Localized Scleroderma: Causes & Reasons

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Possible Causes for Localized Scleroderma

Systemic Scleroderma

Localized scleroderma affects the skin only. [upmc.com]

Abstract Scleroderma is a broad term encompassing both localized and systemic sclerosis. [ncbi.nlm.nih.gov]

Four patients with systemic scleroderma and 1 patient with localized scleroderma were treated with ciclosporin (CS), given in daily doses between 2.2 and 5.6 mg/kg body weight [ncbi.nlm.nih.gov]

Localized Scleroderma

It leads to sclerotic alterations of the skin, hence also called localized scleroderma. [symptoma.com]

Abstract Purpose of review Localized scleroderma, also known as morphoea, has a variety of clinical manifestations that can include systemic involvement. [doi.org]

The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993. J Rheumatol 24(1):73-80 (1997 Jan). Falanga V. Localized scleroderma. [skintherapyletter.com]

Lichen Sclerosus

Etiology of lichen sclerosus (LiS) and localized scleroderma (LoS) is uncertain and probably multifactorial. [ncbi.nlm.nih.gov]

[…] morphea (disorder) Localized scleroderma Morphea Sclerodactyly Scleroderma, linear Scleroderma, localized Clinical Information A chronic disorder, possibly autoimmune, marked [icd9data.com]

An individual can have a combination of localized scleroderma types Applies To Addison's keloid Dermatosclerosis, localized Lichen sclerosus et atrophicus Morphea Scleroderma [icd9data.com]

Basal Cell Carcinoma

Differential diagnosis of morpheaform BCC includes scar, localized superficial scleroderma (morphea), sebaceous hyperplasia, dermatofibrosarcoma protuberans, and microcystic [clevelandclinicmeded.com]

Actinic Keratosis

Actinic keratosis Other names Solar keratosis, senile keratosis (SK) Actinic keratosis seen on the back of the hands Specialty Dermatology Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis,[1][2] is a pre-cancerous[3] area of thick, scaly, or crusty skin.[4][5] The term actinic keratosis[…] [en.wikipedia.org]

Squamous Cell Carcinoma of the Skin

Invasive pigmented squamous cell carcinoma (PSCC) of the skin is reportedly rare. Herein, we evaluate an additional five cases and compare their relative frequency with non-pigmented squamous cell carcinoma (SCC). Of 46,791 archived cases of SCC, a total of five cases of PSCC were discovered for a relative[…] [ncbi.nlm.nih.gov]

Malignant Melanoma of the Skin

A mechanism that leads to resistance to certain targeted therapy drugs for melanoma has been discovered by researchers at the Moffitt Cancer Center in Tampa, Fla. The study was published in the online December issue of Cancer Discovery. While targeted biological therapy can improve survival for many melanoma[…] [web.archive.org]

Diffuse Cutaneous Systemic Scleroderma

Localized Scleroderma Localized types of scleroderma affect the skin and related tissues, and sometimes the muscle below. Internal organs are not affected. [verywell.com]

Generally, localized scleroderma is relatively mild. [scleroderma.org]

Treatment of Localized Scleroderma There is no one treatment for localized scleroderma. [center4research.org]

Sclerodactyly

There are two main varieties of scleroderma: systemic and localized. [wisegeek.com]

Eosinophilic fasciitis shows changes similar to those of localized scleroderma. [ncbi.nlm.nih.gov]

Systemic scleroderma is more likely to cause hardening of internal organs and connective tissues, while localized scleroderma tends to occur on the skin only and result in [wisegeek.com]

Keloid

Dermal fibrosis is characterized by collagen accumulation and hyperproliferation of fibroblasts. NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLRs) family, has recently been implicated in the development of hepatic fibrosis. However, the role of NLRC5 in dermal fibrosis remains[…] [ncbi.nlm.nih.gov]

Acromegaly - Cutis verticis gyrata - Corneal Leukoma Syndrome

[32] Thus, a common pathogenetic pathway for hypertrophic osteoarthropathy possibly involves localized activation of endothelial cells by an abnormal platelet population [misc.medscape.com]

[…] marker of endothelial activation and damage because high plasma levels of vWF:Ag are also found in the vasculitides, myocardial infarction, diabetic microangiopathy, and scleroderma [misc.medscape.com]

Limited Cutaneous Systemic Scleroderma

Scleroderma can be classified into 2 broad categories, which include Localized Scleroderma and Systemic Scleroderma: Localized Scleroderma: It often affects the skin tissues [dovemed.com]

Individuals who are affected by scleroderma may have the localized form or the systemic form of the disease. [medindia.net]

The two types of scleroderma are: Localized scleroderma Systemic scleroderma (also known as systemic sclerosis). [diseases.emedtv.com]

Keratomalacia

Xerophthalmia and keratomalacia are public health problems of great magnitude which are usually associated with multiple vitamin and protein deficiencies. The authors report the case of a 27-year-old commune member who subjected herself to a bizarre protein and vitamin deficient diet for many months. This ultimately[…] [ncbi.nlm.nih.gov]

Facial Hemiatrophy

Therefore, the PFH and localized scleroderma may have had the same pathological background in this case. [ncbi.nlm.nih.gov]

A 37-year-old woman had a 3-year history of involuntary spasms of the right masseter muscle in association with localized scleroderma and facial hemiatrophy. [ncbi.nlm.nih.gov]

Laxer, LOCALIZED SCLERODERMAS, Textbook of Pediatric Rheumatology, 10.1016/B978-1-4160-6581-4.10026-3, (438-447), (2011). [doi.org]

Scleroderma

OBJECTIVES: To evaluate whether there was any relation between localized scleroderma and platelet parameters. [ncbi.nlm.nih.gov]

Localized scleroderma affects the skin only. [upmc.com]

Linear Atrophoderma of Moulin

Coexistence of lichen sclerosus and morphea:a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center. [scielo.org.mx]

Synonyms and Keywords: Localized scleroderma. [wikidoc.org]

Background : Localized scleroderma also called morphea is a skin disorder of undetermined cause. [pubfacts.com]

Neonatal Scleroderma

OBJECTIVES: Juvenile localized scleroderma (JLS) usually has its onset during later childhood. [ncbi.nlm.nih.gov]

Localized scleroderma. Curr Opin Rheumatol. 2006 Nov. 18(6):606-13. [Medline]. Zulian F. Systemic manifestations in localized scleroderma. [emedicine.medscape.com]

2017 2018 2019 Billable/Specific Code Applicable To En coup de sabre lesion localized L94.0 ICD-10-CM Diagnosis Code L94.0 Localized scleroderma [morphea] 2016 2017 2018 [icd10data.com]

Eosinophilic Fasciitis

Abstract Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. [ncbi.nlm.nih.gov]

Since serum MMP-13 levels reflect disease severity of systemic sclerosis and localized scleroderma, we evaluated the clinical significance of serum MMP-13 levels in eosinophilic [ncbi.nlm.nih.gov]

Histopathologic features are discussed, as is their relationship to other forms of localized scleroderma. [ncbi.nlm.nih.gov]

Pulmonary Scleroderma

Systemic scleroderma is classified into localized scleroderma and scleroderma diffuse types. [circ.ahajournals.org]

Localized scleroderma The more common form of the disease, localized scleroderma, affects only a person's skin, usually in just a few places. [my.clevelandclinic.org]

Approximately 4% of those with localized scleroderma (such as morphea or linear or en coup de sabre) may develop respiratory symptoms, primarily restrictive pneumopathy. [sclero.org]

Aagenaes Syndrome

Lymphedema-cholestasis syndrome (LCS, Aagenaes syndrome) is the only known form of hereditary lymphedema associated with cholestasis. A locus, LCS1, has recently been mapped to chromosome 15q in a Norwegian kindred. In a consanguine Serbian Romani family with a neonate who had a combination of lymphedema and[…] [ncbi.nlm.nih.gov]

Calcinosis Circumscripta

Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma. [mjdrdypu.org]

[…] lupus erythematosus L94 Other localized connective tissue disorders L94.0 Localized scleroderma [morphea] L94.1 Linear scleroderma L94.2 Calcinosis cutis L94.4 Gottron's [icd10data.com]

MRI findings in deep and generalized morphea (localized scleroderma). AJR Am J Roentgenol 2008;190:32-9. [ PUBMED ] 6. [mjdrdypu.org]

Acquired Partial Lipodystrophy

The authors describe a case of a 43-year-old woman affected by acquired partial lipodystrophy associated with localized scleroderma and undifferentiated connective tissue [ncbi.nlm.nih.gov]

Localized scleroderma has also been reported. [24] Although uncommon, insulin resistance increases cardiovascular risk. [emedicine.medscape.com]

Localized scleroderma has also been reported. [26] Although uncommon, insulin resistance increases cardiovascular risk. [emedicine.medscape.com]

Scleroderma with Renal Involvement

Localized scleroderma</STRONG></A> <UL> <LI><A HREF="these_body.html#th.0.6.4">7.1 Clinical features</A> </LI> <LI><A HREF="these_body.html#th.0.6.5">7.2 Localized scleroderma [unige.ch]

Sometimes scleroderma affects only one area of the skin – localized scleroderma. [edren.org]

[…] sclerosis sine scleroderma — Localized scleroderma Linear scleroderma En coup de saber Morphea Generalized Plaque Mixed connective tissue disease Features of systemic sclerosis [aafp.org]

Parana Hard-Skin Syndrome

Krafchik, BR, Localized cutaneous scleroderma, Semin Dermatol 11 ( 1992 ) 65 – 72. 22. [plasticsurgerykey.com]

[…] blood vessels, muscles, and internal organs.There are two main types: localized scleroderma, which affects only the skin; and systemic scleroderma, which affects the blood [checkrare.com]

Localized forms of scleroderma.Clin Rheumat Dis 1979;5:215241.110 Pediatric Dermatology Vol. 17 No. 2 March/April 2000 [documents.tips]

Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome

Krafchik, BR, Localized cutaneous scleroderma, Semin Dermatol 11 ( 1992 ) 65 – 72. 22. [plasticsurgerykey.com]

Winkelmann, RK, Localized cutaneous scleroderma, Semin Dermatol 4 ( 1985 ) 90 – 103. 33. [plasticsurgerykey.com]

Jablonska, S; Rodnan, GP, Localized forms of scleroderma, Clin Rheum Dis 5 ( 1979 ) 215 – 241. 23. [plasticsurgerykey.com]

Calcinosis Universalis

Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma. [mjdrdypu.org]

[…] lupus erythematosus L94 Other localized connective tissue disorders L94.0 Localized scleroderma [morphea] L94.1 Linear scleroderma L94.2 Calcinosis cutis L94.4 Gottron's [icd10data.com]

MRI findings in deep and generalized morphea (localized scleroderma). AJR Am J Roentgenol 2008;190:32-9. [ PUBMED ] 6. [mjdrdypu.org]

Guttate Scleroderma

Methotrexate and corticosteroid therapy for pediatric localized scleroderma. J Pediatr 2000; 136:91–95. [link.springer.com]

D-Penicillamine in the treatment of localized scleroderma. Arch Dermatol 1990; 126:609–612. CrossRef PubMed CAS Google Scholar Neuhofer J, Fritsch P. [link.springer.com]

Classification of morphea (localized scleroderma). Mayo Clin Proc 1995; 70:1068–1076. CrossRef PubMed CAS Google Scholar Weide B, Schittek B, Klyscz T et al. [link.springer.com]

Linear Scleroderma

There are two forms of scleroderma: localized scleroderma (primarily affects the skin, most common form found in children) and systemic sclerosis (a chronic, degenerative [chop.edu]

Management of localized scleroderma. [ncbi.nlm.nih.gov]

The two main types are systemic scleroderma and localized scleroderma. [medical-dictionary.thefreedictionary.com]

Juvenile Scleroderma

Localized scleroderma: clinical spectrum and therapeutic update. [ncbi.nlm.nih.gov]

Juvenile Scleroderma Causes Genetic factors may make a child more likely to developing localized scleroderma. [arthritis.org]

were found in localized scleroderma. [scielo.br]

Lubani-Al Saleh-Teebi Syndrome

[…] epiphyseal dysplasia Localized scleroderma Locked-in syndrome Lockwood Feingold syndrome Loeys-Dietz syndrome Loeys-Dietz syndrome type 1A Loeys-Dietz syndrome type 1B Loeys-Dietz [personalizedcause.com]

Lissencephaly syndrome type 1 Lissencephaly X-linked Lissencephaly isolated Listeria infection Littoral cell angioma of the spleen Liver cancer Liver failure acute infantile Localized [personalizedcause.com]