Localized Scleroderma: Causes & Reasons

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Possible Causes for Localized Scleroderma

Systemic Scleroderma

METHODS: Patients were placed into three clinical groups: three had diffuse systemic scleroderma, 47 had limited systemic scleroderma, and nine had localized systemic scleroderma [ncbi.nlm.nih.gov]

Localized Scleroderma Localized types of scleroderma affect the skin and related tissues, and sometimes the muscle below. Internal organs are not affected. [verywellhealth.com]

Atrophy of orbital fat is a reported complication of localized scleroderma but not of systemic scleroderma. [ncbi.nlm.nih.gov]

Localized Scleroderma

the severest form of localized scleroderma. [doi.org]

Localized scleroderma. Curr Opin Rheumatol. 2006 Nov. 18(6):606-13. [Medline]. Zulian F. Systemic manifestations in localized scleroderma. [emedicine.com]

Alexander Kreuter, Localized scleroderma, Dermatologic Therapy, 25, 2, (135-147), (2012). [doi.org]

Lichen Sclerosus

[…] morphea (disorder) Localized scleroderma Morphea Sclerodactyly Scleroderma, linear Scleroderma, localized Clinical Information A chronic disorder, possibly autoimmune, marked [icd9data.com]

Etiology of lichen sclerosus (LiS) and localized scleroderma (LoS) is uncertain and probably multifactorial. [ncbi.nlm.nih.gov]

A differential diagnosis should include, but is not limited to: localized scleroderma, cutaneous discoid lupus erythematous, atrophic lichen planus, lichen simplex chronicus [clinicaladvisor.com]

Basal Cell Carcinoma

Differential diagnosis of morpheaform BCC includes scar, localized superficial scleroderma (morphea), sebaceous hyperplasia, dermatofibrosarcoma protuberans, and microcystic [clevelandclinicmeded.com]

Acromegaly - Cutis verticis gyrata - Corneal Leukoma Syndrome

[32] Thus, a common pathogenetic pathway for hypertrophic osteoarthropathy possibly involves localized activation of endothelial cells by an abnormal platelet population [misc.medscape.com]

[…] marker of endothelial activation and damage because high plasma levels of vWF:Ag are also found in the vasculitides, myocardial infarction, diabetic microangiopathy, and scleroderma [misc.medscape.com]

Actinic Keratosis

Actinic keratosis Other names Solar keratosis, senile keratosis (SK) Actinic keratosis seen on the back of the hands Specialty Dermatology Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis,[1][2] is a pre-cancerous[3] area of thick, scaly, or crusty skin.[4][5] The term actinic keratosis[…] [en.wikipedia.org]

Squamous Cell Carcinoma of the Skin

Invasive pigmented squamous cell carcinoma (PSCC) of the skin is reportedly rare. Herein, we evaluate an additional five cases and compare their relative frequency with non-pigmented squamous cell carcinoma (SCC). Of 46,791 archived cases of SCC, a total of five cases of PSCC were discovered for a relative[…] [ncbi.nlm.nih.gov]

Malignant Melanoma of the Skin

A mechanism that leads to resistance to certain targeted therapy drugs for melanoma has been discovered by researchers at the Moffitt Cancer Center in Tampa, Fla. The study was published in the online December issue of Cancer Discovery. While targeted biological therapy can improve survival for many melanoma[…] [web.archive.org]

Diffuse Cutaneous Systemic Scleroderma

Localized Scleroderma Localized types of scleroderma affect the skin and related tissues, and sometimes the muscle below. Internal organs are not affected. [verywell.com]

Generally, localized scleroderma is relatively mild. [scleroderma.org]

Treatment of Localized Scleroderma There is no one treatment for localized scleroderma. [center4research.org]

Sclerodactyly

There are two main varieties of scleroderma: systemic and localized. [wisegeek.com]

Eosinophilic fasciitis shows changes similar to those of localized scleroderma. [ncbi.nlm.nih.gov]

Systemic scleroderma is more likely to cause hardening of internal organs and connective tissues, while localized scleroderma tends to occur on the skin only and result in [wisegeek.com]

Eosinophilic Fasciitis

Abstract Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. [ncbi.nlm.nih.gov]

Since serum MMP-13 levels reflect disease severity of systemic sclerosis and localized scleroderma, we evaluated the clinical significance of serum MMP-13 levels in eosinophilic [ncbi.nlm.nih.gov]

Histopathologic features are discussed, as is their relationship to other forms of localized scleroderma. [ncbi.nlm.nih.gov]

Keloid

Dermal fibrosis is characterized by collagen accumulation and hyperproliferation of fibroblasts. NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLRs) family, has recently been implicated in the development of hepatic fibrosis. However, the role of NLRC5 in dermal fibrosis remains[…] [ncbi.nlm.nih.gov]

Limited Cutaneous Systemic Scleroderma

Scleroderma can be classified into 2 broad categories, which include Localized Scleroderma and Systemic Scleroderma: Localized Scleroderma: It often affects the skin tissues [dovemed.com]

Individuals who are affected by scleroderma may have the localized form or the systemic form of the disease. [medindia.net]

The two types of scleroderma are: Localized scleroderma Systemic scleroderma (also known as systemic sclerosis). [diseases.emedtv.com]

Keratomalacia

Xerophthalmia and keratomalacia are public health problems of great magnitude which are usually associated with multiple vitamin and protein deficiencies. The authors report the case of a 27-year-old commune member who subjected herself to a bizarre protein and vitamin deficient diet for many months. This ultimately[…] [ncbi.nlm.nih.gov]

Pulmonary Scleroderma

Systemic scleroderma is classified into localized scleroderma and scleroderma diffuse types. [circ.ahajournals.org]

Localized scleroderma The more common form of the disease, localized scleroderma, affects only a person's skin, usually in just a few places. [my.clevelandclinic.org]

Approximately 4% of those with localized scleroderma (such as morphea or linear or en coup de sabre) may develop respiratory symptoms, primarily restrictive pneumopathy. [sclero.org]

Facial Hemiatrophy

Laxer, LOCALIZED SCLERODERMAS, Textbook of Pediatric Rheumatology, 10.1016/B978-1-4160-6581-4.10026-3, (438-447), (2011). [doi.org]

Therefore, the PFH and localized scleroderma may have had the same pathological background in this case. [ncbi.nlm.nih.gov]

Summary Localized scleroderma designates a heterogeneous group of sclerotic skin disorders. [therombergsconnection.com]

Linear Atrophoderma of Moulin

Synonyms and Keywords: Localized scleroderma. [wikidoc.org]

Background : Localized scleroderma also called morphea is a skin disorder of undetermined cause. [pubfacts.com]

Localized scleroderma. Curr Opin Rheumatol. 2006 Nov. 18(6):606-13. [Medline]. Zulian F. Systemic manifestations in localized scleroderma. [emedicine.medscape.com]

Neonatal Scleroderma

Localized scleroderma. Curr Opin Rheumatol. 2006 Nov. 18(6):606-13. [Medline]. Zulian F. Systemic manifestations in localized scleroderma. [emedicine.medscape.com]

2017 2018 2019 Billable/Specific Code Applicable To En coup de sabre lesion localized L94.0 ICD-10-CM Diagnosis Code L94.0 Localized scleroderma [morphea] 2016 2017 2018 [icd10data.com]

OBJECTIVES: Juvenile localized scleroderma (JLS) usually has its onset during later childhood. [ncbi.nlm.nih.gov]

Scleroderma

OBJECTIVES: To evaluate whether there was any relation between localized scleroderma and platelet parameters. [ncbi.nlm.nih.gov]

Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case. [ncbi.nlm.nih.gov]

Calcinosis Circumscripta

Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma. [mjdrdypu.org]

[…] lupus erythematosus L94 Other localized connective tissue disorders L94.0 Localized scleroderma [morphea] L94.1 Linear scleroderma L94.2 Calcinosis cutis L94.4 Gottron's [icd10data.com]

MRI findings in deep and generalized morphea (localized scleroderma). AJR Am J Roentgenol 2008;190:32-9. [ PUBMED ] 6. [mjdrdypu.org]

Acquired Partial Lipodystrophy

The authors describe a case of a 43-year-old woman affected by acquired partial lipodystrophy associated with localized scleroderma and undifferentiated connective tissue [ncbi.nlm.nih.gov]

Localized scleroderma has also been reported. [24] Although uncommon, insulin resistance increases cardiovascular risk. [emedicine.medscape.com]

Localized scleroderma has also been reported. [26] Although uncommon, insulin resistance increases cardiovascular risk. [emedicine.medscape.com]

Aagenaes Syndrome

Lymphedema-cholestasis syndrome (LCS, Aagenaes syndrome) is the only known form of hereditary lymphedema associated with cholestasis. A locus, LCS1, has recently been mapped to chromosome 15q in a Norwegian kindred. In a consanguine Serbian Romani family with a neonate who had a combination of lymphedema and[…] [ncbi.nlm.nih.gov]

Scleroderma with Renal Involvement

Localized scleroderma</STRONG></A> <UL> <LI><A HREF="these_body.html#th.0.6.4">7.1 Clinical features</A> </LI> <LI><A HREF="these_body.html#th.0.6.5">7.2 Localized scleroderma [unige.ch]

Sometimes scleroderma affects only one area of the skin – localized scleroderma. [edren.org]

[…] sclerosis sine scleroderma — Localized scleroderma Linear scleroderma En coup de saber Morphea Generalized Plaque Mixed connective tissue disease Features of systemic sclerosis [aafp.org]

Parana Hard-Skin Syndrome

Krafchik, BR, Localized cutaneous scleroderma, Semin Dermatol 11 ( 1992 ) 65 – 72. 22. [plasticsurgerykey.com]

[…] blood vessels, muscles, and internal organs.There are two main types: localized scleroderma, which affects only the skin; and systemic scleroderma, which affects the blood [checkrare.com]

Localized forms of scleroderma.Clin Rheumat Dis 1979;5:215241.110 Pediatric Dermatology Vol. 17 No. 2 March/April 2000 [documents.tips]

Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome

Krafchik, BR, Localized cutaneous scleroderma, Semin Dermatol 11 ( 1992 ) 65 – 72. 22. [plasticsurgerykey.com]

Winkelmann, RK, Localized cutaneous scleroderma, Semin Dermatol 4 ( 1985 ) 90 – 103. 33. [plasticsurgerykey.com]

Jablonska, S; Rodnan, GP, Localized forms of scleroderma, Clin Rheum Dis 5 ( 1979 ) 215 – 241. 23. [plasticsurgerykey.com]

Calcinosis Universalis

Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma. [mjdrdypu.org]

[…] lupus erythematosus L94 Other localized connective tissue disorders L94.0 Localized scleroderma [morphea] L94.1 Linear scleroderma L94.2 Calcinosis cutis L94.4 Gottron's [icd10data.com]

MRI findings in deep and generalized morphea (localized scleroderma). AJR Am J Roentgenol 2008;190:32-9. [ PUBMED ] 6. [mjdrdypu.org]

Calcinosis Cutis

The most common cause of Dystrophic Calcinosis is localized scleroderma (CREST). Panniculitis, inflammation of the fat layer, can also cause calcinosis. [perridermatology.com]

Generally, localized scleroderma is relatively mild. [scleroderma.org]

[…] lupus erythematosus L94 Other localized connective tissue disorders L94.0 Localized scleroderma [morphea] L94.1 Linear scleroderma L94.2 Calcinosis cutis L94.4 Gottron's [icd10data.com]

Kraurosis Vulvae

Scleroderma. [genome.jp]

Localized scleroderma with bullae. Arch Dermatol Syph 1941; 43: 361-5. Pasieczny TAH. [cirp.org]

Lichen sclerosus (genital and/or extragenital) and morphea (localized scleroderma) can occur in the same patient. [dermatologyadvisor.com]

Lipodystrophy

Scleroderma Primary Atrophic Solitary Morphea Profunda (SMP) is a distinct form of localized scleroderma, mimicking localized lipoatrophy. [sclero.org]

Associations with localized scleroderma and lichen sclerosus et atrophicus have been noted. [emedicine.com]

Our observation highlights the wide spectrum of clinical presentations of localized scleroderma. [sclero.org]

Ainhum

scleroderma [morphea] L94.1 - Linear scleroderma L94.2 - Calcinosis cutis L94.3 - Sclerodactyly L94.4 - Gottron papules L94.5 - Poikiloderma vasculare atrophicans L94.6 - [icd-code.org]

A skin biopsy was performed with evidence of dermis fibrosis without findings suggested active localized scleroderma. [austinpublishinggroup.com]

[…] lupus erythematosus L94 Other localized connective tissue disorders L94.0 Localized scleroderma [morphea] L94.1 Linear scleroderma L94.2 Calcinosis cutis L94.4 Gottron's [icd10data.com]