), or gemfibrozil (Lopid). [healthline.com]

[…] is functioning normally, or amiodarone, cholestyramine and gemfibrozil if there is liver impairment Other: including infections, atopic dermatitis, primary or metastatic [dermnetnz.org]

For example, if your liver function is normal, drugs like topiramate (Topamax) and albuterol (Proventil) may cause symptoms. [healthline.com]

Aggressive Systemic Mastocytosis

Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function [ncbi.nlm.nih.gov]

[…] of liver function as becomes evident from portal hypertension or ascites Palpable splenomegaly is detected and is associated with hypersplenism Patients suffer pathological [symptoma.com]

The organ-systems most frequently affected are the bone marrow, skeletal system, liver, spleen, and the gastrointestinal tract. [ncbi.nlm.nih.gov]

Tyrosinemia Type 1

Impaired cognitive functioning in patients with tyrosinemia type I receiving nitisinone. J Pediatr., 164 (2014), pp. 398-401 [11.] D. Devictor, P. Tissieres, M. [elsevier.es]

Acute liver failure in children. Clin Res Hepatol Gastroenterol., 35 (2011), pp. 430-437 [12.] C. de Laet, C. Dionisi-Vici, J.V. Leonard, P. McKiernan, G. Mitchell, H.O. [elsevier.es]

Disulfiram Poisoning

Extreme caution and close monitoring is advised if used in patients with liver impairment. [drugs.com]

Hepatic toxicity has occurred in patient with and without prior history of abnormal liver function. [drugs.com]

Autosomal Dominant Alport Syndrome

We have mapped the disease-causing gene to the long arm of chromosome 22 in an extended Israeli family with Fechtner syndrome plus impaired liver functions and hypercholesterolemia [ncbi.nlm.nih.gov]

Portal Cirrhosis

liver function): Impaired protein synthesis (leukonychia [white nails], ascites, bruising) Impaired biliary excretion (jaundice, pruritus) Impaired nitrogen metabolism (hepatic [pathologyoutlines.com]

[…] of liver function, and ultimately producing the typical hobnail liver — called also portal cirrhosis Learn More about Laennec's cirrhosis Cite this Entry “Laennec's cirrhosis [merriam-webster.com]

Subsequent hepatic repair mechanisms lead to fibrosis and abnormal tissue architecture, which impair liver function. [amboss.com]

Cobalt Poisoning

Necrosis at high levels of Cr (VI) Kidney Co excreted by the liver Can impair liver function Respiratory System Asthma Shortness of breath Asthma Shortness of breath Nervous [mjalterlaw.com]

Symptoms of Chromium poisoning may include: Acute renal failure GI hemorrhage Impaired liver function Increased risk of cancers Legal Rights For DePuy Patients With Chromium [nursinghomelawcenter.org]

[…] expression Cr (VI) Localized tissue around the implant Hypersensitivity Inflammation Infiltration of lymphocytes Hypersensitivity Inflammation Infiltration of lymphocytes Liver [mjalterlaw.com]

Ornithine Aspartate Poisoning

If liver function is substantially impaired, the infusion rate must be adjusted to individual patient in order to prevent nausea and vomiting. [mims.com]

Achard Syndrome

Patient with hepatic impairment: In the presence of liver function impairment the half life of Hi dac is prolonged and a reduction of daily dosage may be required. [medicinesfaq.com]

Special Warning Patient with renal impairment: Hi dac should be administered with caution to patients with impaired renal function and to those with bleeding disorders, epilepsy [medicinesfaq.com]

Macronodular Cirrhosis

Impaired liver function. Hepatic failure. Hepatocellular carcinoma. [brainscape.com]

liver function. [icdlist.com]

Combined Oxidative Phosphorylation Defect Type 37

Decreased liver function MedGen UID: 65430 •Concept ID: C0232744 • Finding Reduced ability of the liver to perform its functions. [ncbi.nlm.nih.gov]

function Feeding difficulties Macrovesicular hepatic steatosis Abnormality of the eye Chorioretinal hyperpigmentation Optic atrophy Visual impairment Abnormality of the genitourinary [ncbi.nlm.nih.gov]

Feeding difficulties MedGen UID: 65429 •Concept ID: C0232466 • Finding Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow [ncbi.nlm.nih.gov]

Lysine Malabsorption Syndrome

[…] weakness, impaired immune function, and progressively brittle bones that are prone to fracture (osteoporosis). [medlineplus.gov]

People with lysinuric protein intolerance have features associated with protein intolerance, including an enlarged liver and spleen (hepatosplenomegaly), short stature, muscle [medlineplus.gov]

Cardiac Cirrhosis

[…] non alcoholic liver disease accumulation of fat in the liver cells which eventually lead to formation of fibrous tissues and impaired liver function cirrhosis characterized [quizlet.com]

Impaired liver function. Failure in uptake or conjugation. Deficiencies in uptake are uncommon and are generally due to genetic disorders. [mediktor.com]

Spider Naevus

[Facial skin lesions in male patients with liver cirrhosis: role of serum sex hormones and correlation with impaired liver function]. [termedia.pl]

"Spider angiomas in patients with liver cirrhosis: role of alcoholism and impaired liver function". Scand. J. [en.wikipedia.org]

Spider angiomas in patients with liver cirrhosis: role of alcoholism and impaired liver function. Scand J Gastroenterol 1999; 34: 520-3 9. Iino S. [jpgmonline.com]

Bantu Siderosis

Symptoms Iron deposits in liver Liver cirrhosis Impaired liver function Enlarged liver Iron deposits in spleen Iron deposits in bone marrow Causes The exact cause of Bantu [checkorphan.org]

Etoricoxib Toxicity

Mercury poisoning can also lead to chronic injuries to peripheral nerves, and impairment of liver function [11,18]. [ncbi.nlm.nih.gov]

Liver Fibrosis

impair blood flow and cause disruption of liver functioning. [liverbasics.com]

Over time, these progressive conditions can lead to liver function impairment, liver cancer and the need for a liver transplant. [hepmag.com]

While the first antiretrovirals, which became available in particular D-drugs (especially didanosine and stavudine) and unboosted protease inhibitors, may impair liver function [ncbi.nlm.nih.gov]